A5101673744- HER2/EGFR in Cancer Research
- Monoclonal and Polyclonal Antibodies Research
- Chemokine receptors and signaling
- Immune cells in cancer
- Viral Infections and Immunology Research
- interferon and immune responses
- Cancer-related Molecular Pathways
- Immune Cell Function and Interaction
- Asymmetric Synthesis and Catalysis
- Chemical Synthesis and Analysis
- Advanced Synthetic Organic Chemistry
- Epigenetics and DNA Methylation
- Immune responses and vaccinations
- Cytokine Signaling Pathways and Interactions
- Fungal Plant Pathogen Control
- Endoplasmic Reticulum Stress and Disease
- Liver physiology and pathology
- Lung Cancer Research Studies
- Power Systems and Technologies
- TGF-β signaling in diseases
- ICT Impact and Policies
- Phosphorus compounds and reactions
- Ubiquitin and proteasome pathways
- Cancer Cells and Metastasis
- Neuropeptides and Animal Physiology
Tianjin Medical University
2018-2022
Pfizer (United States)
2004-2018
Academy of Military Medical Sciences
2007-2009
China Agricultural University
2006-2008
University of Minnesota Medical Center
1996
Bristol-Myers Squibb (United States)
1996
University of Wisconsin–Milwaukee
1994
Abstract Purpose: Anlotinib has achieved good results in clinical trials of a variety cancers. However, the effects anlotinib on tumor microenvironment (TME) and systemic immunity have not been reported. There is an urgent need to identify underlying mechanism reveal new opportunities for its application neuroblastoma (NB) other Understanding will hopefully achieve goal using same method treat different Experimental Design: This study used bioinformatics, NB syngeneic mouse models, flow...
Abstract The proto‐oncogene c‐myc is a key player in cell‐cycle regulation and deregulated broad range of human cancers cell proliferation disorders. Here we reported that overexpression embryonic lung fibroblasts (HEL) have low endogenous enriched S phase cells with increased expression cyclin D3, E, A, Cdk2, Cdk4, decreased p21 p27. To the opposite, using RNAi to downregulate A549 high G1 We found A was most susceptive changes levels essential c‐myc‐modulated cycle pathway via...
C-X-C chemokine receptor type 7 (CXCR7) is involved in cardiac and immune pathophysiology. We report the discovery of a novel 1,4-diazepine CXCR7 modulator, demonstrating for first time role pharmacological intervention repair. Structure-activity-relationship (SAR) studies demonstrated that net reduction lipophilicity (log D) an incorporation saturated ring systems yielded compounds with good potencies improvements oxidative metabolic stability human-liver microsomes (HLM). Tethering...
A process is described for the synthesis of kilogram quantities homochiral 4-silyloxycyclopentenone (R)-1, a key intermediate useful plurality prostaglandin analogue drugs. Cyclopentenone (R)-1 was synthesized in 14 isolated steps from furfural. Key include Wittig reaction, Piancatelli rearrangement, and an enzymatic resolution featuring situ recycling undesired enantiomer furnishing desired alcohol ≥99.5% ee. As retort to unsatisfactory coformation about 8% at best trans-olefin change order...
The aim of this study was to investigate the monitoring value serum HER2 in patients with metastatic breast cancer.We firstly evaluated association levels tissue expression and imaging results 420 cancer admitted into Tianjin Medical University Cancer Institute Hospital between April 2016 December 2018. Secondly, we analyzed different degrees.There is a higher correlation stage III (κ=0.670, p<0.001) IV (κ=0.464, p<0.001). Serum were significantly associated (κ=0.478, ROC curve analysis...
Follistatin (FST), an activin-binding protein, inhibits activin action by interfering with binding to its receptor. The prognostic value of FST has been studied in various cancers. However, these studies rarely focus on lung cancer. In our study, we investigated the relationship between serum levels and cancer histologic types, TNM staging, recurrence.A total 150 samples were collected, including 91 from patients SCLC or NSCLC, 22 benign diseases, 37 healthy subjects. Enzyme-linked...
Objective: Trained immunity of natural killer (NK) cells has shown great potential in the treatment cancers by eliciting enhanced effector responses to restimulation cytokines or cancer for long time periods after preactivation. However, human NK responsible generation and maintenance trained are largely unknown. We hypothesized that heterogeneous would respond differentially stimulation with a combination IL-12, IL-15, IL-18, an cell subset might exist is mainly induction immunity. On basis...
Here we provide experimental evidence that ionizing radiation induces inhibitory tyrosine phosphorylation of the p34cdc2 kinase in human leukemic B-cell precursors. Herbimycin A markedly reduced irradiated precursors, thereby preventing radiation-induced cell cycle arrest at G2-M transition checkpoint. Thus, is directly responsible for inactivation precursors and activation protein kinases a proximal mandatory step G2-arrest Human WEE1 isolated from unirradiated or had minimal activity...
Abstract The E3 ligase TRIM7 has emerged as a critical player in viral infection and pathogenesis. A recent study found that inhibits human enteroviruses through ubiquitination proteasomal degradation of 2BC protein by targeting the 2C moiety protein. Here, we report crystal structures complex with 2C, where C-terminal region is inserted into positively charged groove PRY-SPRY domain. Structure-guided biochemical studies revealed C-terminus glutamine residue primary determinant for binding....
Auranofin [Et3PAuSATg =triethylphosphine-(2,3,4,6-tetra-O-acetyl-l-thio-8-D-glucopyranosato-S)- gold(I)] is an antiarthritic drug.Its metabolism Includes two Iigand displacements at gold(I).A reversible displacement of the thiol ligand drug by Cys-34 residue serum albumin observed as a first step in vitro reactions and albumin.This feature may facilitate gold(I) transfer from site to vivo.To investigate rate this exchange, 31 p NMR saturation study was performed.In order minimize side reaction which
Objective To investigate the regulatory effects of CD24 on Ly6Chi macrophages in liver and its influences bile duct ligation (BDL)-induced hepatic fibrosis mice. Methods Liver was induced wild-type (WT) CD24-/- mice by surgical biliary duct. Levels alanine amino transferase (ALT) serum were detected sections stained with haematoxylin eosin (H&E) staining to assess severity injury. Sirius Red used observe degree fibrosis. Real-time PCR performed for detecting expression...