A5003705114- Mast cells and histamine
- Monoclonal and Polyclonal Antibodies Research
- Cell Adhesion Molecules Research
- Immune Cell Function and Interaction
- Platelet Disorders and Treatments
- Rheumatoid Arthritis Research and Therapies
- Inflammasome and immune disorders
- Osteoarthritis Treatment and Mechanisms
- RNA Interference and Gene Delivery
- Adipose Tissue and Metabolism
- Virus-based gene therapy research
- Acute Myeloid Leukemia Research
- T-cell and B-cell Immunology
- Food Allergy and Anaphylaxis Research
- Autoimmune and Inflammatory Disorders Research
- Mesenchymal stem cell research
- Immune Response and Inflammation
- Chronic Lymphocytic Leukemia Research
- Ion Channels and Receptors
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Nutrition and Health in Aging
- Click Chemistry and Applications
- Viral Infections and Immunology Research
- Viral Infectious Diseases and Gene Expression in Insects
- Liver Disease Diagnosis and Treatment
Ehime University
2016-2025
Shanxi Agricultural University
2025
Taian City Central Hospital
2017-2024
Tsinghua University
2024
Sichuan University
2017-2023
South China University of Technology
2023
Qingdao National Laboratory for Marine Science and Technology
2018-2023
Laoshan Laboratory
2023
Chinese Academy of Fishery Sciences
2018-2023
State Key Laboratory of Food Science and Technology
2023
Bioadhesive performance can be compromised due to bleeding. Bleeding increases mortality. Adhesives with hemostatic function are of great significance. A sustainable and robust bioadhesive from okra is reported. The adhesive strength reaches around three six-fold higher than commercial fibrin on pigskin glass, respectively. gel presents high-pressure resistance underwater strength. In human blood experiments, the activate platelets, enhance adhesion activated release coagulation factors XI...
Background: In the past, most researchers paid more attention to biological activity of tea infusion and polyphenols; however, prebiotic role leaf powder is still unknown. Green rich in dietary fiber suggested be beneficial for human health. Only limited studies have looked at effects (which mainly contains fiber) on gut microbiota Objective: The purpose our study was determine green preventing hyperlipidemia understand its potential lipid-lowering mechanism. Design: Mice three treatment...
Quercetin is known for its ability to inhibit mast cell degranulation and reduce the release of inflammatory mediators. However, it has also been reported sensitize cells, potentially leading hyperresponsiveness. This necessitates careful optimization use in treatment chronic diseases. To fully harness quercetin’s therapeutic potential, this study investigated effects quercetin on rat basophilic leukemia (RBL-2H3) cells responsiveness over varying durations exposure. We employed...
Background Prehypertension is the preclinical stage of hypertension, which more likely to develop into hypertension than normal blood pressure. Although body may experience pathological changes at this stage, there are often no symptoms. Chinese medicine constitution theory widely used assess an individual’s health and disease status, provides a new method for prevention. The phlegm-dampness (PDC) main in prehypertension. Dysbiosis intestinal flora considered be related development...
Disequilibrium of CD4 + T-cell subpopulations in peripheral blood (PB) patients with primary immune thrombocytopenia (ITP) has been well established, whereas the profile bone marrow (BM) remains elusive.In present study, frequencies T helper 22 (Th22), Th17, Th1, Th2, follicular (Tfh) cells and regulatory (Tregs) as their effector cytokines BM PB from active ITP healthy controls (HCs) were determined.Results showed that Th22, Tfh significantly higher, but Treg number was remarkably lower...
Abstract Immune cells, including T B and osteoclasts, in conjunction with their associated cytokines, have been studied as primary molecular therapeutic targets for the management of rheumatoid arthritis (RA) patients. The increase cytosolic Ca2+ levels through activation store-operated release–activated channels (CRACs) is involved mediating a disparate array cellular responses by these immune cells. This study was undertaken to investigate feasibility efficiency regulation entry treatment...
Abstract Store-operated Ca2+ release–activated (CRAC) channels are involved in the pathogenesis of rheumatoid arthritis (RA) and have been studied as therapeutic targets management RA. We investigated efficacy safety CRAC inhibitors, including a neutralizing Ab (hCRACM1-IgG) YM-58483, treatment Patient-derived T cell B activity was suppressed by hCRACM1-IgG well YM-58483. Systemically constant, s.c. infused inhibitors showed anti-inflammatory human-NOD/SCID xenograft RA model protective...
Abstract Primary immune thrombocytopenia (ITP) is an autoantibody-mediated hemorrhagic disorder in which B cells play essential role. Previous studies have focused on peripheral blood (PB), but bone marrow (BM) not been well characterized. We aimed to explore the profile of B-cell subsets and their cytokine environments BM patients with ITP further clarify pathogenesis disease. subpopulations cytokine/chemokine receptors were detected by using flow cytometry. Plasma concentrations...
The regulated control of Ca 2+ influx is essential for the activation and function adaptive immune response, as a key regulator important transcription factors. To determine whether release‐activated (CRAC) channels contribute to abnormal behaviour T cells in patients with rheumatoid arthritis (RA), we performed cross‐sectional study characterize expression functional status CRACM1 RA patients. Peripheral blood was obtained from 50 patients, osteoarthritis (OA) healthy donors. We measured...
Aged women and premature ovarian insufficiency (POI) patients have residual dormant primordial follicles that are hard to be activated through a physiological process. However, there no effective safe drugs help them.
Abnormal store-operated calcium uptake has been observed in peripheral T lymphocytes of rheumatoid arthritis (RA) patients, and sustained intracellular signalling is known to mediate the functions many types immune cells. Thus, it hypothesized that regulating entry through CRACM1 (the pore-forming subunit release-activated (CRAC) channels; also as ORAI1) may be beneficial for management RA. Localized knockdown joints draining lymph nodes (DLNs) mice with collagen-induced (CIA) was achieved...
G-protein-coupled receptors (GPCRs) are membrane proteins distributed on the cell surface, and they may be potential drug targets. However, synthesizing GPCRs in vitro can challenging. Recently, some cell-free protein synthesis systems have been shown to produce a large amount of combined with chemical chaperones that include liposomes glycerol. Liposomes containing high concentrations glycerol known as glycerosomes, which used new delivery systems. Glycerosomes greater morphological...
Fibroblast growth factor 2 (FGF2) has been reported to play divergent roles in white adipogenic differentiation, however, whether it regulates thermogenesis of fat tissues remains largely unknown. We therefore aimed investigate the effect FGF2 on and elucidate underlying mechanisms. FGF2-KO wild-type (WT) mice were fed with chow diet high-fat (HFD) for 14 weeks. The brown mass, thermogenic capability, respiratory exchange ratio, hepatic deposition determined. In vitro experiments conducted...
Background: Antinuclear antibodies (ANAs) can be detected in about 30% of patients with primary immune thrombocytopenia (ITP), yet their relationship treatment response to rituximab remains elusive.Methods: we retrospectively reviewed the clinical records hospitalized adult ITP who were treated from three medical centers across China. Rituximab was given intravenously at 100 mg weekly for 4 weeks, or a single dose 375 mg/m2. All included had ANAs tested before treatment.Results: A total 287...