A5102999086- Bladder and Urothelial Cancer Treatments
- Ferroptosis and cancer prognosis
- Prostate Cancer Treatment and Research
- Glutathione Transferases and Polymorphisms
- Urinary and Genital Oncology Studies
- Kidney Stones and Urolithiasis Treatments
- Lung Cancer Treatments and Mutations
- Exercise and Physiological Responses
- Paleopathology and ancient diseases
- Thermoregulation and physiological responses
- Hormonal and reproductive studies
- Wnt/β-catenin signaling in development and cancer
- Urological Disorders and Treatments
- Metabolism, Diabetes, and Cancer
- Epigenetics and DNA Methylation
- Cancer, Lipids, and Metabolism
- Testicular diseases and treatments
- Thyroid Cancer Diagnosis and Treatment
- Cancer survivorship and care
- Brain Metastases and Treatment
- Acute Kidney Injury Research
- Infrared Thermography in Medicine
- Synthetic Organic Chemistry Methods
- Lanthanide and Transition Metal Complexes
- Cancer-related gene regulation
Chi Mei Medical Center
2015-2024
Kaohsiung Municipal Kai-Syuan Psychiatric Hospital
2023
National Cheng Kung University
2016-2023
Tamkang University
2016
National Taiwan University
2015
National Tsing Hua University
2007
Current clinical challenges of prostate cancer management are to restrict tumor growth and prohibit metastasis. AICAR (5-aminoimidazole-4-carbox-amide-1-β-d-ribofuranoside), an AMP-activated protein kinase (AMPK) agonist, has demonstrated antitumor activities for several types cancers. However, the activity on cell metastasis not been extensively studied. Herein we examine effects cells. Cell was performed by MTT assay soft agar assay; apoptosis examined Annexin V/propidium iodide (PI)...
Testicular hyperthermia has been noted in men who work high ambient temperatures. Scrotal temperatures above the normal range caused germ cell loss testes and resulted male subfertility. In adult rats, exercising at a higher environmental temperature (36 °C with relative humidity of 50%, 52 min) exertional heat stroke (EHS) characterized by scrotal hyperthermia, impaired sperm quality, dysmorphology testes, prostates bladders, erectile dysfunction. Here, we aim to ascertain whether...
Background and Purpose: This research aimed to excavate the alternative mechanism of CEBPD on tumor growth explore biological significance CEBPD/hsa-miR-429/VEGFA axis angiogenesis in urothelial carcinoma (UC). Methods: Quantitative RT-PCR, immunoblotting assay tube formation examined effect hsa-miR-429 mimic or/and inhibitor VEGFA expression CEBPD-overexpressing UC-derived cells. The association between CEBPD, hsa-miR-429, microvascular density (MVD) clinical outcome were evaluated 296...
Abstract The association of exertional heat stroke (EHS) and testicular morphological changes affecting sperm quality, as well the EHS hypothalamic sexual behavior, has yet to be elucidated. This study aimed elucidate effects on fertility, erectile function, morphology in male rats. Animals were exercised at higher room temperature (36 ℃ relative humidity 50%) induce EHS, characterized by excessive hyperthermia, neurobehavioral deficits, cell damage, systemic inflammation, coagulopathy,...
Nephrotoxic Polypharmacy and Risk of Contrast Medium–Induced Nephropathy in Hospitalized Patients Undergoing Contrast-Enhanced CTYunn-Fang Ho1,2,3, Kun-Lin Hsieh1, Fan-Lu Kung2, Fe-Lin Lin Wu1,2, Ling-Ling Hsieh2,3, Hua Chou3 Shyh-Jye Chen4,5Audio Available | Share
Abstract Background Staghorn stones require surgical treatment to prevent serious complications. Multitract percutaneous nephrolithotomy (PNL) causes great renal parenchymal injury and blood loss. One-stage endoscopic combined intrarenal surgery (ECIRS) entails the use of antegrade nephroscope retrograde flexible ureteroscope clear staghorn stone, which may overcome limitations multitract PNL. We aimed compare perioperative outcomes mini ECIRS minimally invasive PNL in stone management....
Cartilage oligomeric matrix protein (COMP) is known as a large pentameric glycoprotein, which interacts with various extracellular proteins in tissues. COMP has been reported to play role multiple connective tissue disorders. Recently, elevated levels have found be associated increased tumor size, metastases, faster recurrence of cancer, and overall poorer survival several cancers. However, the clinical importance urothelial carcinoma remains unclear. We investigated association between...
