A5103039229- Pancreatic function and diabetes
- 3D Printing in Biomedical Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Plant Genetic and Mutation Studies
- Pituitary Gland Disorders and Treatments
- Immune cells in cancer
- Ferroptosis and cancer prognosis
- Growth Hormone and Insulin-like Growth Factors
- Pelvic and Acetabular Injuries
- Cancer Immunotherapy and Biomarkers
- Liver physiology and pathology
- Advances in Cucurbitaceae Research
- Urological Disorders and Treatments
- Lipid metabolism and biosynthesis
- Moyamoya disease diagnosis and treatment
- Pleistocene-Era Hominins and Archaeology
- Autoimmune Neurological Disorders and Treatments
- Metabolomics and Mass Spectrometry Studies
- Lipid metabolism and disorders
- Pharmacology and Obesity Treatment
- Cocoa and Sweet Potato Agronomy
- Genomics and Phylogenetic Studies
- Phytoestrogen effects and research
- Vitamin K Research Studies
- Heme Oxygenase-1 and Carbon Monoxide
Tianjin Institute of Pharmaceutical Research (China)
2020-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2022-2024
Capital Medical University
2022-2023
Beijing Obstetrics and Gynecology Hospital
2023
National Clinical Research Center for Digestive Diseases
2022
Beijing Tian Tan Hospital
2022
Sichuan University
2021
Chinese People's Liberation Army
2020-2021
Wake Forest University
2014-2019
First Affiliated Hospital of Henan University of Science and Technology
2014-2018
The metabolic conversion of dietary omega-3 and omega-6 18 carbon (18C) to long chain (>20 carbon) polyunsaturated fatty acids (LC-PUFAs) is vital for human life. rate-limiting steps this process are catalyzed by acid desaturase (FADS) 1 2. Therefore, understanding the evolutionary history FADS genes essential our hominin evolution. have two haplogroups, ancestral derived, with derived haplogroup being associated more efficient LC-PUFA biosynthesis than haplogroup. In addition, there a...
BACKGROUND In vitro and experimental animal studies have demonstrated that high levels of omega-6 (n-6) polyunsaturated fatty acids (PUFAs) ratios n-6 to omega-3 (n-3) PUFAs are strongly associated with the development progression prostate cancer (PCA). However, epidemiological in humans inconsistent findings linking dietary PCA risk. We hypothesize genetic epigenetic variations within acid desaturase (FADS) gene cluster produce gene–diet interactions may explain these disparate findings....
The aim of this study was to investigate the therapeutic effect growth differentiation factor 5 (GDF-5) on traumatic brain injury (TBI) in mice. We utilized a controlled cortical impact establish mouse TBI model, and then stereotaxically administered 25 or 100 ng GDF-5 into bilateral hippocampal dentate gyrus (DG) each animals. Seven days after injury, some animals were sacrificed for immunohistochemical immunofluorescence examination 5-bromo-2'-deoxyuridine (BrdU), Sox-2, doublecortin (DCX)...
Background: The rapid development of immunotherapy has significantly improved patient outcomes in recent years. CD93, a novel biomarker expressed on vascular endothelial cells, is essential for tumor angiogenesis. Recent studies have shown that CD93 closely related to immune cell infiltration and immunotherapy. However, its role pan-cancer not been reported. Methods: Cancer Genome Atlas (TCGA), Human Protein (HPA), cbioportal, Gene Expression Omnibus (GEO), Tumor Immune Estimation Resource...
The relationship between the tumor microenvironment and network of key signaling pathways in cancer plays a role occurrence development tumors. Tumor-associated macrophages (TAMs) are important inflammatory cells play an tumorigenesis progression. Macrophages malignant tumors, mainly M2 subtype, promote progression by producing cytokines down-regulating anti-inflammatory immune responses. Several articles have investigated effect on sensitivity chemotherapeutic agents, but few such been...
Abstract Carbon ion beam is an advanced physical mutagen that used for mutation breeding and functional genomics research. Using carbon beams, a stable Lotus japonicus mutant C16 which showed yellow leaves reduced height compared with the laboratory wild type was obtained in our previous study. Yellow‐leaf desirable characteristic studying photosynthesis. The photosynthetic‐related physiological indexes, including content of chlorophylls ratio variable fluorescence ( F v ) over maximum value...
Pelvic organ prolapse (POP) is the most common and widespread type of female pelvic floor dysfunction disease (PFD). At present, diagnosis POP mainly based on a complicated systematic evaluation clinical phenotype, medical history, relevant functional examinations. Rapid simple tests that are biochemical biomarkers surpass sensitivity specificity current methods for will greatly facilitate timely treatment women with POP.A protein array was used to screen plasma samples collected from...
As a novel long-acting recombinant human insulin analogue, it is necessary to carry out the preclinical research for LysArg. The purpose of this study was characterise pharmacokinetic, tissue distribution and excretion LysArg provide reference its development.Three methods were used measure content in biological samples after single subcutaneous administration rats, including radioassay, radioassay precipitation with TCA separation by HPLC.After Subcutaneous 1, 2, 4 U/kg showed both Cmax...
Objective: To investigate the expression change of Mas1 receptor in placenta healthy pregnant women during different gestation periods, analyze level pre-eclampsia (PE) patients, and its biological function trophoblast cells. Methods: Placental villous tissues were collected from normal early, mid late pregnancy. Human stem cells isolated cultured early pregnancy tissues. The was detected by fluorescence immunoassay real-time quantitative PCR. In a case-control study, patients with full-term...