A5101748238- Nanoparticle-Based Drug Delivery
- RNA Interference and Gene Delivery
- Functional Brain Connectivity Studies
- Nanoplatforms for cancer theranostics
- Advanced Drug Delivery Systems
- Advanced Neuroimaging Techniques and Applications
- Advanced MRI Techniques and Applications
- Graphene and Nanomaterials Applications
- Immune Cell Function and Interaction
- Advanced biosensing and bioanalysis techniques
- Layered Double Hydroxides Synthesis and Applications
- Neuroendocrine regulation and behavior
- Ammonia Synthesis and Nitrogen Reduction
- Face Recognition and Perception
- Hydrogels: synthesis, properties, applications
- Pregnancy-related medical research
- Medicinal Plants and Bioactive Compounds
- Glutathione Transferases and Polymorphisms
- Micro and Nano Robotics
- Neurotransmitter Receptor Influence on Behavior
- Gastric Cancer Management and Outcomes
- Silymarin and Mushroom Poisoning
- Photodynamic Therapy Research Studies
- Multiple Myeloma Research and Treatments
- Synthesis and bioactivity of alkaloids
Chengdu University
2025
Sichuan University
2025
Yantaishan Hospital
2022
Nanjing University of Chinese Medicine
2021
Kunming Medical University
2021
Center of Hubei Cooperative Innovation for Emissions Trading System
2019-2020
Wuhan University
2014-2020
Jiyang College of Zhejiang A&F University
2020
Shengli Oilfield Central Hospital
2014-2019
Zhejiang Ocean University
2019
Multifunctional nanocomposites hold great potential to integrate therapeutic and diagnostic functions into a single nanoscale structure. In this paper, we prepared the MTX-PEG-CS-IONPs-Cy5.5 by functionalizing surface of chitosan-decorated iron oxide nanoparticles (CS-IONPs) with polyethylene glycolated methotraxate (MTX-PEG) near-infrared fluorescent cyanin dye (Cy5.5). A clinically useful PEGylated anticancer prodrug, MTX-PEG, was also developed as tumor cell-specific targeting ligand for...
Codelivery of multiple drugs with one kind drug carriers provided a promising strategy to suppress the resistance and achieve synergistic therapeutic effect in cancer treatment. In this paper, we successfully developed both methotrexate (MTX) mitomycin C (MMC) loaded PEGylated chitosan nanoparticles (CS-NPs) as delivery systems, which MTX, folic acid analogue, was also employed tumor-targeting ligand. The new systems can coordinate early phase targeting late-phase anticancer effect....
Most present drug-phospholipid delivery systems were based on a water-insoluble complex but rarely water-soluble complex. Mitomycin C (MMC) is anticancer drug extensively used in first-line chemotherapy limited by its poor aqueous stability vitro, rapid elimination from the body, and lack of target specificity. In this article, we report MMC-soybean phosphatidylcholine complex-loaded PEG-lipid-PLA hybrid nanoparticles (NPs) with Folate (FA) functionalization (FA-PEG-PE-PLA NPs@MMC-SPC) for...
Strong metal–support interaction (SMSI) over Ru/CaAlO<sub>x</sub> was constructed by utilizing the surface structural reconstruction of Ca–Al layered double hydroxides (LDHs) in aqueous solution and their subsequent hydroxide-to-oxide transformations.
We constructed 10-hydroxycamptothecin (CPT) "nanodrugs" with functionalization of lipid-PEG-methotrexate (MTX) to prepare high-drug-loaded, and sustained/controlled-release MTX-PEG-CPT nanorods (NRs), in which MTX drug itself can serve as a specific "targeting ligand". The self-targeted nanodrug codeliver both CPT drugs distinct anticancer mechanisms. Furthermore, NRs significantly reduced burst release, improved blood circulation tumor accumulation, enhanced cellular uptake, synergistically...
The design of nanoscale drug delivery systems for the targeted codelivery multiple therapeutic drugs still remains a formidable challenge (ACS Nano, 2013, 7, 9558–9570; ACS 9518–9525). In this article, both mitomycin C (MMC) and methotrexate (MTX) loaded DSPE-PEG micelles (MTX–M–MMC) were prepared by self-assembly using dialysis technique, in which MMC–soybean phosphatidylcholine complex (drug–phospholipid complex) was encapsulated within MTX-functionalized micelles. MTX–M–MMC could...
A mitomycin C (MMC)-soybean phosphatidyhlcholine complex loaded in phytosomes was previously reported for the purpose of developing a MMC drug delivery system (Mol. Pharmaceutics 2013, 10, 90-101), but this approach limited by rapid elimination from body and lack target specificity. In article, to overcome these limitations, MMC-soybean complex-loaded (MMC-loaded phytosomes) as carriers were surface-functionalized with folate-PEG (FA-PEG) achieve reduced toxicity superior MMC-mediated...
