A5083861553- Adsorption and Cooling Systems
- Phase Change Materials Research
- Building Energy and Comfort Optimization
- Refrigeration and Air Conditioning Technologies
- Aerosol Filtration and Electrostatic Precipitation
- Solar Thermal and Photovoltaic Systems
- Tryptophan and brain disorders
- MicroRNA in disease regulation
- Heat Transfer and Optimization
- RNA Interference and Gene Delivery
- High voltage insulation and dielectric phenomena
- Mental Health Research Topics
- Infection Control and Ventilation
- Functional Brain Connectivity Studies
- Heat Transfer and Boiling Studies
- Bacillus and Francisella bacterial research
- Electrohydrodynamics and Fluid Dynamics
- Wind and Air Flow Studies
- Food Supply Chain Traceability
- Epigenetics and DNA Methylation
- Advanced biosensing and bioanalysis techniques
- Genetic diversity and population structure
- Bacterial Genetics and Biotechnology
- Lepidoptera: Biology and Taxonomy
- PI3K/AKT/mTOR signaling in cancer
Peking University
2025
Peking University Sixth Hospital
2025
First Affiliated Hospital of Zhengzhou University
2024-2025
Tianjin University of Commerce
2017-2024
National University of Singapore
2022-2024
Shihezi University
2024
Academy of Military Medical Sciences
2013-2024
Guangzhou Center for Disease Control and Prevention
2024
Zhongda Hospital Southeast University
2020-2023
Second Xiangya Hospital of Central South University
2023
Abstract Oxidative stress, chronic inflammation, and immune senescence are important pathologic factors in diabetic wound nonhealing. This study loads taurine (Tau) into cerium dioxide (CeO 2 ) to develop CeO @Tau nanoparticles with excellent antioxidant, anti‐inflammatory, anti‐aging properties. To enhance the drug penetration efficiency wounds, is encapsulated gelatin methacryloyl (GelMA) hydrogel prepare @Tau@Hydrogel@Microneedle (CTH@MN) patch system. Microneedle technology achieves...
In Lepidoptera (butterflies and moths), a genomic region around the gene cortex is hotspot locus, repeatedly used to generate intraspecific melanic wing color polymorphisms across 100-million-years of evolution. However, identity effector regulating within this locus remains unknown. Here, we show that none four candidate protein-coding genes including cortex, serve as major effectors. Instead, micro-RNA (miRNA), mir-193, serves three deeply diverged lineages butterflies, its function...
In RNA interference (RNAi), small interfering (siRNA) suppresses the expression of its target mRNA with a perfect complementary sequence. addition, siRNA also unintended mRNAs partially sequences mainly within seed region (nucleotides 2–8). This mechanism is highly similar to microRNA (miRNA)-mediated silencing, and known as siRNA-mediated off-target effect. Previously, we revealed that effect induced through stable base-pairing between mRNAs, but not unstable base-pairing. However, in our...
Abstract Organisms residing in regions with alternating seasons often develop different phenotypes, or forms, each season. These forms are adaptations to season and result from an altered developmental response specific environmental cues such as temperature. Although multiple studies have examined form-specific gene expression profiles a diversity of species, little is known about how environments transitions, cued by hormone pulses, alter post-transcriptional patterns. In this study, we...
In Lepidoptera (butterflies and moths), the genomic region around gene cortex is a “hotspot” locus, repeatedly implicated in generating intraspecific melanic wing color polymorphisms across 100 million years of evolution. However, identity effector regulating within this locus remains unknown. We show that none four candidate protein-coding genes including , serve as major effectors. Instead, microRNA (miRNA), mir-193 serves three deeply diverged lineages butterflies, its role conserved...
Abstract Background The emotion regulation network (ERN) in the brain provides a framework for understanding neuropathology of affective disorders. Although previous neuroimaging studies have investigated neurobiological correlates ERN major depressive disorder (MDD), whether patients with MDD exhibit abnormal functional connectivity (FC) patterns and FC can serve as therapeutic response signature remain unclear. Methods A large magnetic resonance imaging dataset comprising 709 725 healthy...
Small molecule Menin inhibitor recently has emerged as a new therapeutic by targeting the interaction of histone methyltransferase MLL1 (KMT2A) with Menin. is associated aggressive osteosarcoma (OS) in young adults. The purpose study to explore whether inhibitors have effects OS.To investigate anti-OS activity MI-503 vitro, we performed CCK-8 cell growth and colony formation assay. Cellular thermal shift assay was used test binds cells. expression oncogenes treated cells were detected...
The role of neuroimmune mechanisms in major depressive disorder (MDD) has been gradually highlighted, but existing classical animal models MDD have limitations immune inflammation research due to physical injury, high mortality rates, and tolerance. This study developed a novel mouse model depression called the post-witness social defeat stress (PWSDS) model, which combines witness with paradigm. was evaluated based on behavior, central peripheral responses, predictive validity. findings...
Graphene and its derivatives have exhibited wide potential applications in electronics, structural engineering medicine. However, over utilization untreated discharge may cause distribution into environmental as well biological chain, which raised the concerns of health risk a hazard. Accumulating evidence has demonstrated that graphene induce lung fibrosis vivo, so overall goal this study was to explore molecular mechanisms underlying pulmonary fibrotic responses reduced oxide (rGO), using...
Photosynthesis of Microcystis aeruginosa under Electromagnetic Radiation (1.8 GHz, 40 V/m) was studied by using the proteomics. A total 30 differentially expressed proteins, including 15 up-regulated and down-regulated were obtained in this study. The proteins significantly enriched photosynthesis pathway, which protein expression levels photosystems II cytochrome b559 α subunit, C550, PsbY, F-type ATP synthase (a, b) decreased. Our results indicated that electromagnetic radiation altered...
Spray cooling is effectively utilized in evaporative condensers to achieve efficient heat and mass transfer transmission, while also preventing performance degradation caused by packing blockage. The efficiency strongly affected the relative flow direction between spray air flow. This work employs computational fluid dynamics evaluate examine effects of parallel countercurrent condensers. findings indicate that increasing density wall temperature enhances efficiency. Smaller droplets with...
Cereulide-producing Bacillus cereus isolates can cause serious emetic (vomiting) syndrome and even acute lethality. As mobile genetic elements, the exploration of prophages derived from B. will help in our understanding diversity evolution these pathogens. In this study, five temperate phages cereulide-producing strains were induced, with four them undergoing genomic sequencing. Sequencing revealed that they all belong to Siphoviridae family, but presented different forms their hosts....