A5100383211- Antibiotic Resistance in Bacteria
- Hearing, Cochlea, Tinnitus, Genetics
- Bacteriophages and microbial interactions
- Sleep and Wakefulness Research
- Regulation of Appetite and Obesity
- Circadian rhythm and melatonin
- Bacterial biofilms and quorum sensing
- Aortic aneurysm repair treatments
- RNA modifications and cancer
- Microbial infections and disease research
- RNA Research and Splicing
- Advanced Sensor and Energy Harvesting Materials
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Retinal Development and Disorders
- Cancer-related molecular mechanisms research
- Immune Cell Function and Interaction
- Cancer-related gene regulation
- Biochemical Analysis and Sensing Techniques
- Hearing Loss and Rehabilitation
- Inflammatory mediators and NSAID effects
- Enterobacteriaceae and Cronobacter Research
- Infections and bacterial resistance
- Immune Response and Inflammation
- Interactive and Immersive Displays
- Plant Gene Expression Analysis
North China Electric Power University
2025
Peking University
2012-2024
Yangzhou University
2021-2024
Jiangsu Provincial Center for Disease Control and Prevention
2024
Zhejiang A & F University
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
Tianjin Medical University
2024
Shandong First Medical University
2022-2023
Purdue University West Lafayette
2020-2023
Institute of Animal Science
2023
Progressive functional deterioration in the cochlea is associated with age-related hearing loss (ARHL). However, cellular and molecular basis underlying cochlear aging remains largely unknown. Here, we established a dynamic single-cell transcriptomic landscape of mouse aging, which characterized aging-associated changes 27 different cell types across five time points. Overall, our analysis pinpoints proteostasis elevated apoptosis as hallmark features highlights unexpected transcriptional...
Abdominal aortic aneurysm (AAA) is a lethal cardiovascular disease, and there no proven drug treatment for this condition. In study, by using the Connectivity Map (CMap) approach, we explored naringenin, naturally occurring citrus flavonoid, as putative agent inhibiting AAA. We then validated prediction with two independent mouse models of AAA, calcium phosphate (CaPO4)-induced C57BL/6J mice angiotensin II-infused ApoE-/- mice. Naringenin effectively blocked formation AAAs progression...
Cytotoxic T lymphocyte antigen 4 (CTLA4) exerts inhibitory effects on T-cell activation by competition with CD28. In this study, we investigated the effect of CTLA4-IgG homocysteine (Hcy)-induced and potential signal pathways involved in atherosclerotic formation. The CD28 was significantly amplified Hcy treatment splenic cells hyperhomocysteinaemia (HHcy)-accelerated plaques apolipoprotein E-deficient (apoE–/–) mice. As a major competitor CD28, (abatacept) pretreatment, 100 μg/week, apoE–/–...
In visceral obesity, an overactive endocannabinoid/CB1 receptor (CB1R) system promotes increased caloric intake and decreases energy expenditure, which are mitigated by global or peripheral CB1R blockade. mice with diet-induced obesity (DIO), inhibition of food the peripherally restricted antagonist JD5037 could be attributed to endogenous leptin due rapid reversal hyperleptinemia that maintains resistance, but signaling pathway engaged has remained determined. We analyzed hypothalamic...
Compelling evidence has revealed that biased activation of G protein-coupled receptor (GPCR) signaling, including angiotensin II (AngII) type 1 (AT1) plays pivotal roles in vascular homeostasis and injury, but whether a clinically relevant endogenous antagonism AT1 signaling exists under physiological pathophysiological conditions not been clearly elucidated. Here, we show an extracellular matrix protein, cartilage oligomeric protein (COMP), acts as allosteric modulator the its deficiency is...
Abstract Large cointegrate plasmids recruit genetic features of their parental and serve as important vectors in the spread antibiotic resistance. They are now frequently found clinical settings, raising issue how to limit further transmission. Here, we conducted evolutionary research a large blaNDM-positive within Escherichia coli C600, discovered that adaptive evolution chromosome plasmid jointly improved bacterial fitness, which was manifested enhanced survival ability for vivo vitro...
