A5070237889- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- MicroRNA in disease regulation
- Cancer, Hypoxia, and Metabolism
- Liver Disease Diagnosis and Treatment
- Hepatitis B Virus Studies
- RNA Research and Splicing
- Hepatitis C virus research
- Hepatocellular Carcinoma Treatment and Prognosis
- Ubiquitin and proteasome pathways
- Cancer-related gene regulation
- Endoplasmic Reticulum Stress and Disease
- Cancer, Lipids, and Metabolism
- Growth Hormone and Insulin-like Growth Factors
- Cancer Mechanisms and Therapy
- ATP Synthase and ATPases Research
- Mitochondrial Function and Pathology
- Protein Tyrosine Phosphatases
- Thyroid Disorders and Treatments
- Cytokine Signaling Pathways and Interactions
- Autophagy in Disease and Therapy
- Molecular Biology Techniques and Applications
- Cholangiocarcinoma and Gallbladder Cancer Studies
- FOXO transcription factor regulation
Linkou Chang Gung Memorial Hospital
2019-2025
Chang Gung University
2012-2024
Chang Gung Memorial Hospital
2016-2024
Ministry of Health and Welfare
2024
Memorial Hospital of South Bend
2009-2022
National Cheng Kung University
2022
Bile duct cells and hepatocytes differentiate from the same hepatic progenitor cells. To investigate possible association of viral hepatitis B C with intrahepatic cholangiocarcinoma (ICC), we conducted a retrospective case-control study using univariate multivariate logistic analyses to identify risk factors for ICC. Besides lithiasis (25.6%; P<0.001), seropositivity surface antigen (37.5% all ICC patients; odds ratio (OR) =4.985, P<0.001) antibodies (13.1%; OR=2.709; P=0.021) are primary...
Thyroid hormone (T(3)) mediates cellular growth, development, and differentiation by binding to the nuclear thyroid receptor (TR). Recent studies suggest that long-term hypothyroidism is associated with human hepatocellular carcinoma (HCC) independent from other major HCC risk factors. Dickkopf (DKK) 4, a secreted protein, antagonizes Wnt signal pathway. In this study, we demonstrate T(3) may play suppressor role inducing DKK4 expression in cells at both messenger RNA (mRNA) protein levels....
// Ming-Ming Tsai 1, 3, * , Hsiang-Wei Huang 2, Chia-Siu Wang Kam-Fai Lee 4 Chung-Ying 2 Pei-Hsuan Lu 5 Hsiang-Cheng Chi Yang-Hsiang Lin Liang-Mou Kuo 3 Kwang-Huei 6 1 Department of Nursing, Division Basic Medical Sciences and Research Center for Industry Human Ecology, Chang-Gung University Science Technology, Taoyuan, 333, Taiwan Biochemistry, College Medicine, University, General Surgery, Chang Gung Memorial Hospital at Chia-yi, 613, Pathology, Hospital, Dermatology, Taipei, 10508, Liver...
Hepatocellular carcinoma (HCC) accounts for almost 80% of all liver cancer cases and is the sixth most common second cause cancer-related death worldwide. The survival rate sorafenib-treated advanced HCC patients still unsatisfactory. Unfortunately, no useful biomarkers have been verified to predict sorafenib efficacy in HCC.We assessed a resistance-related microarray dataset found that anterior gradient 2 (AGR2) highly associated with overall recurrence-free several clinical parameters HCC....
Glyoxalase I (GLO1), a methylglyoxal detoxification enzyme, is implicated in the progression of human malignancies. The role GLO1 gastric cancer development or currently unclear. expression was determined primary specimens using quantitative polymerase chain reaction, immunohistochemistry (IHC), and western blotting analyses. higher tissues, compared with that adjacent noncancerous tissues. Elevated significantly associated wall invasion, lymph node metastasis, pathological stage, suggesting...
// I-Hsiao Chung 1, * , Tzu-I Wu 3, Chia-Jung Liao 1 Jin-Yo Hu Yang-Hsiang Lin Pei-ju Tai Chyong-Huey Lai 2, 4 Kwang-Huei Department of Biochemistry, School Medicine, Chang-Gung University and Liver Research Center, Chang Gung Memorial Hospital, Taoyuan, Taiwan 333 2 Obstetrics Gynecology, Hospital College 3 Wan Fang Taipei Medical University, Taipei, 116 Gynecologic Cancer These authors have contributed equally to this work Correspondence to: Lin, e-mail: khlin@mail.cgu.edu.tw Keywords:...
