A5061568154- Genetic factors in colorectal cancer
- Cancer Genomics and Diagnostics
- Cancer, Lipids, and Metabolism
- Immune Cell Function and Interaction
- Cancer Immunotherapy and Biomarkers
- DNA Repair Mechanisms
- Glycosylation and Glycoproteins Research
- Monoclonal and Polyclonal Antibodies Research
- Immune cells in cancer
- Cancer-related molecular mechanisms research
- Inflammatory Biomarkers in Disease Prognosis
- Immunotherapy and Immune Responses
- Cancer, Hypoxia, and Metabolism
- Galectins and Cancer Biology
- Ferroptosis and cancer prognosis
- MicroRNA in disease regulation
- RNA modifications and cancer
- Immunodeficiency and Autoimmune Disorders
- RNA Interference and Gene Delivery
- Cancer Treatment and Pharmacology
- Lung Cancer Treatments and Mutations
- Radiomics and Machine Learning in Medical Imaging
- Circular RNAs in diseases
- Angiogenesis and VEGF in Cancer
- Cancer, Stress, Anesthesia, and Immune Response
Affiliated Hospital of Jining Medical University
2018-2024
Wannan Medical College
2024
Cedars-Sinai Medical Center
2010-2024
Jilin Province Tumor Hospital
2020-2024
Sichuan University
2016-2023
West China Hospital of Sichuan University
2023
Jinzhou Medical University
2020-2022
ORCID
2021
Aerospace Center Hospital
2021
Chongqing Medical University
2018-2020
MRI is used to image prostate cancer and target tumors for biopsy or therapeutic ablation. The objective was understand the biology of not visible on that may go undiagnosed untreated. Methods: Prostate cancers invisible multiparametric were macrodissected examined by RNAseq. Differentially expressed genes (DEGs) based visibility status cross-referenced with publicly available gene expression databases identify associated disease progression. Genes potential roles in determining progression...
Soluble forms of the human immunodeficiency virus type 1 (HIV-1) primary receptor CD4 (soluble [sCD4]) have been extensively characterized for a quarter century as promising HIV-1 inhibitors, but they not clinically successful. By combining protein cavity-filling strategy and power library technology, we identified an engineered cavity-altered single-domain sCD4 (mD1.22) with unique combination excellent properties, including broad potent neutralizing activity, high specificity, stability,...
// Ling Deng 1, * , Qianqian Lei 2, Yu Wang 1 Zhu Guiqin Xie Xiaorong Zhong Yanping Nianyong Chen 3 Yan Qiu 4 Tianjie Pu Hong Bu and Zheng Laboratory of Molecular Diagnosis Cancer, Clinical Research Center for Breast, State Key Biotherapy, National Collaborative Innovation West China Hospital, Sichuan University, Chengdu, 2 Department Radiation Oncology, Chongqing Cancer Institute & Hospital Center, Chongqing, center, Pathology, These authors share co-first authorship Correspondence to:...
The impact of the immune landscape microenvironment on cancer progression is not well understood for triple-negative breast (TNBC). We, therefore, aimed to examine association cell enrichment scores as a proxy profiles tumor with TNBC prognosis.We included 76 patients diagnosed between 2008 2016 in West China Hospital and 158 from Cancer Genome Atlas. On basis transcriptome data, we calculated overall ImmuneScore type-specific 34 types cells, using xCell, gene signature-based method. HRs...
Abstract Melanoma differentiation–associated gene-7 (mda-7)/interleukin-24 (IL-24) is a cancer-specific, apoptosis-inducing gene with broad-spectrum antitumor activity, making it an ideal candidate for novel cancer therapy. A systemic and sustained immune response generated at the time of initial molecular-targeted therapy would provide additional clinical benefits in patients, resulting improved prevention tumor recurrence. In this study, we explored therapeutic efficacy intratumoral...
Glycosphingolipids (GSLs) are information-bearing biomolecules that play critical roles in embryonic development, signal transduction and carcinogenesis. Previous studies indicate certain GSLs associated with differentiation acute myeloid leukemia (AML) cells. In this study, we collected bone marrow samples from healthy donors AML patients analyzed the GSL expression profiles comprehensively using electrospray ionization linear ion-trap mass spectrometry. The results showed had higher of...
CD40 ligand (CD40L) deficiency is a rare but life-threatening primary immunodeficiency caused by mutations in the CD40L gene. Here, we investigated cohort of 40 genetically diagnosed CD40L-deficient patients from Chinese mainland, analysed their clinical and genetic data, examined expression, proportion T cell subsets, B subsets follicular helper (Tfh) cells. The aim was to provide complete picture deficiency. Initial presentations patient mainly involved recurrent fever (47.5%)...
Abstract Purpose: There is a need for strategies to prevent prostate cancer. Cholesterol-lowering interventions are employed widely and safely reduce risk of cardiovascular disease has been proposed chemoprevention. Using preclinical models window-of-opportunity clinical trial, we describe an adaptive antitumor immunity resulting from cholesterol lowering. Experimental Design: Statins do not reliably lower serum in mice. Therefore, oral ezetimibe was administered mice clinically relevant...
