A5068547661- interferon and immune responses
- Robotics and Sensor-Based Localization
- Viral gastroenteritis research and epidemiology
- Animal Virus Infections Studies
- Virus-based gene therapy research
- Robotic Path Planning Algorithms
- RNA modifications and cancer
- 3D Surveying and Cultural Heritage
- Influenza Virus Research Studies
- Immune Cell Function and Interaction
- Remote Sensing and LiDAR Applications
- Advanced Fluorescence Microscopy Techniques
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Ubiquitin and proteasome pathways
- Kruppel-like factors research
- Autonomous Vehicle Technology and Safety
- RNA Research and Splicing
- Optical Coherence Tomography Applications
- Animal Disease Management and Epidemiology
- Geotechnical Engineering and Analysis
- Industrial Vision Systems and Defect Detection
- Eosinophilic Disorders and Syndromes
- Chromatin Remodeling and Cancer
- Ferroptosis and cancer prognosis
- Advanced Algorithms and Applications
Tianjin University
2022-2025
Shanghai Jiao Tong University
2021-2024
University of Cambridge
2024
Tianjin Medical University
2017-2024
Beijing University of Chinese Medicine
2023-2024
Southwest Jiaotong University
2022-2023
South China Agricultural University
2022
Institute of Zoology
2016
Chinese Academy of Sciences
2015-2016
OpenStreetMap (OSM) is a low-cost promising alternative to provide the environment representation with global consistency when pre-built LiDAR maps are not available. However, existing descriptor-based perception-OSM matching methods suffered from significant disparities in dimension and precision compared perception map, leading degradation of accuracy. To improve accuracy robustness matching-based position initialization using OSM, this paper proposes novel boundary-relative orientation...
Stimulator of interferon genes (STING, also known as MITA and ERIS) is critical in protecting the host against DNA pathogen invasion. However, molecular mechanism underlying regulation STING remains unclear. Here, we show that PPM1A negatively regulates antiviral signaling by targeting its phosphatase activity-dependent manner, a line with this, catalytically dephosphorylates TBK1 vitro. Importantly, provide evidence whereas promotes aggregation phosphorylation-dependent antagonizes...
Porcine reproductive and respiratory syndrome virus (PRRSV) is a major economically devastating pathogen that has evolved various strategies to evade innate immunity. Downregulation of antiviral interferon largely contributes PRRSV immunoevasion through cytoplasmic melanoma differentiation-associated gene 5 (MDA5), receptor senses viral RNA. In this study, the downregulated transcription expression levels porcine MDA5 in infection were observed, but detailed mechanisms remain unclear. The...
Lung cancer (LC) is the second-highest incidence and first-highest mortality worldwide. Early screening precise treatment of LC have been research hotspots in this field. Artificial intelligence (AI) technology has advantages many aspects widely used such as early diagnosis, differential classification, prognosis prediction. This study aims to analyze visualize history, current status, hotspots, development trends artificial field lung using bibliometric methods, predict future directions...
N(6)-methyladenosine (m
MAVS is a critical adaptor required for activating an innate antiviral immune response against viral infection. The activation of requires modification the Lys63-linked ubiquitination and formation prion-like aggregates. However, molecular mechanisms regulating activity remain largely obscured. In this study, we identified deubiquitinase YOD1, also known as member ovarian tumor family, negative regulator in both human murine cells. YOD1 was recruited to mitochondria interact with through its...
DDAH2 inhibits antiviral signaling by promoting mitochondrial fission.
Abstract Retinoic acid-inducible gene I (RIG-I) plays important roles in pathogen recognition and antiviral signalling transduction. Here we show that syndecan-4 (SDC4) is a RIG-I-interacting partner identified yeast two-hybrid screen. We find SDC4 negatively regulates the RIG-I-mediated feedback-loop control manner. The genetic evidence obtained by using knockout mice further emphasizes this biological role of signalling. Mechanistically, interacts with both RIG-I deubiquitinase CYLD via...