// I-Hsiao Chung 1 , Cheng-Yi Chen 2 Yang-Hsiang Lin Hsiang-Cheng Chi Ya-Hui Huang 3 Pei-Ju Tai Chia-Jung Liao Chung-Ying Tsai Syuan-Ling Meng-Han Wu Ching-Ying Kwang-Huei Department of Biochemistry, School Medicine, Chang-Gung University, Taoyuan, Taiwan Medical Research, Mackay Memorial Hospital, Taipei, Liver Research Center, Hepato-Gastroenterology, Linkou, Correspondence to: Lin, e-mail: khlin@mail.cgu.edu.tw Keywords: thyroid hormone receptor, LCN2, Met/FAK cascade Received: December...
Targeting the HGF/MET signaling pathway has been a viable therapeutic strategy for various cancer types due to hyperactivation of axis occurs frequently that leads detrimental progression and recurrence. Deciphering novel molecule mechanisms underlying complex network is therefore critical development effective therapeutics treating MET-dependent malignancies.Using isobaric mass tag-based quantitative proteomics approach, we identified IFITM3, an interferon-induced transmembrane protein was...
Coronavirus disease 2019 (COVID-19) has been a challenging pandemic since late and patients with COVID-19-related severe respiratory failure associated high mortality rates worldwide. Genetic information such as single nucleotide polymorphisms (SNPs) serves predictor or prognostic factor in development cancer progression. This study aimed to explore the clinical associations of SNPs mild COVID-19 symptoms Taiwanese population. SARS-CoV-2-infected pilot cohort (cohort 1, n = 39) validation 2,...
Abstract Anaplastic large-cell lymphoma (ALCL) is a rare type of highly malignant, non-Hodgkin (NHL). Currently, only studies on the chimeric oncogene NPM-ALK have reported link to ALCL progression. However, specific molecular mechanisms underlying invasion are still unclear. Here, we sought investigate differentially expressed, long non-coding RNAs (lncRNAs) in and their potential biological function. Our microarray analyses revealed that LINC01013, novel RNA gene, was expressed clinical...
Anaplastic lymphoma kinase (ALK)-negative anaplastic large-cell (ALCL) is a rare type of highly malignant, non-Hodgkin lymphoma. Currently, only few gene rearrangements have been linked to ALK-negative ALCL progression. However, the specific molecular mechanisms underlying growth tumors remain unclear. Here, we investigated aberrantly expressed, long non-coding RNAs (lncRNAs) in and assessed their potential biological function. MIR503HG (miR-503 host gene) was expressed cell lines...
The thyroid hormone, 3, 3′,5-triiodo-l-thyronine (T3), regulates cell growth, development, differentiation, and metabolism via interactions with hormone receptors (TRs). However, the secreted proteins that are regulated by T3 yet to be characterized. In this study, we used quantitative proteomic approach of stable isotope labeling amino acids in culture coupled nano-liquid chromatography-tandem MS performed on a LTQ-Orbitrap instrument identify characterize T3-regulated human hepatocellular...
Thyroid hormone, 3,3′,5-triiodo-l-thyronine (T3), mediates several physiological processes, including embryonic development, cellular differentiation and cell proliferation, via binding to its nuclear thyroid receptors (TR). Previous microarray Chromatin immunoprecipitation (ChIP)-on-ChIP analyses have revealed that interferon-stimulated gene 20 kDa (ISG20), an exoribonuclease involved in the antiviral function of interferon, is up-regulated by T3 HepG2-TR cells. However, underlying...
BackgroundEnergy metabolism in carcinogenesis is poorly understood. It widely accepted the majority of colorectal cancers (CRCs) arise from adenomatous polyps (APs). We aimed to characterize bioenergetic alterations APs and CRCs.MethodsFifty-six APs, 93 CRCs adjacent normal mucosae were tested. Oxygen consumption rate (OCR) was measured representing mitochondrial oxidative phosphorylation (OxPhos), extracellular acidification (ECAR)was glycolysis. Mitochondrial DNA (mtDNA) variants mutations...
Abstract Aberrant metabolisms have been hypothesized to precede the occurrence of hepatocellular carcinoma (HCC), therefore, we investigated biomarkers associated with subsequent HCC in peripheral bloods using metabolomic technologies. A cohort 475 HCC-naïve liver cirrhotic patients were recruited and prospectively followed. total 39 developed follow-up period. Baseline plasma metabolites explored untargeted nuclear magnetic resonance. Candidates then quantified by ultra-performance liquid...
The oxidative phosphorylation machinery in mitochondria, which generates the main bioenergy pool cells, includes four enzyme complexes for electron transport and ATP synthase. Among them, cytochrome c oxidase (COX), constitutes fourth complex, has been suggested as major regulatory site. Recently, abnormalities COX were linked to tumor progression several cancers. However, it remains unclear whether its subunits play a role of hepatoma. To search key factor(s) hepatoma development, silico...