A5058049360- Cancer, Hypoxia, and Metabolism
- Endometriosis Research and Treatment
- Glioma Diagnosis and Treatment
- Prostate Cancer Treatment and Research
- Chromatin Remodeling and Cancer
- Epigenetics and DNA Methylation
- Uterine Myomas and Treatments
- Mitochondrial Function and Pathology
- Neuroblastoma Research and Treatments
- Cancer, Lipids, and Metabolism
- Cancer-related molecular mechanisms research
- Ubiquitin and proteasome pathways
- Estrogen and related hormone effects
- MicroRNA in disease regulation
- RNA modifications and cancer
- Protein Tyrosine Phosphatases
- Reproductive System and Pregnancy
- ATP Synthase and ATPases Research
- Endometrial and Cervical Cancer Treatments
- Circular RNAs in diseases
- Meningioma and schwannoma management
- Lung Cancer Diagnosis and Treatment
- Head and Neck Cancer Studies
- Protein Degradation and Inhibitors
- Hippo pathway signaling and YAP/TAZ
National Cheng Kung University
2016-2025
Taipei Veterans General Hospital
2007-2024
National Yang Ming Chiao Tung University
2011-2021
Institute of Molecular Medicine
2019
West Los Angeles College
2018
Baylor College of Medicine
2004-2017
National Cheng Kung University Hospital
2014-2016
University of North Carolina at Chapel Hill
2016
Chang Gung University
2011-2016
National Defense Medical Center
2016
The switch of cellular metabolism from mitochondrial respiration to glycolysis is the hallmark cancer cells and associated with tumor malignancy. However, mechanism this metabolic remains largely unknown. Herein, we reported that hypoxia-inducible factor-1 (HIF-1) induced pyruvate dehydrogenase kinase-3 (PDK3) expression leading inhibition respiration. Promoter activity assay, small interference RNA knockdown chromatin immunoprecipitation assay demonstrated hypoxia-induced PDK3 gene was...
The switch of cellular metabolism from mitochondrial respiration to glycolysis is the hallmark cancer cells and associated with tumor malignancy. Pyruvate dehydrogenase kinase-1 (PDK1) PDK3 participate in metabolic cells; however, medical significance PDK1 progression not known. Here, we assessed expression profiles colorectal cancer. Western blot analysis (n = 74) demonstrated that was markedly increased colon compared adjacent normal tissues, whereas decreased cells. In addition,...
Abstract Context: Aberrant activation of MAPK has been implicated to play important roles in pathological processes endometriosis. However, how are constitutively activated endometriotic tissues remains largely unknown. microRNA small noncoding RNA that regulate the stability or translational efficiency target mRNA by interacting with 3′ untranslated region. Thus, miRNA thought be modulators transcriptional response, fine-tuning gene expression. Objective: The aim this study was evaluate...
Abstract Although early detection and treatment of prostate cancer (PCa) improves outcomes, many patients still die metastatic PCa. Here, we report that PCa exhibits reduced levels the microRNAsmiR-101 miR-27a. These micro-RNAs (miRNAs) negatively regulate cell invasion inhibit expression FOXM1 CENPF, two master regulators metastasis in Interestingly, repression CENPF by these miRNAs occurs through COUP-TFII, a member orphan nuclear receptors family. Loss miR-101 positively correlates with...
Metastatic castration-resistant prostate cancer (mCRPC) is a malignant and lethal disease caused by relapse after androgen-deprivation (ADT) therapy. Since enzalutamide innovated approved US FDA as new treatment option for mCRPC patients, drug resistance critical issue during clinical usage. Although several underlying mechanisms causing were previously identified, most of them revealed that resistant cells are still highly addicted to androgen AR functions. Due the numerous physical...
Hypoxia inducible factor-1 (HIF-1) is the master transcriptional regulator of cellular response to altered oxygen levels. HIF-1α protein elevated in most solid tumors and contributes poor disease outcome by promoting tumor progression, metastasis, resistance chemotherapy. To date, relationship between HIF-1 these processes, particularly chemoresistance, has remained largely unexplored. Here, we show that expression MAPK-specific phosphatase dual-specificity phosphatase-2 (DUSP2) markedly...
Antiviral therapy can prevent the development of hepatocellular carcinoma (HCC) in chronic hepatitis C (CHC) patients. However, HCC still develops patients achieving sustained virological response (SVR). We proposed to evaluate risk factors and derive a novel score for (scoreHCC) by summation products clinical weights based on regression coefficients final proportional hazards model. From March 2002 October 2009, we enrolled 871 with biopsy-proven CHC, who received combined pegylated...
A major clinical hurdle for the management of advanced prostate cancer (PCa) in patients is resistance tumors to androgen deprivation therapy (ADT) and their subsequent development into castration-resistant (CRPC). While recent studies have identified potential pathways involved CRPC development, drivers remain largely undefined. Here we determined that nuclear receptor coactivator 2 (NCoA2, also known as SRC-2), which frequently amplified or overexpressed with metastatic PCa, mediates CRPC....
// Pi-Lin Sung 1, 2 , Yi-Hua Jan 3 Shih-Chieh Lin 4 Chao-Cheng Huang 5 Hao 6 Kuo-Chang Wen Kuan-Chong Chao Chiung-Ru Lai Peng-Hui Wang Chi-Mu Chuang Hua-Hsi Wu Nae-Fang Twu Ming-Shyen Yen Michael Hsiao Chi-Ying F. 7 1 Institute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan Department Obstetrics and Gynecology, Taipei Veterans General Hospital, School Genomics Research Center, Academia Sinica, Pathology, Kaohsiung Chang Gung Memorial Hospital University College...
