A5101844605- Neuroscience and Neuropharmacology Research
- Pancreatic function and diabetes
- Ion channel regulation and function
- Receptor Mechanisms and Signaling
- Regulation of Appetite and Obesity
- Diet and metabolism studies
- Cardiac Ischemia and Reperfusion
- Adipose Tissue and Metabolism
- Neurotransmitter Receptor Influence on Behavior
- Tryptophan and brain disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurogenesis and neuroplasticity mechanisms
- Diverse Aspects of Tourism Research
- Genomics, phytochemicals, and oxidative stress
- Stress Responses and Cortisol
- Parkinson's Disease Mechanisms and Treatments
- Metabolism and Genetic Disorders
- Adenosine and Purinergic Signaling
- Neuroscience and Neural Engineering
- Neuropeptides and Animal Physiology
- Religious Tourism and Spaces
- Pharmacological Effects and Toxicity Studies
- Epigenetics and DNA Methylation
- Nuclear Receptors and Signaling
- Recreation, Leisure, Wilderness Management
National Health Research Institutes
2025
National Cheng Kung University
2013-2024
China Medical University
2012-2024
Mackay Memorial Hospital
2015-2023
Chang Gung University
2003-2020
Providence University
2020
Tainan University of Technology
2018
Oregon Health & Science University
2010-2014
Oregon Medical Research Center
2014
National Taiwan University
2012-2013
Oxidative stress has been implicated in the etiology of Parkinson's disease (PD) and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) animal model PD. It is known that under conditions oxidative stress, transcription factor NF-E2-related (Nrf2) binds to antioxidant response element (ARE) induce phase II detoxification enzymes. To investigate role Nrf2 process MPTP-induced toxicity, mice expressing human placental alkaline phosphatase (hPAP) gene driven by a promoter containing core ARE...
Abstract This study investigates the interrelationships between community attachment, economic dependence on tourism, perceived positive tourism impacts, negative impacts and support for development. A total of 239 respondents completed a survey conducted at Tainan city, heritage city in southern Taiwan. The data were analysed using structural equation modelling (SEM) technique; results reveal that both attachment have significant effects impact and, turn, can affect Although development,...
Astrocytes support neuronal antioxidant capacity by releasing glutathione, which is cleaved to cysteine in brain extracellular space. Free then taken up neurons through excitatory amino acid transporter 3 [EAAT3; also termed Slc1a1 (solute carrier family 1 member 1)] de novo glutathione synthesis. Activation of the nuclear factor erythroid 2-related 2 (Nrf2)-antioxidant responsive element (ARE) pathway oxidative stress promotes astrocyte release but it remains unknown how this coupled Here...
Mitochondrial dysfunction and oxidative stress are involved in the pathogenesis of Parkinson's disease (PD). morphology is dynamic precisely regulated by mitochondrial fission fusion machinery. Aberrant fragmentation controlled protein, dynamin-related protein 1 (Drp1), may result cell death. Our previous results showed that melatonin protected neurons inhibiting a 1-methyl-4-phenylpyridinium (MPP(+) )-induced PD model. However, effect on dynamics remains uncharacterized. Herein, we...
Comorbidity exists between metabolic disorders and depressive syndrome with unclear mechanisms. To characterize the causal relationship, we adopted a 12-week high-fat diet (HFD) to induce disorder phenotypes in mice. Initially, identified an enhanced glutamatergic input nucleus accumbens of HFD Retrograde tracing chemogenetic inhibition showed that hyperactive ventral hippocampal afferents determined exhibition depression-like behavior Using lentiviral knockdown overexpression approaches,...
We studied the potential mechanisms of valproic acid (VPA) in treatment glioblastoma multiforme (GBM). Using human U87, GBM8401, and DBTRG-05MG GBM-derived cell lines, VPA at concentrations 5 to 20 mM induced G2/M cycle arrest increased production reactive oxygen species (ROS). Stress-related molecules such as paraoxonase 2 (PON2), cyclin B1, cdc2, Bcl-xL were downregulated, but p27, p21 Bim upregulated by treatment. response element on PON2 promoter was localized position -400/-1. protein...
Caffeic acid phenethyl ester (CAPE) is the main bioactive component of poplar type propolis. We previously reported that treatment with caffeic suppressed cell proliferation, tumor growth, as well migration and invasion prostate cancer (PCa) cells via inhibition signaling pathways AKT, c-Myc, Wnt EGFR. also demonstrated combined CAPE docetaxel altered genes involved in glycolysis tricarboxylic (TCA) cycle. therefore suspect may interfere glucose metabolism PCa cells. Seahorse Bioenergetics...
We studied the smooth muscle cell differentiation capability of human placental multipotent mesenchymal stromal cells (hPMSCs) and identified how endothelial recruit hPMSCs participating in vessel formation. from term placentas were induced to differentiate into under induction conditions different matrix substrates. assessed umbilical veins for platelet-derived growth factor (PDGF)-BB expression induce hPMSC PDGFR-beta STAT3 activation. Endothelial co-cultured with vitro angiogenesis. Cell...
The prevalence of diabetes is rapidly increasing worldwide and highly associated with the incidence depression. Pioglitazone, a Peroxisome proliferator-activated receptor gamma (PPAR-γ) agonist, widely used for treating patients type 2 diabetes. However, whether pioglitazone alleviates metabolic disorder-related depression astrocytic deficits remains unclear. Here we showed that 12 weeks high-fat diet (HFD) feeding (from 8- to 20-week-old) induced not only obesity insulin resistance, but...
Objectives The association between viral hepatitis (B and C) oral cavity cancer has been widely debated. This nationwide, population-based cohort study assessed the subsequent risk of among patients with chronic infection. Materials Methods Data were retrieved from insurance claims data 1,000,000 randomly sampled individuals covered under Taiwan National Health Insurance system. We identified a total 21,199 adults infection (12,369 HBV alone, 5,311 HCV 3,519 HBV/HCV dual infections)...
Abstract Background Many genetic diseases are due to defects in protein trafficking where the mutant is recognized by quality control systems, retained endoplasmic reticulum (ER), and degraded proteasome. In many cases, retains function if it can be trafficked its proper cellular location. We have identified structurally diverse correctors that restore of most common mutation causing cystic fibrosis, F508del-CFTR. Most these do not act directly as ligands CFTR, but indirectly on other...
The pancreatic β-cell ATP-sensitive potassium (K ATP ) channel is a multimeric protein complex composed of four inwardly rectifying (Kir6.2) and sulfonylurea receptor 1 (SUR1) subunits. K channels play key role in glucose-stimulated insulin secretion by linking glucose metabolism to membrane excitability. Many SUR1 Kir6.2 mutations reduce function disrupting biogenesis processing, resulting disease. To better understand the mechanisms governing biogenesis, proteomics approach was used...