A5049753044- Atrial Fibrillation Management and Outcomes
- Cardiac electrophysiology and arrhythmias
- Cardiac Arrhythmias and Treatments
- Venous Thromboembolism Diagnosis and Management
- Physiological and biochemical adaptations
- Diabetes Treatment and Management
- Cardiovascular Function and Risk Factors
- Cardiac pacing and defibrillation studies
- Cardiomyopathy and Myosin Studies
- Ion channel regulation and function
- Antiplatelet Therapy and Cardiovascular Diseases
- Acute Ischemic Stroke Management
- Cardiac Fibrosis and Remodeling
- nanoparticles nucleation surface interactions
- Meat and Animal Product Quality
- Cardiovascular Effects of Exercise
- Muscle activation and electromyography studies
- Force Microscopy Techniques and Applications
- Cardiac Imaging and Diagnostics
- Aquaculture Nutrition and Growth
- Cardiac Valve Diseases and Treatments
- Advanced Sensor and Energy Harvesting Materials
- Peptidase Inhibition and Analysis
- Neurobiology and Insect Physiology Research
- Heme Oxygenase-1 and Carbon Monoxide
Medtronic (United States)
2025
Chang Gung University
2015-2024
Chang Gung Memorial Hospital
2015-2024
Linkou Chang Gung Memorial Hospital
2005-2024
Taoyuan Chang Gung Memorial Hospital
2023
Institute of Cardiology
2022
Memorial Hospital of South Bend
2011-2022
University of Nottingham
2017
Montreal Heart Institute
2005-2013
Université de Montréal
2006-2013
<h3>Importance</h3> Non–vitamin K oral anticoagulants (NOACs) are commonly prescribed with other medications that share metabolic pathways may increase major bleeding risk. <h3>Objective</h3> To assess the association between use of NOACs and without concurrent risk in patients nonvalvular atrial fibrillation. <h3>Design, Setting, Participants</h3> Retrospective cohort study using data from Taiwan National Health Insurance database including 91 330 fibrillation who received at least 1 NOAC...
Received 10 December 1963DOI:https://doi.org/10.1103/PhysRevLett.12.150©1964 American Physical Society
Atrial fibrillation (AF), an inflammatory process involving arrhythmia, is associated with severe morbidity and mortality commonly seen in patients diabetes mellitus (DM). The effect of metformin, the most used medication for DM, on AF has not been investigated. primary aim this study was to examine whether metformin prevented occurrence type 2 DM by analyzing a nationwide, population-based dynamic cohort. Additionally, we investigated tachycardia-induced myolysis oxidative stress atrial...
Background— Congestive heart failure (CHF) is a common cause of atrial fibrillation. Focal sources unknown mechanism have been described in CHF-related The authors hypothesized that abnormal calcium (Ca 2+ ) handling contributes to the arrhythmogenic substrate. Methods and Results— CHF was induced dogs by ventricular tachypacing (240 bpm �2 weeks). Cellular Ca -handling properties expression/phosphorylation status key myofilament proteins were assessed control atria. decreased cell...
Background— Pulmonary vein (PV) –encircling radiofrequency ablation frequently is effective in vagal atrial fibrillation (AF), and there evidence that PVs may be particularly prone to cholinergically induced arrhythmia mechanisms. However, PV procedures also can affect intracardiac autonomic ganglia. The present study examined the relative role of versus peri-PV ganglia an experimental AF model. Methods Results— Cholinergic was studied under carbachol infusion coronary perfused canine left...
Rationale: Although connexin changes are important for the ventricular arrhythmic substrate in congestive heart failure (CHF), alterations during CHF-related atrial arrhythmogenic remodeling have received limited attention. Objective: To analyze and their potential contribution to fibrillation (AF) development reversal of CHF. Methods Results: Three groups dogs were studied: CHF induced by 2-week tachypacing (240 bpm, n=15); allowed a 4-week nonpaced recovery interval after (n=16); sham...
Atrial tachycardia (AT) downregulates L-type Ca(2+) current (I(CaL)) and causes atrial fibrillation-promoting electric remodeling. This study assessed potential underlying signal transduction. Cultured adult canine cardiomyocytes were paced at 0, 1, or 3 Hz (P0, P1, P3) for up to 24 hours. Cellular tachypacing (P3) mimicked effects of in vivo AT: decreased I(CaL) transient outward (I(to)), unchanged I(CaT), I(Kr), I(Ks), reduced action duration (APD). was P3 2 8 hours but by 55+/-6%...
There is evidence suggesting that heat shock proteins (HSPs) may protect against clinical atrial fibrillation (AF). We evaluated the effect of HSP induction in an vitro cell line (HL-1) model tachycardia remodeling and tachypaced isolated canine cardiomyocytes. also on vivo AF promotion by tachycardia-induced dogs. Tachypacing (3 Hz) significantly progressively reduced Ca 2+ transients shortening HL-1 myocytes over 4 hours. These reductions were prevented HSP-inducing pretreatments: mild...