ABSTRACT Soluble forms of the HIV-1 receptor CD4 (sCD4) have been extensively characterized for more than 2 decades as promising inhibitors and components vaccine immunogens. However, they were mostly based on first two domains (D1D2), numerous attempts to develop functional, high-affinity, stable soluble one-domain sCD4 (D1) not successful because strong interactions between domains. We hypothesized that combining power structure-based design with sequential panning large D1 mutant...
Bispecific killer cells engagers (BiKEs) which can bind to natural (NK) through the activating receptor CD16A and guide them expressing HIV-1 envelope glycoprotein (Env) are a promising new weapon for elimination of infected eradication virus. Here we report design, generation characterization BiKEs consist binding human antibody domains fused flexible linker an engineered one-domain soluble CD4. In presence glycoproteins (Envs), these activated specifically CD16A-expressing Jurkat T cells,...
// Yuxin Xie 1, 2, * , Qiheng Gou Keqi 3 Zhu Wang 4 Yanping Hong Zheng 1 Departments of Head and Neck Mammary Gland Oncology, Medical Cancer Center, West China Hospital, Sichuan University, Chengdu, 610041, P. R. 2 State Key Laboratory Biotherapy/Collaborative Innovation Center Biotherapy, P.R. Department Anesthesiology, Mianyang Central Mianyang, Sichuan, 621000, Molecular Diagnosis Cancer, These authors contributed equally to this work Correspondence to: Zheng, email: hzheng@scu.edu.cn...
Aberrant glycosylation is highly associated with cancer progression. The aim of this study was to compare bifucosylated N-glycans in sera obtained from healthy controls and breast patients, the goal identifying a potential indicator for monitoring recurrence metastasis cancer. A unique structural pattern N-glycan, both core antennary fucosylation, identified patients. spectrum fucosylation composite standard spectra Lewis X H2, indicating mixture two epitopes. Permethylated glycoproteins...
Abstract Background Lymph node metastasis is a major prognostic sign of colorectal carcinoma and an important indicator for individualized treatment. M2 macrophages play key role in carcinogenesis tumor development by enhancing invasiveness promoting lymph metastasis. The purpose this study was to investigate the effect CD163-positive on carcinoma. Methods Postoperative tissues were obtained from 120 patients with who underwent radical surgery First Affiliated Hospital Jinzhou Medical...
AIMTo investigate the functional role and underlying molecular mechanism of miR-29a in hepatitis B virus (HBV) expression replication. METHODSThe levels SMARCE1 HBV-infected HepG2.2.15 cells were measured by quantitative real-time PCR western blot analysis.HBV DNA replication was Southern analysis.The relative surface antigen e detected enzyme-linked immunosorbent assay.The Cell Counting Kit-8 (CCK-8) used to detect viability cells.The relationship between identified target prediction...
Gastric cancer is the fourth most common malignant worldwide. Important for tumorigenesis and progression, aberrant glycosylation occurs frequently in cancers. We investigated differences O-glycosylation serum of 157 gastric patients (GC) 144 healthy donors.We used method labeling O-glycans (released from proteins) with 1-phenyl-3-methyl-5-pyrazolone followed by LC-MS analysis. Analyzing data partial least squares discriminant unpaired Student t test, combined structural information LC-MS/MS...
Activated phosphoinositide 3-kinase δ syndrome 1 (APDS1) is a primary immunodeficiency disease caused by gain-of-function mutations in PIK3CD. Clinical features of autoimmune have been reported patients with APDS1. In this study, we three APDS1 presenting systemic lupus erythematosus (SLE) phenotype. The clinical manifestations included recurrent respiratory tract infection, lymphoproliferation, Coombs-positive hemolytic anemia, decreased complement fractions, positive antinuclear...
Excess copper induces cell death by binding to lipoylated components of the tricarboxylic acid cycle. Although a few studies have examined relationship between cuproptosis-related genes (CRGs) and breast cancer prognosis, reports on estrogen receptor-positive (ER+) are lacking. Herein, we aimed analyze CRGs outcomes in patients with ER+ early (EBC). We conducted case-control study among EBC presenting poor favorable invasive disease-free survival (iDFS) at West China Hospital. Logistic...
This experimental study aims to observe whether the protective effect of propofol against renal ischemia-reperfusion injury (IRI) in rat interlobar artery occurs through altered expression gap junction protein connexin 43 (Cx43).This randomly divided male Sprague Dawley (SD) rats into an untreated control group, a sham-operated group (sham group), (IR (propofol+IR group) and fat emulsion (Intralipid group). The ischemia/reperfusion model was prepared resection right kidney noninvasive...
Purpose: Lymph node metastasis is one of the important prognostic factors colorectal cancer, and an index individualized treatment. The purpose this study to use metabonomics identify potential molecular markers lymph in cancer (CRC). Patients Methods: Peripheral blood samples 223 CRC patients were collected. metabolic levels amino acids carnitine peripheral patients, with without metastasis, analyzed by liquid chromatography-tandem mass spectrometry (LC-MS/MS). Results: results show that...