A5004962384- Catalytic C–H Functionalization Methods
- Welding Techniques and Residual Stresses
- Receptor Mechanisms and Signaling
- Non-Destructive Testing Techniques
- Cyclopropane Reaction Mechanisms
- Robot Manipulation and Learning
- Synthesis and Catalytic Reactions
- Asymmetric Hydrogenation and Catalysis
- Catalytic Cross-Coupling Reactions
- Asymmetric Synthesis and Catalysis
- Neuropeptides and Animal Physiology
- Radical Photochemical Reactions
- Chemical Synthesis and Analysis
- Teleoperation and Haptic Systems
- Synthetic Organic Chemistry Methods
- Advanced machining processes and optimization
- Synthesis and biological activity
- Catalytic Alkyne Reactions
- Click Chemistry and Applications
- Sulfur-Based Synthesis Techniques
- Multicomponent Synthesis of Heterocycles
- Thermography and Photoacoustic Techniques
- Oxidative Organic Chemistry Reactions
- Synthesis and Biological Evaluation
- Industrial Vision Systems and Defect Detection
Nanjing Tech University
2022-2024
University of Cambridge
2024
Pfizer (United States)
2006-2023
University of Kentucky
2019-2020
North China University of Water Resources and Electric Power
2019
Foton Motors (China)
2012
Illinois State University
2003
This paper presents an innovative investigation on prototyping a digital twin (DT) as the platform for human-robot interactive welding and welder behavior analysis. interaction (HRI) working style helps to enhance human users' operational productivity comfort; while data-driven analysis benefits further novice training. HRI system includes three modules: 1) user who demonstrates operations offsite with her/his recorded by motion-tracked handles; 2) robot that executes demonstrated complete...
The medicinal chemistry and preclinical biology of imidazopyridine-based inhibitors diacylglycerol acyltransferase 2 (DGAT2) is described. A screening hit 1 with low lipophilic efficiency (LipE) was optimized through two key structural modifications: (1) identification the pyrrolidine amide group for a significant LipE improvement, (2) insertion sp(3)-hybridized carbon center in core molecule simultaneous improvement N-glucuronidation metabolic liability off-target pharmacology. candidate 9...
Myeloperoxidase (MPO) is a heme peroxidase that catalyzes the production of hypochlorous acid. Clinical evidence suggests causal role for MPO in various autoimmune and inflammatory disorders including vasculitis cardiovascular Parkinson's diseases, implying inhibitors may represent therapeutic treatment option. Herein, we present design, synthesis, preclinical evaluation N1-substituted-6-arylthiouracils as potent selective MPO. Inhibition proceeded time-dependent manner by covalent,...
We propose an innovative approach to enhance welding operations by using a cyber-physical system (CPS) with layered architecture and enabling robot be effectively operated its commanding human. This article focuses on the recognition of human's intention that should executed robot. To this end, virtual reality (VR) based HTC Vive is used create remote environment. Human hand movement speed data collected train hidden Markov model (HMM) Baum-Welch algorithm. The Bayesian information criterion...
A method to assemble (hetero)aryl sulfonamides via the reductive coupling of aryl sulfinates and nitroarenes is reported. Various reducing conditions with sodium bisulfite or without tin(II) chloride in DMSO were developed using an ultrasound bath improve reaction homogeneity mixing. range bearing a selection functional groups prepared, mechanism transformation was investigated. These investigations have led us propose formation nitrosoarene intermediates, which established independent...
Identifying the parameters of solar photovoltaic (PV) cell models accurately and reliably is crucial for simulating, evaluating, controlling PV systems. For this reason, we present an improved chimp optimization algorithm (IChOA) generation precise reliable models. As a new version standard (ChOA), IChOA embeds two mutation rules in ChOA that include elite opposition-based learning visual search mechanism. The first rule applied to strengthen global exploration capacity ChOA, second one...
Takeda G-protein-coupled receptor 5 (TGR5) represents an exciting biological target for the potential treatment of diabetes and metabolic syndrome. A new class high-throughput screening (HTS)-derived tetrahydropyrido[4,3-d]pyrimidine amide TGR5 agonists is disclosed. We describe our effort to identify orally available agonist suitable assessment systemic agonism. This resulted in identification 16, which had acceptable potency pharmacokinetic properties allow vivo dog. key aspect this work...
A diastereoselective, Pd-catalyzed Suzuki–Miyaura coupling reaction of geminal bis(boryl)cyclopropanes has been developed. The offers a highly modular approach to the synthesis tertiary cyclopropylboronic esters. resulting boronic esters may be further functionalized afford range gem-disubstituted cyclopropanes, which represent an important structural motif in pharmaceutical industry. Sequential cross-coupling reactions gem-bis(boryl)cyclopropanes are also reported. protocols compatible with...
An innovative method was proposed to determine weld joint penetration using machine learning techniques. In our approach, the dot-structured laser images reflected from an oscillating pool surface were captured. Experienced welders typically evaluate status based on this pattern. To overcome challenges in identifying features and accurately processing conventional vision algorithms, we use raw without any as input a convolutional neural network (CNN). The labels needed train CNN measured...
Recent studies in adipose tissue, pancreas, muscle, and macrophages suggest that MAP4K4, a serine/threonine protein kinase may be viable target for antidiabetic drugs. As part of the evaluation MAP4K4 as novel target, tool compound, 16 (PF-6260933) lead 17 possessing excellent kinome selectivity suitable properties were delivered to establish proof concept vivo. The medicinal chemistry effort led discovery these compounds is described herein together with vivo pharmacokinetic activity model...
This letter presents a virtual reality (VR) human–robot interaction welding system that allows human welders to manipulate robot and undertake tasks naturally intuitively via consumer-grade VR hardware (HTC Vive). In this system, welders' operations are captured by motion-tracked handle controllers used as commands teleoperate 6-DoF industrial (UR-5) request current from controllable power supply (Liburdi Pulsweld P200). The three-dimensional (3-D) working scene is rendered in real time...
With the challenge of striking balance TGR5 potency and clearance, screening strategy as well medicinal chemistry are discussed in this article.
C-X-C chemokine receptor type 7 (CXCR7) is involved in cardiac and immune pathophysiology. We report the discovery of a novel 1,4-diazepine CXCR7 modulator, demonstrating for first time role pharmacological intervention repair. Structure-activity-relationship (SAR) studies demonstrated that net reduction lipophilicity (log D) an incorporation saturated ring systems yielded compounds with good potencies improvements oxidative metabolic stability human-liver microsomes (HLM). Tethering...
A method for the modular synthesis of α-heteroaryl piperidines is reported. The two-step procedure consists an initial Pd-catalyzed Suzuki cross-coupling heteroaryl bromide with a boronate ester derived from N-Boc piperidone, followed by subsequent tetrahydropyridine reduction. Using this method, piperidine products featuring broad range pharmaceutically relevant azine and diazine substitutions have been prepared.
While penetration occurs underneath the workpiece, raw information used to detect it during welding must be measurable a sensor attached torch. Challenges are apparent because is difficult find such that fundamentally correlates with phenomena occurring underneath. Additional challenges arise process extremely complex analytically correlating any practically impossible; therefore, handcrafted methods propose features from human dependent and labor extensive. In this paper, profile of weld...