A safe, convenience, and effective vaccine for controlling avian influenza virus infection is crucial in scale poultry production. Yeasts are considered useful vehicles the delivery of antigens, which has been used to protect human animal health. We report here development H9N2 strain hemagglutinin (HA)-based recombinant protein vaccines (rH9HA) DNA-RNA-combined (rH9-DNA-RNA) Saccharomyces cerevisiae first time. The immunogenicity assay indicated that both rH9HA rH9-DNA-RNA could induce...
Apart from the central role of activated JAK/STAT signaling pathway, ASXL1 mutations are most recurrent additional in myeloproliferative neoplasms and occur much more commonly myelofibrosis than essential thrombocythemia polycythemia vera. However, mechanism association with bone marrow fibrosis remains unknown. Here, integrating our own data patients a hematopoietic-specific Asxl1 deletion/Jak2V617F mouse model, we show that associated advanced neoplasm phenotypes onset myelofibrosis....
Abstract The accurate detection and counting of fruits in natural environments are key steps for the early yield estimation orchards realization smart orchard production management. However, existing citrus algorithms have two primary limitations: performance needs to be improved, their system operation efficiency is low practical applications. Therefore, this paper, we propose a novel end‐to‐end fruit pipeline that can used by multiple unmanned aerial vehicles (UAVs) parallel help overcome...
Using fiberglass bolts to reinforce a tunnel face is practical auxiliary technology for ensuring stability in soft ground. The reinforcing effect and the economics of this are significantly affected by bolt length. However, date, failure mechanism bolt-reinforced faces with different lengths has rarely been investigated. To reveal shallow faces, study, was investigated using laboratory tests numerical simulations, simplified theoretical model engineering proposed. support pressure pattern...
Point-scanning microscopy approaches are transforming super-resolution imaging. Despite achieving parallel high-speed imaging using multifocal techniques, efficient multicolor methods with high-quality illumination currently lacking. In this paper, we present for the first time Mechanical-scan-free multiColor Super-resolution Microscopy (MCoSM) spot array illumination, which enables mechanical-scan-free adjustable resolution and a good effective field-of-view based on spatial light...
LEDGF/p75 differentially regulates viral transcription during HIV latency and proviral reactivation.
Apart from the central role of activated JAK/STAT signaling pathway, ASXL1 mutations are most recurrent additional in myeloproliferative neoplasms (MPNs) and occurred much more common myelofibrosis (MF) than essential thrombocythemia (ET) polycythemia vera (PV) patients. However, mechanism association with bone marrow (BM) fibrosis remains unknown. Here, integrating our own data MPN patients hematopoietic-specific Asxl1 deletion/Jak2V617F mouse model, we show that associated advanced...
Hepatocellular carcinoma (HCC) is a frequent primary liver cancer, and it one of the leading cause cancer-related deaths. Hepatitis B virus (HBV) infection crucial risk factor for HCC. Thus, this study aimed to explore prognostic role HBV-positive HCC related specific genes in HCC.The data were downloaded from three databases, including The Cancer Genome Atlas (TCGA), International Consortium (ICGC), Gene Expression Omnibus (GEO). Univariate Cox regression analysis LASSO conducted build Risk...
Porcine reproductive and respiratory syndrome virus (PRRSV) is a serious threat to the global swine industry. As typical immunosuppressive virus, PRRSV has developed variety of complex mechanisms escape host innate immunity. In this study, we uncovered novel immune mechanism infection. Here, demonstrate for first time that endoplasmic reticulum (ER)-resident N-acetyltransferase Nat9 an important restriction factor inhibited proliferation in acetyltransferase activity-dependent manner....
Abstract Cell death-related genes indicate prognosis in cancer patients. PANoptosis is a newly observed form of cell death that researchers have linked to and antitumor immunity. Even so, its significance lung adenocarcinomas (LUADs) has yet be elucidated. We extracted analyzed data on mRNA gene expression clinical information from public databases systematic manner. These were utilized construct reliable risk prediction model for six regulators PANoptosis. The Gene Expression Omnibus (GEO)...