// Muh-Lii Liang 1,2,* , Tsung-Han Hsieh 3,4,* Kim-Hai Ng 5 Ya-Ni Tsai Cheng-Fong 6 Meng-En Chao 7,8 Da-Jung Liu 2 Shing-Shiung Chu Wan Chen Yun-Ru 4,9 Ren-Shyan 10,11,12 Shih-Chieh Lin 13 Donald Ming-Tak Ho 10,13 Tai-Tong Wong 2,7,8,9 Muh-Hwa Yang 1,14,15,16,17 and Hsei-Wei Wang 1,5,6,14 1 Institutes of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan Division Pediatric Neurosurgery, Neurological Institute, Taipei Veterans General Hospital, 3 PhD Program for Cancer Biology...
MRI is used to image prostate cancer and target tumors for biopsy or therapeutic ablation. The objective was understand the biology of not visible on that may go undiagnosed untreated. Methods: Prostate cancers invisible multiparametric were macrodissected examined by RNAseq. Differentially expressed genes (DEGs) based visibility status cross-referenced with publicly available gene expression databases identify associated disease progression. Genes potential roles in determining progression...
Cancer stem-like cells (CSC) evolve to overcome the pressures of reduced oxygen, nutrients or chemically induced cell death, but mechanisms driving this evolution are incompletely understood. Here, we report that hypoxia-mediated downregulation dual specificity phosphatase 2 (DUSP2) is critical for accumulation CSC in colorectal cancer. Reduced expression DUSP2 led overproduction COX-2-derived prostaglandin E2, which promoted cancer stemness via EP2/EP4 signaling pathways. Genetic and...
Although boron neutron capture therapy (BNCT) is a promising treatment option for malignant brain tumors, the optimal BNCT parameters patients with immediately life-threatening, end-stage tumors remain unclear. We performed on 34 and analyzed relationship between survival outcomes parameters. Before BNCT, MRI 18F-BPA-PET analyses were conducted to identify tumor location/distribution tumor-to-normal tissue uptake ratio (T/N ratio) of 18F-BPA. No severe adverse events observed (grade ≥ 3)....
Metastasis is the main cause of death in many cancers including colorectal cancer (CRC); however, underlying mechanisms responsible for metastatic progression remain largely unknown. We found that nuclear TYRO3 receptor tyrosine kinase a strong predictor poor overall survival patients with CRC. The metastasis-promoting function requires its activity and matrix metalloproteinase-2 (MMP-2)-mediated cleavage but independent ligand binding. Using proteomic analysis, we identified...
STUDY QUESTIONHow does hypoxia-mediated down-regulation of dual specificity phosphatase-2 (DUSP2) promote endometriotic lesion development?
Mitochondrial pyruvate carrier 1 (MPC1) and MPC 2 form a transporter complex in cells to control transportation into mitochondria. Reduced expression of MPC1 disrupts the function, induces metabolic shift increase glycolysis, thus plays important roles several diseases, including cancer. However, role prostate cancer underlying mechanism causing down-regulation tumor remain be defined. Here, we show that serves as critical regulator glycolysis cells, which turn controls cell growth,...
Abstract STUDY QUESTION Does YAP1 inhibition alleviate progesterone resistance in endometriosis? SUMMARY ANSWER reduces vitro and vivo. WHAT IS KNOWN ALREADY Progesterone not only causes treatment failure for endometriosis but also inhibits eutopic endometrial cell proliferation, dysregulates decidualization, the success rates of pregnancy. Hippo/yes-associated protein 1 (YAP1) signaling pathway plays an important role pathogenesis endometriosis. DESIGN, SIZE, DURATION Paraffin-embedded...
Melatonin protects against transient middle cerebral artery (MCA) occlusion and may be suited as an add-on therapy of tissue plasminogen activator (t-PA) thrombolysis. Herein, we examined whether melatonin would reduce postischemic increase in the blood-brain barrier (BBB) permeability and, therefore, attenuate risk hemorrhagic transformation after t-PA experimental stroke. Twelve mice were subjected to MCA for 1 hr, followed by 24 hr reperfusion. (5 mg/kg, i.p.) or vehicle was given at...
The first step of metastasis is the detachment cancer cells from surrounding matrix and neighboring cells; however, how accomplish this process remains unclear. Thus, we aimed to investigate underlying mechanism that controls early event metastasis.One hundred thirty-seven paired colorectal carcinoma normal colon tissues were examined by immunohistochemical staining Western blot for expression CD151, a member tetraspanin family plays important roles in cell adhesion motility. effect CD151 on...
Abstract BACKGROUND: Previous intracranial germinoma (IG) studies have investigated the effect of different radiotherapy (RT) volumes and necessity for adjunctive chemotherapy, but there is currently no consensus on best treatment this tumor. METHODS: From January 1989 to December 2009, 80 IG patients (≤20 years old) were treated with various RT regimens. Of them, 14 had craniospinal irradiation (CSI) + primary boost (PB); 8 whole‐brain (WBI) PB; 31 whole ventricular (WVI) 27 focal only....