A5039476669- Inflammasome and immune disorders
- Prostate Cancer Treatment and Research
- Immune Response and Inflammation
- Cancer-related molecular mechanisms research
- Neuroinflammation and Neurodegeneration Mechanisms
- MicroRNA in disease regulation
- Extracellular vesicles in disease
- Immune cells in cancer
- Bioinformatics and Genomic Networks
- Cancer, Hypoxia, and Metabolism
- Cancer, Lipids, and Metabolism
- Bladder and Urothelial Cancer Treatments
- Ferroptosis and cancer prognosis
- Hepatitis C virus research
- Autophagy in Disease and Therapy
- Circular RNAs in diseases
- Molecular Biology Techniques and Applications
- Ubiquitin and proteasome pathways
- Bioactive Compounds and Antitumor Agents
- Gene expression and cancer classification
- Liver Disease Diagnosis and Treatment
- Urinary and Genital Oncology Studies
- Retinal Diseases and Treatments
- Tea Polyphenols and Effects
- Exercise and Physiological Responses
Kaohsiung Medical University
2016-2025
Kaohsiung Medical University Chung-Ho Memorial Hospital
2017-2024
National Pingtung University of Science and Technology
2022-2024
National Institute of Infectious Diseases
2016
National Health Research Institutes
2011-2012
National Tsing Hua University
2009-2012
The University of Texas Southwestern Medical Center
2012
China Medical University Hospital
2010
China Medical University
2006-2010
National Taiwan Sport University
2010
Abstract An integrative multi-omics database is needed urgently, because focusing only on analysis of one-dimensional data falls far short providing an understanding cancer. Previously, we presented DriverDB, a cancer driver gene that applies published bioinformatics algorithms to identify genes/mutations. The updated DriverDBv3 (http://ngs.ym.edu.tw/driverdb) designed interpret omics’ sophisticated information with concise visualization. To offer diverse insights into molecular...
Hepatocellular carcinoma (HCC) is a leading cause of death, resulting in over 700 thousand deaths annually worldwide. Chemotherapy the primary therapeutic strategy for patients with late‐stage HCC. Heteronemin marine natural product isolated from Hippospongia sp. that has been found to protect against carcinogenesis cholangiocarcinoma, prostate cancer, and acute myeloid leukemia. In this study, heteronemin was inhibit proliferation HCC cell lines HA22T HA59T induce apoptosis via caspase...
Abstract Corylin is a main compound isolated from Psoralea corylifolia L. (Fabaceae). A variety of pharmacological effects such as antioxidant, anti-proliferation, and anti-inflammatory properties corylin have been reported. Nevertheless, the effect in microbial infection sepsis remains unclear. In present study, we investigated corylin. Our experimental results demonstrated that inhibited production TNF-α, IL-6 NO by both LPS-activated RAW 264.7 cells murine peritoneal macrophages....
We previously presented DriverDB, a database that incorporates ∼6000 cases of exome-seq data, in addition to annotation databases and published bioinformatics algorithms dedicated driver gene/mutation identification. The provides two points view, 'Cancer' 'Gene', help researchers visualize the relationships between cancers genes/mutations. In updated DriverDBv2 (http://ngs.ym.edu.tw/driverdb) herein, we incorporated >9500 cancer-related RNA-seq datasets >7000 more from Cancer Genome Atlas...
Bavachin is a natural product isolated from Psoralea corylifolia L. that has been applied as traditional medicine in Asian countries. However, the anti-inflammatory effects of bavachin on LPS-induced inflammation and NLRP3 inflammasome activation by macrophages remain unclear.We investigated LPS-activated murine macrophage cell line J774A.1 cells peritoneal macrophages.J774A.1 were pre-treated with following LPS treatment. The concentrations NO, PGE2, IL-6 IL-12p40 culture supernatant...
Current clinical challenges of prostate cancer management are to restrict tumor growth and prohibit metastasis. AICAR (5-aminoimidazole-4-carbox-amide-1-β-d-ribofuranoside), an AMP-activated protein kinase (AMPK) agonist, has demonstrated antitumor activities for several types cancers. However, the activity on cell metastasis not been extensively studied. Herein we examine effects cells. Cell was performed by MTT assay soft agar assay; apoptosis examined Annexin V/propidium iodide (PI)...
Background and Purpose Mitochondrial dysfunction plays a role in the progression of cardiovascular diseases including heart failure. 3‐Hydroxy‐3‐methylglutaryl‐CoA reductase inhibitors (statins), which inhibit ROS synthesis, show cardioprotective effects chronic However, beneficial statins mitochondrial protection failure remains unclear. Experimental Approach Rats were treated with angiotensin II (1.5 mg·kg −1 ·day ) or co‐administered simvastatin (oral, 10 for 14 days; then administration...
Inflammation has been found to be associated with many neurodegenerative diseases, including Parkinson's and dementia. Attenuation of microglia-induced inflammation is a strategy that impedes the progression diseases.We used lipopolysaccharide (LPS) simulate murine microglia cells (BV2 cells) as an experimental model mimic inflammatory environment in brain. In addition, we examined anti-inflammatory ability corylin, main compound isolated from Psoralea corylifolia L. commonly Chinese herbal...