N(6)-methyladenosine (m
Abstract The safety risks associated with hydrogen production plants are significant and warrant close attention. Investigating the effects of vault structures on dispersion leaked can inform assessments how facility influence behavior, providing a theoretical framework for secure layout plants. CFD software Ansys Fluent was employed in this research to establish model plant. Simulations were conducted assess distribution flammable clouds under various heights. Results indicate that, upon...
Trio is a guanine nucleotide exchange factor with multiple domains. regulates cytoskeleton dynamics and actin remodeling involved in cell migration axonal guidance neuronal development. The null allele of the gene led to embryonic lethality, embryos displayed aberrant organization several regions brain at E18.5, including hippocampus. Nestin-Trio-/- mice, which was deleted specifically system by Nestin-Cre system, severe phenotypes, low survival rate, ataxia developmental defects cerebellum....
Sodium butyrate is the sodium salt of butyric acid, which possesses many biological functions including immune system regulation, anti-oxidant and anti-inflammatory ability. The present study was designed to elucidate effects mechanisms on lipopolysaccharide (LPS)-stimulated bovine macrophages. effect cell viability macrophages assayed by using CCK-8 kit. Quantitative real-time PCR (qRT-PCR) used detect gene expression interleukin-6 (IL-6), interleukin-1β (IL-1β), cyclooxygenase-2 (COX-2),...
Abstract The peroxisome is a ubiquitous organelle in rodent cells and plays important roles variety of cell types tissues. It previously indicated that peroxisomes are associated with auditory function, patients biogenesis disorders (PBDs) found to have hearing dysfunction, but the specific role remains unclear. In this study, two peroxisome‐deficient mouse models ( Atoh1‐Pex5 −/− Pax2‐Pex5 ) established it mainly function hair cochleae. Furthermore, deficiency‐mediated negative effects on...
T-2 toxin (T-2) is a kind of trichothecene produced from Fusarium fungi, which an environmental pollutant that endangers poultry and human health. Heterophil extracellular traps (HETs) are not only form chicken immune defense against pathogen infection but also involved in pathophysiological mechanisms several diseases. However, the immunotoxicity on HET formation vitro has yet been reported. In this study, heterophils were exposed to at doses 20, 40, 80 ng/mL for 90 min. Observation...
Cointegrate/hybrid plasmids combine the genetic elements of two or more and generally carry abundant antimicrobial resistance determinants. Hence, spread cointegrate will accelerate transmission AMR genes. To evaluate risk caused by plasmids, we investigated structural diversity, fitness cost, stability a plasmid in Klebsiella pneumoniae YZ6 Escherichia coli EC600. The pSL131_IncA/C_IncX3 was from clinical Salmonella Lomita strain. After transferring into E. EC600 conjugation, observed with...
The biological toxicity of deltamethrin at molecular level has been investigated, whereas, the proteome responsive mechanisms cells under stress phylogenetic are not clear. expression, transformation-related pathway and regulatory network Bacillus thuringiensis during process transformation were explored using proteomics metabolomics approaches in present study. results showed that was effectively removed by B. within 48 h. responses activated to resist stress, with significant differential...
Generation of hybrid MDR plasmids accelerated the evolution and transmission resistance genes. In this study, we characterized a blaKPC-2- blaIMP-4-coharboring conjugative plasmid constituted an IncHI5 plasmid-like region, IncFII(Yp)/IncFIA KPN1344 chromosome-like region from clinical ST852-KL18 Klebsiella quasipneumoniae strain. The blaIMP-4 gene was captured by novel integron In1965, blaKPC-2 located on new non-Tn4401 group I NTEKPC element. Both blaIMP-4-containing genetic architectures...
Abstract Van der Waals (vdW) integration enables clean contacts for low‐dimensional electronic devices. The limitation remains; however, that an additional tunneling contact resistance occurs owing to the inherent vdW gap between metal and semiconductor. Here, it is demonstrated from theoretical calculations stronger non‐covalent hydrogen‐bonding interactions facilitate electron significantly reduce resistance; thus, promising break limitations of contact. π‐plane in surface‐engineered...
Dyslexia is a reading and spelling disorder due to neurodevelopmental abnormalities occasionally found be accompanied by hearing loss, but the reason for associated deafness remains unclear. This study finds that knockout of dyslexia susceptibility 1 candidate gene (Dyx1c1