A5082931639- Bladder and Urothelial Cancer Treatments
- Urinary and Genital Oncology Studies
- Urinary Bladder and Prostate Research
- Pelvic floor disorders treatments
- Prostate Cancer Diagnosis and Treatment
- Renal cell carcinoma treatment
- Urologic and reproductive health conditions
- Prostate Cancer Treatment and Research
- Urinary Tract Infections Management
- Urological Disorders and Treatments
- Minimally Invasive Surgical Techniques
- Pediatric Urology and Nephrology Studies
- Kidney Stones and Urolithiasis Treatments
- Ferroptosis and cancer prognosis
- Hernia repair and management
- Adrenal and Paraganglionic Tumors
- Hereditary Neurological Disorders
- Multiple and Secondary Primary Cancers
- Epigenetics and DNA Methylation
- Infectious Disease Case Reports and Treatments
- Metabolism, Diabetes, and Cancer
- Arsenic contamination and mitigation
- Genetic factors in colorectal cancer
- Metastasis and carcinoma case studies
- Colorectal Cancer Screening and Detection
Kaohsiung Medical University
2015-2025
Kaohsiung Medical University Chung-Ho Memorial Hospital
2015-2025
Kaohsiung Municipal Ta-Tung Hospital
2015-2024
Chinese University of Hong Kong
2023
University Hospitals of Derby and Burton NHS Foundation Trust
2023
Institute of Clinical Research
2023
Bridge University
2023
United Hospital
2020
Taipei Veterans General Hospital
2001-2019
Whitehead Institute for Biomedical Research
2015
Background Urothelial carcinoma (UC) originating from the bladder (UBUC) and upper urinary tract (UTUC) is most common type of tumor. While its pathogenesis remains obscured. Computerizing a published transcriptomic database UBUC (GSE31684), we identified Inhibin, Beta A ( INHBA ) as significant upregulated gene associated with tumor progression among those growth factor activity (GO:0008083). We therefore analyzed clinicopathological significance expression in UC. Design QuantiGene assay...
Numerous microorganisms residing in the gastrointestinal and genitourinary tracts affect host health. We investigated stool voided urine samples collected from patients with benign prostatic hyperplasia (BPH) or prostate cancer (PC) a control group to explore potential relationship between human microbiota disease, aimed identify correlations pathogenic taxonomic units. studied microbial composition using 16S rRNA sequencing operational units (OTUs). Extracted genome was amplified filtered...
Upper tract urothelial carcinoma (UTUC) presents a higher incidence rate in Taiwan compared to Western societies. The aim of this study is investigate the potential metformin improving survival outcomes for patients with UTUC Taiwan.
Renal function after radical nephroureterectomy (RNU) in patients with advanced upper tract urothelial carcinoma (UTUC) is an indicator of eligibility for postoperative chemotherapy. The present study aimed to utilize machine learning predicting renal status RNU and investigate the contribution several features this prediction. retrospective included 764 medical records non‑metastatic UTUC who received from 2008 2022. were divided into training (n=534) testing (n=230) datasets. Several...
Purpose: Existing T3 subclassifications for upper tract urothelial cancer (UTUC) are limited by heterogeneity and a primary focus on renal pelvis tumors. Our study aimed to propose novel pT3 subclassification system specifically tailored UTUC patients. Materials Methods: This analyzed 120 cases from Taiwanese multicenter registry, using standardized pathology report single pathologist evaluation. Results: Univariate analysis revealed survival differences based existing subclassifications....
This study aims to investigate the factors contributing discrepancy in between biopsy Gleason score (GS) and radical prostatectomy GS patients diagnosed with prostate cancer. 341 who underwent from 2011/04 2020/12 were identified. 102 Patients initial of six after enrolled. Preoperative clinical variables pathological also obtained assessed. The optimal cut-off points for significant continuous identified by area under receiver operating characteristic curve. Upgrading was observed 63...
The importance of blood cell markers in patients with malignant tumors has been studied, but there are few studies on the prognostic value hemoglobin-to-red distribution width ratio (HRR) cancer. This is first study to investigate effect preoperative HRR upper tract urothelial carcinoma (UTUC). Our retrospective cohort included 730 UTUC who underwent nephroureterectomy from 2000 2019. Clinicopathological parameters were compared according levels, and relationship between (HRR, white [WBC]...
Abstract Background 5α-reductase inhibitors (5-ARIs) inhibit the pathway of converting testosterone to dihydrotestosterone and are widely used in benign prostatic hyperplasia patients. Since androgen receptor activation may play a role urothelial tumorigenesis, we conducted this retrospective cohort study determine whether administration is associated with bladder cancer mortality, recurrence upper tract carcinoma using Taiwan National Health Insurance database. Methods The data were sourced...
Background: Spinocerebellar ataxia type 6 (SCA6) is a neurodegenerative disorder characterized by slowly progressive and dysarthria.The mutational basis an expanded CAG repeat sequence within the coding regions of CACNL1A4 gene.Basic clinical, neuroimaging, pathological, epidemiological features have been described in literature.However, metabolic SCA6 not elucidated.Objective: To investigate SCA6.Patients Methods: Seven patients with 7 healthy individuals underwent positron emission...
Background and objectives: Bladder urothelial carcinoma is the most common type of genitourinary cancer. Patients with bladder cancer may have limited treatment efficacy related to drug toxicity, resistance or adverse effects, novel therapeutic strategies enhance increase sensitivity drugs are high clinical importance. Epigallocatechin gallate (EGCG) a polyphenolic compound found in green tea leaves, potential anti-cancer agent various types through modulating regulating multiple signaling...
Herein, we aimed to explore whether male patients with congenital collagen diseases had a higher risk of inguinal herniation than without these diseases. Data were retrospectively collected from the National Health Insurance Research Database Taiwan. The study cohort included 1,801 diagnosed based on ICD-9 CM diagnostic codes; after propensity score matching, control group comprised 6,493 men primary endpoint was hernia repair during observation period. During median follow-up period 133.9...
Mass spectrometry (MS)-based single-cell proteomics (SCP) provides us the opportunity to unbiasedly explore biological variability within cells without limitation of antibody availability. This field is rapidly developed with main focuses on instrument advancement, sample preparation refinement, and signal boosting methods; however, optimal data processing analysis are rarely investigated which holds an arduous challenge because high proportion missing values batch effect. Here, we...
The prognostic value of central pathology review in upper urinary tract cancer (UTUC) remains inadequately addressed existing literature. In this study, we conducted an extensive and presented its influence on multi-center UTUC studies. We a retrospective patients who underwent radical nephroureterectomy or segmental resection for to determine eligibility review. the Taiwan Collaboration cohort, 377 cases met criteria assessed agreement between pathologists using both total percentage simple...
This study aimed to compare the oncological outcomes and surgical complications of patients with upper tract urothelial carcinoma (UTUC) treated different minimally invasive techniques for nephroureterectomy.From updated data Taiwan UTUC Collaboration Group, a total 3,333 were identified. After excluding ineligible cases, we retrospectively included 1,340 from 15 institutions who received hand-assisted laparoscopic nephroureterectomy (HALNU), (LNU) or robotic (RNU) between 2001 2021....
We sought to examine the effect of tumor location on prognosis patients with upper tract urothelial carcinoma (UTUC) treated radical nephroureterectomy (RNU). This retrospective study came from Taiwan UTUC Collaboration Group, which consisted 2658 at 15 institutions in 1988 2019. Patients kidney-sparing management, both renal pelvic and ureteral tumors, as well lacking complete data were excluded; remaining 1436 divided into two groups: (RPT) (UT), 842 594 patients, respectively. RPT was...