A5103089427- Thyroid Cancer Diagnosis and Treatment
- Thyroid Disorders and Treatments
- Glioma Diagnosis and Treatment
- RNA modifications and cancer
- Medical Imaging Techniques and Applications
- Cancer-related gene regulation
- Phagocytosis and Immune Regulation
- Epigenetics and DNA Methylation
- Radiopharmaceutical Chemistry and Applications
- Orthopaedic implants and arthroplasty
- Total Knee Arthroplasty Outcomes
- CRISPR and Genetic Engineering
- Salivary Gland Tumors Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Mechanisms of cancer metastasis
- Ferroptosis and cancer prognosis
- Cancer, Hypoxia, and Metabolism
- Cell Adhesion Molecules Research
- FOXO transcription factor regulation
- Immunotherapy and Immune Responses
- Cancer Cells and Metastasis
- RNA Research and Splicing
- Bone health and treatments
- Cancer Mechanisms and Therapy
- Parkinson's Disease Mechanisms and Treatments
Tianjin Medical University
2006-2024
First Affiliated Hospital of Fujian Medical University
2022-2024
Fujian Medical University
2022-2024
Anhui Polytechnic University
2024
Tianjin Medical University General Hospital
2006-2022
Harbin Medical University
2014-2021
Fourth Affiliated Hospital of Harbin Medical University
2020-2021
Zhejiang University
2020
Second Affiliated Hospital of Xi'an Jiaotong University
2015
Gansu Provincial Hospital
2014
The dynamic changes of RNA N6-methyl-adenosine (m6A) during cancer progression contribute to quick adaption microenvironmental changes. Here, we profiled the cell m6A dynamics in hypoxic tumor niche and its pathological consequences glioblastoma multiforme (GBM). demethylase ALKBH5 was induced GBM models under conditions associated with a gene signature patient samples. Depletion or inactivation cells significantly suppressed hypoxia-induced tumor-associated macrophage (TAM) recruitment...
Transcriptional deregulation has a vital role in glioblastoma multiforme (GBM). Thus, identification of epigenetic modifiers essential for oncogenic transcriptional programs is key to designing effective therapeutics this deadly disease. Here we report that Protein Arginine Methyltransferase 2 (PRMT2) highly expressed GBM and correlated with poor prognosis. The silencing or inactivation PRMT2 inhibits cell growth stem self-renewal vitro, suppresses orthotopic tumor growth, accompanied...
Abstract Amplification of epidermal growth factor receptor (EGFR) and active mutant EGFRvIII occurs frequently in glioblastoma (GBM) contributes to chemo/radio‐resistance various cancers, especially GBM. Elucidating the underlying molecular mechanism temozolomide (TMZ) resistance GBM could benefit cancer patients. A genome‐wide screening under a clustered regularly interspaced short palindromic repeats (CRISPR)‐Cas9 library is conducted identify genes that confer TMZ EGFRvIII‐expressing...
Abstract N 6 ‐methyladenosine (m A) is a novel epitranscriptomic marker that contributes to regulating diverse biological processes through controlling messenger RNA metabolism. However, it unknown if m A methylation affects uveal melanoma (UM) development. To address this question, we probed its function and molecular mechanism in UM. Initially, demonstrated global levels were dramatically elevated both UM cell lines clinical specimens. Meanwhile, found METTL3, main regulatory enzyme, was...
Surface topography dictates important aspects of cell biological behaviors. In our study, hierarchical micro-nano (SLM-AHT) with micro-scale grooves and nano-scale pores was fabricated compared smooth (S) irregular (SLA) surfaces to investigate mechanism involved in cell-surface interactions. Integrin α2 had a higher expression level on SLM-AHT surface S SLA surfaces, the levels osteogenic markers icluding Runx2, Col1a1, Ocn were concomitantly upregulated surface. Moreover, formation mature...
N(6)-methyladenosine (m
Glioblastoma multiforme (GBM) is the most common and aggressive brain tumor refractory to existing therapies. The oncogene BMI-1, a member of Polycomb Repressive Complex 1 (PRC1) plays essential roles in various human cancers becomes an attractive therapeutic target. Here we showed that BMI-1 highly expressed GBM especially enriched glioblastoma stem cells (GSCs). Then comprehensively investigated anti-GBM effects PTC-209, novel specific inhibitor BMI-1. We found PTC-209 efficiently...
Summary Objective The effects of long‐term excessive maternal iodine intake on neonatal thyroid function are less known. This study aimed to assess the from drinking water functions both mothers and their neonates. Design Methods observational was performed in high ( HI ) areas adequate AI areas, including 384 healthy pregnant women late gestation (mean week 39·3 ± 1·6 weeks) newborns. Blood urine samples were obtained women, while cord blood Urinary concentration UIC evaluated. Results...
The clinical applications of the quantitative single photon emission computed tomography (SPECT)/computed (CT) are being expanded to a variety fields nuclear medicine. However, application SPECT/CT for evaluation Graves’ disease (GD) still needs further investigation. Our aim was investigate feasibility standard uptake value (SUV) thyroid diagnosis and GD. In this prospective multicenter study, 116 patients diagnosed with GD (Graves group) 74 healthy volunteers (control were enrolled from 8...
Background Glioblastoma (GBM) is the most common malignant brain tumor with poor clinical outcomes. Immunotherapy has recently been an attractive and promising treatment of extracranial malignancies, however, trials for GBM immunotherapy failed due to predominant accumulation tumor-associated microglia/macrophages (TAMs). Results High level LRIG2/soluble LRIG2 (sLRIG2) expression activates immune-related signaling pathways, which are associated prognosis in patients. LRIG2/sLRIGs promotes...
Iodine-131 (I-131) treatment and subsequent whole body iodine-131 scans (WBSs) are important in the management of differentiated thyroid carcinoma (DTC). Nevertheless, false positive benign lesions WBS should be interpreted with reliable anatomic imaging methodologies to differentiate from true metastases. We report a DTC case concurrent thyroglossal duct cyst (TDC), which is relatively uncommon compared an accompanying lingual thyroid. After remnant ablation, posttherapeutic showed stable...
We present a case of functioning metastatic follicular thyroid carcinoma (FTC) causing severe thyrotoxicosis despite four years 12 iodine-131 therapies (1.461 Ci cumulatively). Initially, the patient had ostalgia and fracture in right femur. Surgery-confirmed bone FTC thyroidectomy-confirmed FTC. One month later, treatment commenced. During follow-up, different sites showed outcomes. Lung metastases disappeared, thigh metastasis persisted, new head occurred pelvic deteriorated into huge mass...
Serum thyroglobulin (Tg) serves as a sensitive and easily available tumor marker for patients with metastatic differentiated thyroid carcinoma (m-DTC). The aim of the present study was to evaluate predictive value suppressed Tg changes (Δsup-Tg) and/or stimulated (Δsti-Tg) efficacy radioiodine therapy (RT).
This study investigated the clinical and functional significance of circ-AKT3 in hepatocellular carcinoma (HCC) its impact on tumor progression. Using qRT-PCR, we found reduced levels HCC tissues compared to adjacent liver samples. Clinical data revealed that low expression correlated with increased lymphatic distant metastasis. Functional experiments MHCC-97H Hep3B cells, chosen due their levels, demonstrated overexpression suppressed cell proliferation, invasion, migration. Bioinformatics...