It is unclear whether the non–vitamin K antagonist oral anticoagulant agents rivaroxaban and dabigatran are superior to warfarin for efficacy safety outcomes in Asians with nonvalvular atrial fibrillation (NVAF). The aim of this study was compare risk thromboembolic events, bleeding, mortality associated versus NVAF. A nationwide retrospective cohort conducted consecutive patients NVAF taking (n = 3,916), 5,921), or 5,251) using data collected from Taiwan National Health Insurance Research...
Whether non-vitamin K antagonist oral anticoagulants (NOACs) are superior to warfarin among Asians with nonvalvular atrial fibrillation remains unclear.In this nationwide retrospective cohort study collected from Taiwan National Health Insurance Research Database, there were 5843, 20 079, 27 777, and 19 375 patients taking apixaban, dabigatran, rivaroxaban warfarin, respectively, June 1, 2012 December 31, 2016. Propensity-score weighting was used balance covariates across groups. Patients...
Background— Sinoatrial node (SAN) dysfunction is frequently associated with atrial tachyarrhythmias (ATs). Abnormalities in SAN pacemaker function after termination of ATs can cause syncope and require implantation, but underlying mechanisms remain poorly understood. This study examined the hypothesis that impair by altering ion channel expression. Methods Results— tissues were obtained from 28 control dogs 31 7-day tachypacing (400 bpm). Ionic currents measured single cells whole-cell...
Abstract Background Insulin resistance (IR) is considered as a risk factor for atrial fibrillation (AF) even before diabetes develops. The pathophysiology and underlying mechanism are largely unclear. Methods We investigated the corresponding in two IR models of rats fed 15-week high-fat (HFa) high-fructose/cholesterol (HFr) diets. AF was evaluated induced by burst pacing. Isolated myocytes were used whole-cell patch clamp calcium assessment. Ex vivo whole heart optical mapping. Western blot...
Background Liver cirrhotic patients with nonvalvular atrial fibrillation have been excluded from randomized clinical studies regarding oral anticoagulants for stroke prevention. Whether non–vitamin K antagonist ( NOAC s) are superior to warfarin these remains unclear. Methods and Results This nationwide retrospective cohort study, data collected the Taiwan National Health Insurance Research Database, enrolled 2428 liver taking apixaban (n=171), dabigatran (n=535), rivaroxaban (n=732), or...
Atrial fibrosis is an essential contributor to atrial fibrillation (AF). It remains unclear whether endocardial endothelial cells (AEECs) that undergo endothelial-mesenchymal transition (EndMT) are among the sources of fibroblasts. We studied human atria, TGF-β-treated AEECs, cardiac-specific TGF-β-transgenic mice, and heart failure rabbits identify underlying mechanism EndMT in fibrosis. Using isolated we found miR-181b was induced which decreased semaphorin 3A (Sema3A) increased markers,...
Abstract Background The novel sodium-glucose co-transporter 2 inhibitor (SGLT2i) potentially ameliorates heart failure and reduces cardiac arrhythmia. Cardiac fibrosis plays a pivotal role in the pathophysiology of HF atrial myopathy, but effect SGLT2i on fibrogenesis remains to be elucidated. This study investigated whether directly modulates fibroblast activities its underlying mechanisms. Methods results Migration, proliferation analyses, intracellular pH assay, inositol triphosphate...
Background— Atrial fibrillation impairs atrial contractility, inducing stunning that promotes thromboembolic stroke. Action potential (AP)-prolonging drugs are reported to normalize hypocontractility caused by tachycardia remodeling (ATR). Here, we addressed the role of AP duration (APD) changes in ATR-induced hypocontractility. Methods and Results— ATR (7-day tachypacing) decreased APD (perforated patch recording) ≈50%, contractility (echocardiography, cardiomyocyte video edge detection),...
Whether dabigatran is associated with different risks of cardiovascular, bleeding events, and mortality from warfarin in Asian patients nonvalvular atrial fibrillation remains unclear.We used the Taiwan National Health Insurance Research Database to obtain 9940 9913 taking warfarin, respectively, June 1, 2012, December 31, 2013, as dynamic cohort. Inverse probability treatment weighting using propensity scores was balance covariates across 2 study groups. Patients were followed up until...
Whether dabigatran is associated with a lower risk of acute kidney injury (AKI) in patients nonvalvular atrial fibrillation (NVAF) remains unknown. The authors compared the AKI Asians NVAF who were prescribed versus warfarin. analyzed enrolled Taiwan nationwide retrospective cohort study from June 1, 2012, to December 31, 2013. Dabigatran and warfarin taken by 7,702 7,885 without history chronic disease (CKD) 2,256 2,089 CKD, respectively. A propensity-score weighted method was used balance...