A5005629084- Bladder and Urothelial Cancer Treatments
- Urinary and Genital Oncology Studies
- Ferroptosis and cancer prognosis
- Hormonal and reproductive studies
- Renal cell carcinoma treatment
- Prostate Cancer Treatment and Research
- Urinary Bladder and Prostate Research
- Urological Disorders and Treatments
- Prostate Cancer Diagnosis and Treatment
- Esophageal Cancer Research and Treatment
- Cancer, Lipids, and Metabolism
- Peptidase Inhibition and Analysis
- Metabolism, Diabetes, and Cancer
- Sexual function and dysfunction studies
- Minimally Invasive Surgical Techniques
- Inflammasome and immune disorders
- Metastasis and carcinoma case studies
- Sexual Differentiation and Disorders
- Infectious Disease Case Reports and Treatments
- Pelvic floor disorders treatments
- Protein Tyrosine Phosphatases
- Urologic and reproductive health conditions
- Kidney Stones and Urolithiasis Treatments
- Ureteral procedures and complications
- Adrenal and Paraganglionic Tumors
The University of Texas at Austin
2019-2025
Kaohsiung Medical University
2016-2025
Kaohsiung Medical University Chung-Ho Memorial Hospital
2016-2025
Kaohsiung Municipal Ta-Tung Hospital
2016-2025
Kaohsiung Veterans General Hospital
2025
University of Missouri
2023
Institute of Clinical Research
2023
National Yang Ming Chiao Tung University
2023
United Hospital
2020
The University of Texas Southwestern Medical Center
2019-2020
Bavachin is a natural product isolated from Psoralea corylifolia L. that has been applied as traditional medicine in Asian countries. However, the anti-inflammatory effects of bavachin on LPS-induced inflammation and NLRP3 inflammasome activation by macrophages remain unclear.We investigated LPS-activated murine macrophage cell line J774A.1 cells peritoneal macrophages.J774A.1 were pre-treated with following LPS treatment. The concentrations NO, PGE2, IL-6 IL-12p40 culture supernatant...
Current clinical challenges of prostate cancer management are to restrict tumor growth and prohibit metastasis. AICAR (5-aminoimidazole-4-carbox-amide-1-β-d-ribofuranoside), an AMP-activated protein kinase (AMPK) agonist, has demonstrated antitumor activities for several types cancers. However, the activity on cell metastasis not been extensively studied. Herein we examine effects cells. Cell was performed by MTT assay soft agar assay; apoptosis examined Annexin V/propidium iodide (PI)...
Background Urothelial carcinoma (UC) originating from the bladder (UBUC) and upper urinary tract (UTUC) is most common type of tumor. While its pathogenesis remains obscured. Computerizing a published transcriptomic database UBUC (GSE31684), we identified Inhibin, Beta A ( INHBA ) as significant upregulated gene associated with tumor progression among those growth factor activity (GO:0008083). We therefore analyzed clinicopathological significance expression in UC. Design QuantiGene assay...
Abstract Introduction Inflammation and infection are causative factors of benign prostatic hyperplasia (BPH). Urine is not sterile, urine microbiota identified by DNA sequencing can play an important role in the development BPH influence severity lower urinary tract symptoms (LUTS). Materials methods We collected mid-stream voided samples from patients control participants stored them a freezer at − 80 °C. All enrolled were requested to provide information about their clinical...
Piplartine (or Piperlongumine) is a natural alkaloid isolated from Piper longum L., which has been proposed to exhibit various biological properties such as anti-inflammatory effects; however, the effect of piplartine on sepsis not examined. This study was performed examine activities in vitro, ex vivo and using murine J774A.1 macrophage cell line, peritoneal macrophages, bone marrow-derived macrophages an animal model. The results demonstrated that suppresses iNOS COX-2 expression, reduces...
Abstract The extracellular matrix (ECM) is a dynamic and complex microenvironment that modulates cell behavior fate. Changes in ECM composition architecture have been correlated with development, differentiation, disease progression various pathologies, including breast cancer [1]. Studies shown aligned fibers drive pro-metastatic microenvironment, promoting the transformation of mammary epithelial cells into invasive ductal carcinoma via epithelial-to-mesenchymal transition (EMT) [2]....
Renal function after radical nephroureterectomy (RNU) in patients with advanced upper tract urothelial carcinoma (UTUC) is an indicator of eligibility for postoperative chemotherapy. The present study aimed to utilize machine learning predicting renal status RNU and investigate the contribution several features this prediction. retrospective included 764 medical records non‑metastatic UTUC who received from 2008 2022. were divided into training (n=534) testing (n=230) datasets. Several...
