A5081758034- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Plant Pathogens and Fungal Diseases
- Diabetes Treatment and Management
- Corneal surgery and disorders
- Ophthalmology and Visual Impairment Studies
- CRISPR and Genetic Engineering
- Neuroendocrine Tumor Research Advances
- Diabetes Management and Research
- Mycotoxins in Agriculture and Food
- Biochemical and Molecular Research
- Neuroblastoma Research and Treatments
- Advanced biosensing and bioanalysis techniques
- Mycorrhizal Fungi and Plant Interactions
- Pancreatic function and diabetes
- Connexins and lens biology
- Gut microbiota and health
- Intraocular Surgery and Lenses
- Noise Effects and Management
- MicroRNA in disease regulation
- Diabetes and associated disorders
- RNA modifications and cancer
- Fungal Biology and Applications
- DNA Repair Mechanisms
- DNA and Nucleic Acid Chemistry
Sichuan Cancer Hospital
2023-2025
Zhejiang Chinese Medical University
2023-2025
Xian Yang Central Hospital
2025
North University of China
2024-2025
Institute of Coal Chemistry
2025
King Abdullah University of Science and Technology
2021-2024
Wuxi Fourth People's Hospital
2013-2024
East China University of Technology
2024
Jiaxing University
2023-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2013-2024
Telotristat ethyl, a tryptophan hydroxylase inhibitor, was efficacious and well tolerated in the phase 3 TELESTAR study patients with carcinoid syndrome (CS) experiencing ≥4 bowel movements per day (BMs/day) while on somatostatin analogs (SSAs). TELECAST, companion study, assessed safety efficacy of telotristat ethyl CS (diarrhea, flushing, abdominal pain, nausea or elevated urinary 5-hydroxyindoleacetic acid (u5-HIAA)) <4 BMs/day SSAs (or ≥1 symptom if not SSAs) during 12-week...
The World Health Organization's global initiative toward eliminating high-risk Human Papillomavirus (hrHPV)-related cancers recommends DNA testing over visual inspection in all settings for primary cancer screening and HPV eradication by 2100. However, multiple hrHPV types cause different of cancers, there is a pressing need an easy-to-use, multiplex point-of-care diagnostic platform detecting types. Recently, CRISPR-Cas systems have been repurposed detection. Here, we established...
Abstract Genome-editing technologies have revolutionized research in plant biology, with major implications for agriculture and worldwide food security, particularly the face of challenges such as climate change increasing human populations. Among these technologies, clustered regularly interspaced short palindromic repeats [CRISPR]–CRISPR-associated protein [Cas] systems are now widely used editing crop genomes. In this review, we provide an overview CRISPR–Cas technology its most...
Diabetes is closely linked to hearing loss, yet the exact mechanisms remain unclear. Cochlear stria vascularis and pericytes (PCs) are crucial for hearing. This study investigates whether high glucose induces apoptosis in cochlear via elevated ROS levels due oxidative stress, impacting loss.
BackgroundEpilepsy is recognized as the most common chronic neurological condition among children, and hippocampal neuronal cell death has been identified a crucial factor in pathophysiological processes underlying seizures. In recent studies, PANoptosis, newly characterized form of death, emerged significant contributor to development various disorders, including Alzheimer's disease, Parkinson's amyotrophic lateral sclerosis. PANoptosis involves simultaneous activation pyroptosis,...
Background: Blood-labyrinth barrier (BLB) damage has been recognized as a key mechanism underlying cisplatin (CDDP)-induced hearing loss.Inflammation within the cochlea, triggered by CDDP, is pathological response.However, relationship between CDDP-induced inflammation and BLB dysfunction remains elusive.Materials Methods: In vivo in vitro models were used to explore inflammatory mechanisms CDDP ototoxicity.C57BL/6J mice treated with IL-1β levels, permeability, thresholds assessed using...
A practical approach is presented for the highly selective hydrogenation of various unsaturated compounds using a cutting-edge Ru/PNN catalytic system, resulting in high turnover numbers and substantial production valuable pharmaceuticals.
To observe the efficacy and safety of eye transcutaneous electrical acupoint stimulation (Eye-TEAS) on preventing progression pre-myopic to myopia in children aged 6-12 years. A total 170 years were randomly divided into an Eye-TEAS group (85 cases, 3 cases dropped out, 2 eliminated) a placebo eliminated). The received intervention at bilateral Cuanzhu (BL2), Yuyao (EX-HN4), Sizhukong (TE23), Taiyang (EX-HN5), Sibai (ST2), Jingming (BL1), with continuous wave frequency 4 Hz current 1-2 mA...
Tumor-associated macrophages (TAMs) play pivotal roles in innate immunity and contribute to the advancement of lung cancer. We aimed identify novel TAM-related biomarkers significance macrophage infiltration adenocarcinoma (LUAD) through an integrative analysis single-cell RNA-sequencing (scRNA-seq) data. To describe cell atlas construct a prognostic signature LUAD. The gene linked TAMs was identified utilizing Scanpy from scRNA-seq dataset GSE131907. Subsequent involved evaluating...
Epimedium L., the largest herbaceous genus of Berberidaceae, is one most taxonomically difficult representatives. The classification and phylogenetic relationships within are controversial unresolved.For first time, we systematically studied phylogeny evolution based on plastid genome (plastome) data for better understanding this enigmatic genus.We explored molecular phylogeny, assessed infrageneric classification, estimated divergence times, inferred ancestral states flower traits 45...
A practical one-pot catalytic tandem multicomponent allylation condensation carbonylation to construct allylhydrazones and allyl acylhydrazones with high atom economy, water as a coproduct excellent regioselectivity in reactions.