A5103055601- Epigenetics and DNA Methylation
- RNA modifications and cancer
- interferon and immune responses
- Cancer-related gene regulation
- Environmental Toxicology and Ecotoxicology
- Cancer-related molecular mechanisms research
- Viral Infections and Immunology Research
- Phytoplasmas and Hemiptera pathogens
- CRISPR and Genetic Engineering
- Plant Reproductive Biology
- Bone Metabolism and Diseases
- Acute Myocardial Infarction Research
- Pneumocystis jirovecii pneumonia detection and treatment
- Sleep and related disorders
- Endoplasmic Reticulum Stress and Disease
- Liver physiology and pathology
- Wnt/β-catenin signaling in development and cancer
- HIV/AIDS drug development and treatment
- Proteoglycans and glycosaminoglycans research
- Maternal Mental Health During Pregnancy and Postpartum
- Metabolomics and Mass Spectrometry Studies
- Chromatin Remodeling and Cancer
- RNA and protein synthesis mechanisms
- Neurobiology and Insect Physiology Research
- Angiogenesis and VEGF in Cancer
Xinjiang Medical University
2017-2024
Pearson (United States)
2024
First Affiliated Hospital of Xinjiang Medical University
2017-2024
Chinese Academy of Agricultural Sciences
2023
Institute of Plant Protection
2023
Shenyang Agricultural University
2023
Tianjin Medical University
2019-2022
Tianjin Medical University General Hospital
2022
Tianjin Institute of Pharmaceutical Research (China)
2018-2022
Tianjin University of Traditional Chinese Medicine
2020-2021
Taxifolin is a natural flavonoid compound that can be isolated from onions, grapes, oranges and grapefruit. It also acts as medicine food homology with extraordinary antioxidant anti-inflammatory activity. This study aims to explain the protective effects potential mechanisms of taxifolin against inflammatory reaction.Levels interleukin (IL)-6, IL-1β intracellular reactive oxygen species (ROS) were assessed in different time after treatment RAW264.7 cells induced by lipopolysaccharide (LPS)....
Background:The simplified thrombo-inflammatory score (sTIPS) has recently emerged as a novel prognostic score.Hence, we investigated the value of sTIPS for predicting long-term mortality in patients with heart failure (HF).Methods: A total 3741 were analyzed this study.The was calculated based on white blood cell count (WBC) and mean platelet volume to (MPV/PC) ratio at admission.The follow-up time 22.75 months.Multivariable Cox regression analyses used investigate associations between...
Abstract Polycomb group proteins are often dysregulated in cancer, leading to disruption of epigenetic landscapes and acquisition cancer hallmarks. Chromobox 8 (CBX8) is a core component canonical polycomb repressive complex 1; however, its role transcriptional regulation ovarian carcinoma progression has not been extensively investigated. In this study, we find that CBX8 upregulated cancer. Overexpression knockdown approaches show facilitates the growth migration CAOV3, A2780, SKOV3 cells...
Liver fibrosis is a worldwide problem with significant morbidity and mortality. Cryptolepis sanguinolenta (family Periplocaceae) widely used in West African countries for the treatment of malaria, as well some other diseases. However, role C. hepatic still unknown. It has been reported that Methyl-CpG binding protein 2 (MeCP2) had high expression liver played central its pathobiology. Interestingly, we found cryptolepine derivative (HZ-6h) could inhibit by reducing MeCP2 expression,...
For insects, odorant-binding proteins (OBPs) play an essential role in binding and transporting semiochemicals through the sensillum lymph to olfactory receptor neurons within antennal sensilla. In present study, full-length cDNA encoding a general protein 1 (DcitOBP1, accession number KY475564) was cloned from antennae of Diaphorina citri using RACE-PCR, qRT-PCR analysis revealed that DcitOBP1 gene expressed mainly D. citri. molecular docking assay, results showed has better affinities 12...
Silicon occupies an important position in the nutrient requirements of wheat. It has been reported that silicon enhances plant resistance to phytophagous insects. However, only limited research carried out on effects application wheat and Sitobion avenae populations. In this study, three fertilizer concentrations were treated for potted seedlings, including 0 g/L, 1 2 g/L water-soluble solution. The effect developmental period, longevity, reproduction, wing pattern differentiation, other...
