A5100646498- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Cytokine Signaling Pathways and Interactions
- Renal function and acid-base balance
- Renin-Angiotensin System Studies
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Growth Hormone and Insulin-like Growth Factors
- Asymmetric Synthesis and Catalysis
- Chronic Kidney Disease and Diabetes
- Asymmetric Hydrogenation and Catalysis
- Dialysis and Renal Disease Management
- Air Quality and Health Impacts
- Mesenchymal stem cell research
- Synthesis and Catalytic Reactions
- Synthesis of Tetrazole Derivatives
- Air Quality Monitoring and Forecasting
- Diabetes Treatment and Management
- Acute Kidney Injury Research
- TGF-β signaling in diseases
- Cancer-related molecular mechanisms research
- Pregnancy and preeclampsia studies
- Gout, Hyperuricemia, Uric Acid
- Calcium signaling and nucleotide metabolism
- Hormonal Regulation and Hypertension
- RNA modifications and cancer
Mackay Memorial Hospital
2014-2025
Mackay Junior College of Medicine, Nursing and Management
2014-2023
Mackay Medical College
2015-2019
National Yang Ming Chiao Tung University
2017-2019
Chang Gung University
2012-2014
Fooyin University
2011-2012
Merck & Co., Inc., Rahway, NJ, USA (United States)
1999-2009
Merck Canada Inc. (Canada)
2009
Rutgers, The State University of New Jersey
2009
Merck (Japan)
1998
A highly enantioselective and practical synthesis of the HIV-1 reverse transcriptase inhibitor efavirenz (1) is described. The proceeds in 62% overall yield seven steps from 4-chloroaniline (6) to give excellent chemical optical purity. novel, addition Li-cyclopropyl acetylide (4a) p-methoxybenzyl-protected ketoaniline 3a mediated by (1R,2S)-N-pyrrolidinylnorephedrine lithium alkoxide (5a) establishes stereogenic center target with a remarkable level stereocontrol.
Inhaled particulate matter 2.5 (PM ) can cause lung injury by inducing serious inflammation in tissue.Renin-angiotensin system (RAS) is involved the pathogenesis of inflammatory diseases and regulates response.Angiotensin-converting enzyme II (ACE2), which produced through angiotensin-converting (ACE)/angiotensin (Ang II) axis, protects against disease.However, few studies have focused on relationships between PM ACE2.Therefore, we aimed to explore role ACE2 -induced acute (ALI).An animal...
Kilogram-scale synthesis of the HIV reverse transcriptase inhibitor efavirenz was achieved by means a highly enantioselective alkynylation prochiral ketones 1 with alkynyllithium or alkynylmagnesium reagents in presence chiral zinc aminoalkoxides as mediators. With achiral auxiliary 2,2,2-trifluoroethanol (R3 =CF3 CH2 ), precursor 2 (R1 =H, R2 =cyclopropyl) obtained an ee 99.2%.
We studied the smooth muscle cell differentiation capability of human placental multipotent mesenchymal stromal cells (hPMSCs) and identified how endothelial recruit hPMSCs participating in vessel formation. from term placentas were induced to differentiate into under induction conditions different matrix substrates. assessed umbilical veins for platelet-derived growth factor (PDGF)-BB expression induce hPMSC PDGFR-beta STAT3 activation. Endothelial co-cultured with vitro angiogenesis. Cell...
The thyroid hormone, 3, 3′, 5-triiodo-L-thyronine (T3), has been shown to modulate cellular processes via interactions with hormone receptors (TRs), but the secretory proteins that are regulated exert these effects remain be characterized. Brain-specific serine protease 4 (BSSP4), a member of human family, participates in extracellular matrix remodeling. However, physiological role and underlying mechanism T3-mediated regulation BSSP4 hepatocellular carcinogenesis yet established. response...