Abstract: The prevalence of androgen deficiency in men increases with aging. Two common instruments, the Aging Male Symptoms (AMS) scale and Androgen Deficiency (ADAM) questionnaire, are often used to screen for clinical practice. aim this study is compare capability AMS ADAM questionnaire detect middle‐aged Taiwanese men. In April 2008, a free health screening was conducted by Kaohsiung Medical University Hospital. All participants completed had blood samples drawn between 8:00 am noon....
ABSTRACT Transcription factor CCAAT/enhancer‐binding protein delta (CEBPD) plays multiple roles in tumor progression. Studies have demonstrated that cisplatin (CDDP) induced CEBPD expression and had led to chemotherapeutic drug resistance. However, the underlying molecular mechanisms of CDDP‐regulated its relevant CDDP responses remain elusive. MicroRNAs (miRNAs) are small non‐coding RNAs negatively regulate gene a sequence‐specific manner. Abnormal miRNAs is associated with In current...
Urothelial carcinoma (UC) occurs in the upper urinary tract (UTUC) and bladder (UBUC). The molecular pathogenesis of UC has not been fully elucidated. Through data mining a published transcriptome UBUC (GSE31684), we identified Minichromosome Maintenance Complex Component 2 (MCM2) MCM10 as two most significantly upregulated genes progression among MCM gene family, key factors for initiation DNA replication. To validate clinical significance MCM2 MCM10, immunohistochemistry, evaluated by...
To clarify if diagnostic ureteroscopy (URS) before radical nephroureterectomy for patients with upper tract urothelial carcinoma (UTUC) will increase the risk of intravesical recurrence.From retrospective review cohort at our institution, 502 UTUC who underwent bladder cuff excision were enrolled from 1990 to 2013. Cox proportional hazards model was used analyze overall survival (OS), disease-free (DFS), metastasis-free (MFS), and recurrence-free (IVRFS). The log-rank test comparing curves....
Zerumbone is a natural product isolated from the pinecone or shampoo ginger, Zingiber zerumbet (L.) Smith, which has wide range of pharmacological activities, including anti-inflammatory effects. However, effects zerumbone on activation NLRP3 inflammasome in macrophages have not been examined. This study aimed to examine LPS-induced inflammatory responses and using murine J774A.1 cells, peritoneal macrophages, bone marrow-derived macrophages. Cells were treated with following LPS LPS/ATP...
Bladder cancer is one of the most common malignancies male genitourinary urinary system. Protodioscin a steroidal saponin with anti-cancer effects on several types cancers; however, activities protodioscin bladder have not yet been investigated. Therefore, we aimed to examine cancer. Two cell lines, non-muscle-invasive 5637 cells and muscle-invasive T24 cells, were used evaluate growth, migration, invasion epithelial-mesenchymal transition(EMT) marker expressions. Transcriptome analysis was...
This study aims to investigate the factors contributing discrepancy in between biopsy Gleason score (GS) and radical prostatectomy GS patients diagnosed with prostate cancer. 341 who underwent from 2011/04 2020/12 were identified. 102 Patients initial of six after enrolled. Preoperative clinical variables pathological also obtained assessed. The optimal cut-off points for significant continuous identified by area under receiver operating characteristic curve. Upgrading was observed 63...
Upper tract urothelial carcinoma (UTUC) presents a higher incidence rate in Taiwan compared to Western societies. The aim of this study is investigate the potential metformin improving survival outcomes for patients with UTUC Taiwan.
Eastern Cooperative Oncology Group performance status (ECOG-PS) is a widely used functional measure in oncology, yet its prognostic value upper tract urothelial carcinoma remains unclear. In this multicenter study of 2473 patients undergoing radical nephroureterectomy, ECOG-PS ≥ 2 was independently associated with worse overall survival (hazard ratio [HR] 2.53, p < 0.001), cancer-specific (HR 2.02, and disease-free 1.50, = 0.003) than those 0–1. They also had higher risk major perioperative...
While the triggers for metastatic transformation of breast cancer (BC) cells remain unknown, recent evidence suggests that intrinsic cellular metabolism could be a crucial driver migratory disposition and chemoresistance. Aiming to decipher molecular mechanisms involved in BC cell metabolic maneuvering, we study how ketomimetic (ketone body-rich, low glucose) nutrient medium can engineer glycocalyx signature cells, further maneuver their response therapy. Doxorubicin (DOX) has been used as...
Despite the excellent prognosis post thyroidectomy and radioiodine therapy, papillary thyroid cancer (PTC) patients still undergo dismal outcomes, especially when tumors de-differentiation thus progress to refractory status. Our knowledge on pathogenesis mechanisms of PTC NIS protein (responsible for iodine uptake) activity is behind satisfaction. To increase our these issues, we conducted this study. We analyzed microarray data identify genes differentially expressed between normal tumor...