A mid-aged male presented with progressive lower urinary tract symptoms (LUTS) for years. Huge prostate low serum prostate-specific antigen (PSA) level was detected. The specimen from transurethral resection revealed surprising pathology finding as malignant peripheral nerve sheath tumor (MPNST). Considering its huge size (more than 300 gm) and location, we prescribed neoadjuvant chemotherapy firstly. became regressive then radical surgical achieved. Adjuvant multimodality treatment...
No AccessJournal of UrologyAdult Urology1 Apr 2022Comparison Surgical or Medical Castration-Related Cardiotoxicity in Patients with Prostate CancerThis article is commented on by the following:Editorial CommentEditorial Comment Wei-Chih Kan, Kun-Lin Hsieh, Yi-Chen Chen, Chung Han Ho, Chon-Seng Hong, Chun-Yen Chiang, Nan-Chun Wu, Michael Jhih-Yuan Shih, Zhih-Cherng and Wei-Ting Chang KanWei-Chih Kan Division Nephrology, Department Internal Medicine, Chi Mei Center, Tainan, Taiwan Biological...
Interstitial cystitis/bladder pain syndrome (IC/BPS) is not only a chronic urinary bladder but also associated with multifactorial etiology. Our study aimed to test the hypothesis that IC/BPS subsequent increased risks of outpatient visits and hospitalizations. Using nationwide database, diagnoses were based on International Classification Codes (ICD-9-CM) (595.1) at least three services during 2002-2008, (n = 27,990) cystoscopic finding Hunner type and/or glomerulation pre-audit criteria....
In recent years, superconducting RF cavities have been increasingly adopted for use in modern accelerator and light-source facilities. The microwave power is coupled into the accelerating cavity typically through a waveguide or coaxial coupler. multipactor discharge coupler constitutes one of most serious problems to reliable operation cavities. Due lack multipacting-free structures, processing becomes required routine procedure ensure system. However, with negligible wall losses, variations...
Although androgen deprivation therapy (ADT) has been proposed to be associated with a higher risk of venous thromboembolisms (VTEs), whether gonadotropin-releasing hormones (GnRHs), such as both agonists and antagonists, are also VTEs remain unclear. Using the Taiwan Cancer Registry (TCR) linked National Health Insurance Research Database, we identified patients diagnosed prostate cancer from 2008 2015. Patients who received GnRH were 1:1 propensity score matched non-GnRH users by age stage...
Abstract Background With the advance in genome-wide analyses, genetic alternations have been found to play an important role carcinogenesis and aggressiveness of UC. Through bioinformatic analysis gene expression profiles urinary bladder urothelial carcinoma (UBUC) from publicly available GEO dataset (GSE31684), Zinc finger SCAN domain containing 4 (ZSCAN4) was identified as a significant downregulated muscle-invasive cancer when compared with non-muscle-invasive cancer. Methods The ZSCAN4...
Abstract Background Dihydropyrimidinase-like 3 (DPYSL3) is a cytosolic phosphoprotein expressed in the nervous system and crucial for neurogenesis. A previous study showed that increased DPYSL3 expression promotes tumour aggressiveness pancreatic ductal adenocarcinoma, gastric cancer, colon cancer. However, role of affecting biological behaviour urothelial carcinoma (UC) not yet understood. Methods UC transcriptomic dataset from Gene Expression Omnibus Urothelial Bladder Cancer (BLCA) The...
<b><i>Introduction:</i></b> Dysregulation of metal ion homeostasis is associated with urothelial carcinogenesis. From a published urinary bladder carcinoma (UBUC) transcriptome, we identified metallothionein 2A (MT2A) as the most significantly upregulated gene implicated in cancer progression among binding-related genes. Therefore, analyzed association between MT2A expression and clinical significance our well-characterized cohort patients upper tract (UTUC) UBUC....
Photonic microwave time delays using semiconductor lasers at period-one nonlinear dynamics is experimentally investigated. A wide tunable range of the delay, about 114 ps, over a broad frequency 4 GHz realized by simply adjusting power an optical input.
Purpose: Radical cystectomy (RC) has long been the standard of care for management muscle-invasive bladder cancer (MIBC). However, an increasing trend bladder-sparing trimodal therapy (TMT) using maximal transurethral resection tumor, followed by radiation (RT) with concomitant radiosensitizing chemotherapy, advocated. We compared differences regarding long-term oncological outcomes between patients who accepted RC or TMT MIBC. Materials and Methods: Between January 2012 December 2018, 207...