Exosomes are implicated in cancer cell development, migration and invasion. Pigment epithelium-derived factor (PEDF) is a secreted anticancer protein that can regulate lung progression; however, the role of PEDF non-small (NSCLC), including metastasis cell-derived exosome secretion, unclear. In this study, we analyzed effects on exosome-mediated migration, invasion, tumorigenicity cultured NSCLC cells. The results showed overexpression significantly reduced invasion while inducing...
Epigenetic regulation and mitochondrial dysfunction are essential to the progression of idiopathic pulmonary fibrosis (IPF). Curcumin (CCM) in inhibits by regulating expression specific miRNAs fibroblast function; however, underlying mechanism is unclear. C57BL/6 mice were intratracheally injected with bleomycin (5 mg/kg) treated CCM (25 mg/kg body weight/3 times per week, intraperitoneal injection) for 28 days. Verhoeff–Van Gieson, Picro sirius red, Masson's trichrome staining used examine...
We previously presented the YM500 database, which contains >8000 small RNA sequencing (smRNA-seq) data sets and integrated analysis results for various cancer miRNome studies. In updated YM500v3 database (http://ngs.ym.edu.tw/ym500/) herein, we not only focus on miRNAs but also other functional non-coding RNAs (sncRNAs), such as PIWI-interacting (piRNAs), tRNA-derived fragments (tRFs), nuclear (snRNAs) nucleolar (snoRNAs). There is growing knowledge of role sncRNAs in gene regulation...
Exosome-mediated communication within the cardiac microenvironment is associated with fibrosis. Simvastatin (SIM), a potent statin, protects against fibrosis, but its mechanism of action unclear. We investigated inhibitory effects and underlying simvastatin in by regulating exosome-mediated communication. Male Sprague-Dawley rats were treated angiotensin (Ang) II alone, or SIM for 28 d. Cardiac expressions fibrosis-associated proteins mRNAs, collagen fiber arrangement deposition examined....
Purpose: Neurodegenerative diseases are associated with neuroinflammation along activation of microglia and oxidative stress, but currently lack effective treatments. Punicalagin is a natural bio-sourced product that exhibits anti-inflammatory effects on several chronic diseases; however, the anti-oxidative have not been well examined. This study aimed to investigate punicalagin LPS-induced inflammatory responses, NLRP3 inflammasome activation, production ROS using murine BV2 cells. Methods:...
Abstract Background Long-term consumption of an excessive fat and sucrose diet (Western diet, WD) has been considered a risk factor for metabolic syndrome (MS) cardiovascular disease. Caveolae caveolin-1 (CAV-1) proteins are involved in lipid transport metabolism. However, studies investigating CAV-1 expression, cardiac remodeling, dysfunction caused by MS, limited. This study aimed to investigate the correlation between expression abnormal accumulation endothelium myocardium WD-induced...
Caffeic acid phenethyl ester (CAPE) is the main bioactive component of poplar type propolis. We previously reported that treatment with caffeic suppressed cell proliferation, tumor growth, as well migration and invasion prostate cancer (PCa) cells via inhibition signaling pathways AKT, c-Myc, Wnt EGFR. also demonstrated combined CAPE docetaxel altered genes involved in glycolysis tricarboxylic (TCA) cycle. therefore suspect may interfere glucose metabolism PCa cells. Seahorse Bioenergetics...
Di(2-ethylhexyl) phthalate (DEHP) is a commonly used plasticizer, and human exposure to phthalates major health concern. DEHP, which widely recognized as an endocrine disruptor, associated with increased risk of several diseases, including breast cancer. Triple-negative cancer (TNBC) aggressive subtype cancer, metastasis the leading cause TNBC-related mortality. However, correlation between DEHP TNBC remains elusive. In present study, we found that prolonged treatment enhanced migration...
Aloe, a polyphenolic anthranoid-containing Aloe vera leaves, is Chinese medicine and popular dietary supplement worldwide. In in vivo situations, anthranoids are extensively broken down into glucuronides sulfate metabolites by the gut liver. The anti-inflammatory potential of aloe has not been examined. aim this study was to investigate effects from vitro (lipopolysaccharides (LPS)-activated RAW264.7 macrophages) ex (LPS-activated peritoneal (LPS-induced septic mice). production...
Shikonin is a naphthoquinone isolated from the dried root of Lithospermum erythrorhizon, an herb used in Chinese medicine. Although several studies have indicated that shikonin exhibits antitumor activity breast cancer, mechanism action remains unclear. In present study, we performed transcriptome analysis using RNA-seq and explored regulating growth different types cancer cells. The IC50 on MCF-7, SKBR-3 MDA-MB-231 cells were 10.3 μΜ, 15.0 μΜ respectively. Our results also demonstrated...
Piplartine (or Piperlongumine) is a natural alkaloid isolated from Piper longum L., which has been proposed to exhibit various biological properties such as anti-inflammatory effects; however, the effect of piplartine on sepsis not examined. This study was performed examine activities in vitro, ex vivo and using murine J774A.1 macrophage cell line, peritoneal macrophages, bone marrow-derived macrophages an animal model. The results demonstrated that suppresses iNOS COX-2 expression, reduces...