Gastric cancer is the sixth leading cause of cancer‐related death in T aiwan, and identification related factors essential to increase patient survival. ADP ‐ribosylation factor 1 ( ARF 1) was initially identified using 2‐ D electrophoresis combined with MALDI –time‐of‐flight mass spectrometry. belongs R as superfamily or GTP ‐binding protein family has been shown enhance cell proliferation. In current study, we evaluated potential a biomarker for gastric detection. m RNA upregulated tumor...
Renal anemia is a common complication in patients with advanced chronic kidney disease. In vitro studies have shown that indoxyl sulfate decreases erythropoietin production. Whether this effect seen vivo remains unclear. Our goal was to explore the role of renal anemia. We found serum levels are significantly and negatively associated human. A multiple stepwise linear regression analyses after adjustment for other independent parameters revealed free sulfate, total were levels. animal...
Abstract In this study, we developed composite chitosan beads combining various metal ions, including Ni 2+ , Cu Zn and Fe for direct adsorption of enterovirus 71 (EV71). The metal‐ion species had significant effects on the capacity beads. Among these ion‐composite beads, ‐chitosan exhibited best EV71. Using a concentration 0.01‐M was found to provide bead formation EV71 adsorption. at neutral or alkaline pH favored. Under competitive condition with albumin proteins, in culture media....
// Cheng-Yi Chen 1, 2, 3 , Cheng-Jui Lin 4, 5 Chih-Sheng Fang-Ju Sun 6 Chi-Feng Pan 4 Han-Hsiang and Chih-Jen Wu 5, 7, 8 1 Division of Nephrology, Department Internal Medicine, Mackay Memorial Hospital, Hsinchu, Taiwan 2 MacKay Junior College Nursing Management, Taipei, Biological Science Technology, National Chiao Tung University, Taipei Medical Research, 7 Graduate Institute Sciences Pharmacology, School China University Taichung, Correspondence to: Wu, email: wcjyali@yahoo.com.tw...
The prognosis of critically ill patients with cirrhosis is poor. Our aim was to identify an objective variable that can improve the prognostic value Model End-Stage Liver Disease (MELD) score in who have and are admitted intensive care unit (ICU). This retrospective cohort study included 177 had liver were ICU. Data pertaining arterial blood gas-related parameters other variables obtained on day ICU admission. overall mortality rate 36.2%. bicarbonate (HCO3) level found be independent...
Chiral amines are common structural motifs in a large number of commercially important compounds. Catalytic hydrogenation imines represents an synthetic tool for introduction the amine moiety. Despite successful examples asymmetric hydrogenation, many systems leave quite bit room improvement enantiocontrol. The necessity using protective groups cases decreases value corresponding methods. This paper provides fundamentally approach to chiral via unprotected ketoimines, which can be easily...
Diabetic nephropathy (DN) is a crucial metabolic health problem. The renin–angiotensin system (RAS) well known to play an important role in DN. Abnormal RAS activity can cause the over-accumulation of angiotensin II (Ang II). Angiotensin-converting enzyme inhibitor (ACEI) administration has been proposed as therapy, but previous studies have also indicated that chymase, hydrolyzes I Ang ACE-independent pathway, may progression Therefore, this study established model severe DN db/db and ACE2...
<div>Abstract<p><b>Purpose:</b> The proinflammatory cytokine interleukin-32 (IL-32) is a novel tumor marker highly expressed in various human carcinomas, including gastric cancer. However, its effects on prognosis of patients with cancer and metastasis are virtually unknown at present. main aim this study was to explore the clinical significance IL-32 further elucidate molecular mechanisms underlying IL-32–mediated migration...
<p>PDF file - 1228KB, Supplementary Table SI. Primary antibody for western blot. SII. immunohistochemistry. SIII. ShRNA gene silencing. SIV. Inhibitors kinase inhibition. Supplemental Materials and Methods. Figures Legends. Figure S1. IL-32 is overexpressing in GC specimens. S2. Ectopic overexpression of promotes migration TSGH9201 cells. S3. enhances cell invasion beta-catenin activity a doxycycline-inducible expression system. S4. PI3K/AKT inhibitor (LY294002) diminishes...