Abstract The Asian citrus psyllid (ACP), Diaphorina citri Kuwayama (Hemiptera:Psyllidae), is one of the most important pests plants worldwide, due to be dominant vector devastating disease Huanglongbing (HLB). Selection suitable oviposition site a crucial event phytophagous insect life. Usually, chemical and physical characteristics host plant were recognized by sensilla on ovipositor tarsi after settling surface. In this study, morphology, number, distribution pattern ovipositorial tarsal...
Astilbin is a dihydroflavonol natural product isolated from variety of food and medicinal herbs (e.g. Smilax glabra Roxb.), its mechanism action in vascular pharmacology remains unclear. The aim this study was to investigate the pro-angiogenic effects astilbin putative action. Briefly, our vitro studies showed dose-dependent ability increase HUVECs proliferate migrate, undergo cell invasion tube formation. Moreover, significantly increased expression levels several major proteins involved...
Abstract As one of the fibroblast growth factor (FGF) superfamily, FGF‐21 has been extensively investigated for its functions and roles since discovery. It demonstrated to be key regulators glucose lipid metabolism, exhibits beneficial effects on cardiovascular disease. However, studies focusing pharmacokinetic behavior in vivo as a novel therapeutic agent have not reported. In present study, rapid sensitive analytical approaches including radioactivity assay after precipitation/separation...
This paper aims to explain the mechanism of Type 1 hypersensitivity and corresponding action loratadine sodium cromoglycate. is most common type allergy, which caused by mast cells leukocytes releasing chemical mediators, including histamines, cytokines, etc. Chemical mediators cause inflammatory responses, as well bind receptors that generate symptoms allergies. Coping with reaction, a antihistamine can inhibit activation H1 receptor it drug performs inverse agonism. Whereas, cromoglycate...
Abstract The E3 ligase TRIM7 has emerged as a critical player in viral infection and pathogenesis. A recent study found that inhibits human enteroviruses through ubiquitination proteasomal degradation of 2BC protein by targeting the 2C moiety protein. Here, we report crystal structures complex with 2C, where C-terminal region is inserted into positively charged groove PRY-SPRY domain. Structure-guided biochemical studies revealed C-terminus glutamine residue primary determinant for binding....
As a novel long-acting recombinant human insulin analogue, it is necessary to carry out the preclinical research for LysArg. The purpose of this study was characterise pharmacokinetic, tissue distribution and excretion LysArg provide reference its development.Three methods were used measure content in biological samples after single subcutaneous administration rats, including radioassay, radioassay precipitation with TCA separation by HPLC.After Subcutaneous 1, 2, 4 U/kg showed both Cmax...
Supplementary Data from CBX8 Together with SET Facilitates Ovarian Carcinoma Growth and Metastasis by Suppressing the Transcription of <i>SUSD2</i>
Supplementary Data from CBX8 Together with SET Facilitates Ovarian Carcinoma Growth and Metastasis by Suppressing the Transcription of <i>SUSD2</i>
<div>Abstract<p>Polycomb group proteins are often dysregulated in cancer, leading to disruption of epigenetic landscapes and acquisition cancer hallmarks. Chromobox 8 (CBX8) is a core component canonical polycomb repressive complex 1; however, its role transcriptional regulation ovarian carcinoma progression has not been extensively investigated. In this study, we find that CBX8 upregulated cancer. Overexpression knockdown approaches show facilitates the growth migration CAOV3,...
<div>Abstract<p>Polycomb group proteins are often dysregulated in cancer, leading to disruption of epigenetic landscapes and acquisition cancer hallmarks. Chromobox 8 (CBX8) is a core component canonical polycomb repressive complex 1; however, its role transcriptional regulation ovarian carcinoma progression has not been extensively investigated. In this study, we find that CBX8 upregulated cancer. Overexpression knockdown approaches show facilitates the growth migration CAOV3,...
Research Purpose: Effects on the altitude training to serum level. There is rare study skaters, and no consistency either, neither there changes of level who were trained altitude, plain alternately. The purpose research observe changeable regularity catabolism top skaters during probe into effects hormone metabolize skaters. author also will provide reference basic with scientific methods. Methods: Subject. Tracing 12 male land as training, contrast groups. subject including 10 master...