A5016966735- Lymphoma Diagnosis and Treatment
- Biomarkers in Disease Mechanisms
- Connective Tissue Growth Factor Research
- Monoclonal and Polyclonal Antibodies Research
- Education and Critical Thinking Development
- Chronic Lymphocytic Leukemia Research
- T-cell and Retrovirus Studies
- Immune Cell Function and Interaction
- Viral-associated cancers and disorders
- Science Education and Pedagogy
- Career Development and Diversity
- Lung Cancer Treatments and Mutations
- Glycosylation and Glycoproteins Research
- Fungal Biology and Applications
- Cytokine Signaling Pathways and Interactions
- Youth Development and Social Support
- Innovative Teaching and Learning Methods
- Antimicrobial Peptides and Activities
- Eosinophilic Disorders and Syndromes
- Endometriosis Research and Treatment
- Diverse Educational Innovations Studies
- Ubiquitin and proteasome pathways
- Educational Strategies and Epistemologies
- Cutaneous lymphoproliferative disorders research
- Syphilis Diagnosis and Treatment
Kaohsiung Medical University
2008-2024
Kaohsiung Medical University Chung-Ho Memorial Hospital
2008-2024
National Cheng Kung University
2013-2022
University of North Carolina at Chapel Hill
2017-2020
China Medical University
2020
Institute of Basic Medical Sciences of the Chinese Academy of Medical Sciences
2016-2019
The University of Texas at El Paso
2019
Communities In Schools of Orange County
2017
University of Toronto
2014
Taiwan Food and Drug Administration
2009
Endometriosis is a highly prevalent gynecological disease with severe negative impacts on life quality and financial burden. Unfortunately, there no cure for this disease, which highlights the need further investigation about pathophysiology of to provide clues developing novel therapeutic regimens. Herein, we identified that vascular endothelial growth factor (VEGF)-C, potent lymphangiogenic factor, up-regulated in endometriotic cells contributes increased lymphangiogenesis. Bioinformatic...
Atherosclerosis occurs preferentially at the blood vessels encountering flow turbulence. The matricellular protein CCN1 is induced in endothelial cells by disturbed flow, and expressed advanced atherosclerotic lesions patients Apoe-/- mouse model. role of atherosclerosis remains undefined.To assess function vivo, knock-in mice carrying integrin α6β1-binding-defective mutant allele Ccn1-dm on background were tested an model generated carotid artery ligation. Additionally, CCN1-regulated...
Comorbidity exists between metabolic disorders and depressive syndrome with unclear mechanisms. To characterize the causal relationship, we adopted a 12-week high-fat diet (HFD) to induce disorder phenotypes in mice. Initially, identified an enhanced glutamatergic input nucleus accumbens of HFD Retrograde tracing chemogenetic inhibition showed that hyperactive ventral hippocampal afferents determined exhibition depression-like behavior Using lentiviral knockdown overexpression approaches,...
Metastasis is the main cause of death in many cancers including colorectal cancer (CRC); however, underlying mechanisms responsible for metastatic progression remain largely unknown. We found that nuclear TYRO3 receptor tyrosine kinase a strong predictor poor overall survival patients with CRC. The metastasis-promoting function requires its activity and matrix metalloproteinase-2 (MMP-2)-mediated cleavage but independent ligand binding. Using proteomic analysis, we identified...
The strong hemolytic toxicity of pulsatilla saponin D (1, HD50 6.3 μM) has hampered its clinical development as an injectable anticancer agent. To combat this challenge, 17 new derivatives 1 with ring C, C-28, or C-3 modifications were synthesized and evaluated for cytotoxicity against several selected human tumor lines, well rabbit erythrocytes. Structure–activity relationship (SAR) structure–toxicity (STR) correlations also elucidated. Compared to the lead compound 1, activity all dropped...
ABSTRACT Early dissemination is a unique characteristic and detrimental process of pancreatic ductal adenocarcinoma (PDAC); however, the underlying mechanism remains largely unknown. Here, we investigate role dual‐specificity phosphatase‐2 (DUSP2)‐vascular endothelial growth factor‐C (VEGF‐C) axis in mediating PDAC lymphangiogenesis lymphovascular invasion. Expression DUSP2 greatly suppressed PDAC, which results increased aberrant expression extracellular vesicle (EV)‐associated VEGF‐C...
Abstract Monocytes are a major population of circulating immune cells that play crucial role in producing pro-inflammatory cytokines the body. The actions monocytes known to be influenced by combinations and concentrations certain fatty acids (FAs) blood dietary fats. However, systemic comparisons effects FAs on cytokine secretion have not performed. In this study, we compared how six saturated (SFAs), two monounsaturated (MUFAs), seven polyunsaturated (PUFAs) modulate human THP-1 monocyte...
Light and electron microscopic immunoperoxidase studies show no detectable immunoglobulin determinants in the Russell body cores. Denaturation of antigens during tissue preparation appears to be an unlikely explanation, since immunoglobulins cytoplasm plasma cells are clearly demonstrated. The presence on surface small intracellular bodies may represent surrounding rough endoplasmic reticulum. It seems likely that contain non-immunoglobulin molecules, by-products synthesis, or some altered...
By the immunoperoxidase technique, immunoglobulin A(IgA) was demonstrated in 50% of human hepatocytes. The positively stained cells showed a tendency towards periportal clustering. Very few plasma were identified liver. intrahepatocyte IgA is most probably derived from serum and on its way to bile ducts. Secretory component (SC) had same distribution as that IgA. presence SC hepatocytes reflects either synthesis or transport pre-assembled SC-IgA by liver cells. significance transfer into yet...
Objective: Gastric cancer with peritoneal metastasis is considered to be final stage gastric cancer. One current treatment approach for this condition combined cytoreductive surgery hyperthermic intraperitoneal chemotherapy (HIPEC). However, the therapeutic mechanisms of HIPEC remain largely undescribed. Method: In order assess cellular effects in vitro, we treated AGS human adenocarcinoma cells or without 5-fluorouracil (5-Fu) at 37 °C 43 (hyperthermic temperature) 1 h followed by...
7-Methoxy-4-(2-methylquinazolin-4-yl)-3,4-dihydroquinoxalin-2(1H)-one (2), a promising anticancer lead previously identified by us, inhibited tumor growth 62% in mice at 1.0 mg/kg without obvious signs of toxicity. Moreover, compound 2 exhibited extremely high antiproliferative activity the NIH-NCI 60 human cell line panel, with low to sub-nanomolar GI50 values (10-10 M level). It also showed suitable balance between aqueous solubility and lipophilicity, as well moderate metabolic stability...
Rationale: Endometriosis is a highly prevalent gynecological disease in women of reproductive age that markedly reduces life quality and fertility.Unfortunately, there no cure for this disease, which highlights more efforts are needed to investigate the underlying mechanism designing novel therapeutic regimens.This study aims druggable membrane receptors distinctively expressed endometriotic cells.Methods: Bioinformatic analysis public databases was employed identify potential...
The complete primary amino acid sequence for the 47-kilodalton (kDa) major integral membrane immunogen of Treponema pallidum subsp. was obtained by using a combined strategy DNA sequencing (of cloned gene in Escherichia coli) and N-terminal native (T. pallidum-derived) antigen. An open reading frame believed to encode 47-kDa antigen comprised 367 codons, which gave rise calculated molecular weight corresponding 40,701. Of acids, 113 (31%) were sequenced trypsin hydroxylamine cleavage...