The NOD-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome is an important mediator of neuroinflammatory responses that regulates inflammatory injury following cerebral ischemia and may be a potential target. Salidroside (Sal) has good anti-inflammatory effects; however, it remains unclear whether Sal can regulate NLRP3 activation through the Toll-like 4 (TLR4)/nuclear factor kappa B (NF-κB) signaling pathway after to alleviate injury.We established oxygen-glucose...
Anterior compartment prolapse is a common pelvic organ (POP), which occurs frequently among middle-aged and elderly women can cause urinary incontinence, perineal pain swelling, seriously affect their physical mental health. At present, floor ultrasound the primary examination method, but it not carried out by many medical institutions due to significant shortcomings of training in early stage variable image quality. There has been great progress application deep learning (DL) image-based...
Lipid–MMC in cooperation with pegylated lipid–MTX based on PEG–PE–PLA hybrid NPs can coordinate an early-phase targeting effect a late-phase anticancer effect.
The aim of this research was to formulate a liposomal preparation DOX be applied topically, and investigate the in vitro vivo performance prepared liposomes. liposomes were by solvent evaporation method, then modified with bioadhesive material HA. Through MTT assay, we found that safe concentration delivered would hit 1 mg/mL. Cellular uptake studies showed coated HA are much more targetable cell nucleus. Their ocular pharmacokinetics rabbits investigated through comparison those obtained...
Mitomycin C is one of the most effective chemotherapeutic agents for a wide spectrum cancers, but its clinical use still hindered by mitomycin (MMC) delivery systems. In this study, MMC-loaded polymer-lipid hybrid nanoparticles (NPs) were prepared single-step assembly (ACS Nano 2012, 6:4955 to 4965) MMC-soybean phosphatidyhlcholine (SPC) complex (Mol. Pharmaceutics 2013, 10:90 101) and biodegradable polylactic acid (PLA) polymers intravenous MMC delivery. The advantage MMC-SPC on NPs was...
The particle shape of the drug delivery systems had a strong impact on their in vitro and vivo performance, but there was limited availability techniques to produce specific shaped carriers. In this article, novel methotrexate (MTX) decorated MPEG-PLA nanobacillus (MPEG-PLA-MTX NB) prepared by self-assembly technique followed extrusion through SPG membrane with high N2 pressure for targeted delivery, which Janus-like MTX not only used as anticancer could also be served tumor-targeting...
Abstract Recently, methotrexate (MTX) has been used to target folate (FA) receptor-overexpressing cancer cells for targeted drug delivery. However, the systematic evaluation of MTX as a Janus-like agent not reported before. Here, we explored validity using playing an early-phase cancer-specific targeting ligand cooperated with late-phase therapeutic anticancer based on PEGylated chitosan (CS) nanoparticles (NPs) carriers. Some advantages these nanoscaled delivery systems are follows: (1) NPs...
The imbalance of regulatory T cells (Tregs) and helper 17 (Th17) contributes to the persistent hepatitis C virus (HCV) infection. However, modulatory factors associated with Tregs–Th17 balance were not fully elucidated. A recent study demonstrated an immunoregulatory strategy by inactivation Notch signaling reverse disequilibrium in immune thrombocytopenia. Thus, aim this was assess effect regulating functions Tregs Th17 chronic C. total 46 patients normal controls (NCs) enrolled. mRNA...
Carboxymethyl chitin was synthesized through a “green” and homogeneous way in NaOH–urea solvent. Reversible sol–gel transition of carboxymethyl hydrogel can be realized by an electrochemical method.
Poor drug distribution and inefficient concentrations within the tumor intracellular environment still limit therapeutic efficacy of drugs for cancer chemotherapy. Local delivery (physical targeting) combined with receptor-mediated (chemical assistance by a novel shape design is promising strategy to treat infiltrating (even those that persist post surgery). In this paper, we prepared dye methotrexate (MTX) functionalized nanobacilli (MPEG-PLA-MTX-Cy5.5 NB) self-assembly technique extrusion...
The aim of this study was to investigate the therapeutic effect growth differentiation factor 5 (GDF-5) on traumatic brain injury (TBI) in mice. We utilized a controlled cortical impact establish mouse TBI model, and then stereotaxically administered 25 or 100 ng GDF-5 into bilateral hippocampal dentate gyrus (DG) each animals. Seven days after injury, some animals were sacrificed for immunohistochemical immunofluorescence examination 5-bromo-2'-deoxyuridine (BrdU), Sox-2, doublecortin (DCX)...
AIMTo investigate the functional role and underlying molecular mechanism of miR-29a in hepatitis B virus (HBV) expression replication. METHODSThe levels SMARCE1 HBV-infected HepG2.2.15 cells were measured by quantitative real-time PCR western blot analysis.HBV DNA replication was Southern analysis.The relative surface antigen e detected enzyme-linked immunosorbent assay.The Cell Counting Kit-8 (CCK-8) used to detect viability cells.The relationship between identified target prediction...