A5101683460- Nanoplatforms for cancer theranostics
- Cancer-related molecular mechanisms research
- Nanoparticle-Based Drug Delivery
- RNA modifications and cancer
- Graphene and Nanomaterials Applications
- RNA Interference and Gene Delivery
- 3D Printing in Biomedical Research
- Hemostasis and retained surgical items
- Hydrogels: synthesis, properties, applications
- Organophosphorus compounds synthesis
- Electrochemical sensors and biosensors
- Molecular Sensors and Ion Detection
- HVDC Systems and Fault Protection
- Circular RNAs in diseases
- Viral Infectious Diseases and Gene Expression in Insects
- Virus-based gene therapy research
- Cancer-related gene regulation
- Supramolecular Self-Assembly in Materials
- Synthesis and Reactivity of Sulfur-Containing Compounds
- Extracellular vesicles in disease
- Dye analysis and toxicity
- Surgical Sutures and Adhesives
- Nanomaterials for catalytic reactions
- Adsorption and biosorption for pollutant removal
- Advanced biosensing and bioanalysis techniques
Xinqiao Hospital
2017-2024
Army Medical University
2017-2024
Shanxi University
2019-2024
Guangzhou University
2023-2024
Southern Medical University
2021
Shanghai Jiao Tong University
2017-2021
Northeast Agricultural University
2021
Metal Matrix Cast Composites (United States)
2017
State Key Laboratory of Metal Matrix Composites
2017
First Affiliated Hospital Zhejiang University
2017
Abstract Background Gastric cancer (GC) is one of the most pernicious tumors that seriously harm human healthcare. GC metastasis prime cause failed treatment, but correlation between N6-methyladenosine (m6A) and was less reported. Methods Methylated RNA immunoprecipitation sequencing (MeRIP-seq) tissues conducted. Quantitative real-time PCR (qRT-PCR), western blotting immunohistochemistry (IHC) were taken to determine expression ALKBH5 in cell lines. RNA-seq together with MeRIP-qRT-PCR used...
Index modulation multiple access (IMMA) is a promising sixth-generation (6G) technique to prominently improve the spectral efficiency, energy system performance, and support massive connectivity, which considered as new extension of conventional non-orthogonal (NOMA). In this article, we first introduce basic principle IMMA, then investigate potential applications IMMA vehicular networks, reconfigurable intelligent surface (RIS) aided cooperative secure demonstrate flexibility practicability...
Gastrointestinal tract perforation is a full-thickness injury that causes bleeding and fatal infection of the peritoneum. This condition worsens in an acidic gastric environment which interferes with normal coagulation cascade. Current endoscopic clips to repair perforations are ineffective, metal or plastic occluders need secondary surgery remove them. Herein, we report self-expandable, endoscopy deliverable, adhesive hydrogel block perforation. We found nanosilica coating significantly...
Abstract Nature presents the most beautiful patterns through evolving. Here, a layered porous pattern in golden ratio (0.618) is reported from type of mushroom ‐ Dictyophora Rubrovalvata stipe (DRS). The hierarchical structure shows mathematical correlation with ratio. This unique leads to superior mechanical properties. gradient outside innermost endows it asymmetrical hydrophilicity. A model then developed predict and apply 3D printed structures. explored repair gastric perforation because...
A multifunctional targeted drug delivery platform (CDHA⁻MGO) has been successfully constructed by grafting β-cyclodextrin⁻hyaluronic acid polymers (CDHA) to Fe₃O₄⁻graphene oxide (MGO). The obtained CDHA⁻MGO nanocomposite good water-dispersibility, easy magnetic separation, high near-infrared (NIR) photothermal heating, and excellent biocompatibility. β-cyclodextrin-hyaluronic efficaciously enhance the doxorubicin (DOX) loading amount up 485.43 mg·g-1. Meanwhile, provides a facile response...
Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer, accounting for one-sixth all malignant tumors, and mortality rate HCC ranks second among cancer-related deaths. Increasing evidence has recently shown that long non-coding RNAs (lncRNAs) play an important role in cancer occurrence progression, including HCC. Cancer susceptibility candidate 15 (CASC15), a lncRNA, been reported to be involved melanoma progression phenotype switching. However, function CASC15 human...
Endoscopic submucosal dissection (ESD) is a common procedure to treat early and precancerous gastrointestinal lesions. Via injection, liquid cushion created lift separate the lesion malignant part from muscular layer where formed indispensable space convenient for endoscopic incision. Saline most injection liquid, but pad lasts only short time, thus repeated injections increase potential risk of adverse events. Hydrogels with high osmotic pressure viscosity are used as an alternate; however,...
Bioadhesive performance can be compromised due to bleeding. Bleeding increases mortality. Adhesives with hemostatic function are of great significance. A sustainable and robust bioadhesive from okra is reported. The adhesive strength reaches around three six-fold higher than commercial fibrin on pigskin glass, respectively. gel presents high-pressure resistance underwater strength. In human blood experiments, the activate platelets, enhance adhesion activated release coagulation factors XI...
It has been shown that the adeno-associated virus (AAV) vector can deliver VEGF gene efficiently into ischemic mouse myocardium. However, AAV genomes be found in extracardiac organs after intramyocardial injection. To limit unwanted expression other than heart, we tested use of cardiac myosin light chain 2v (MLC-2v) promoter and hypoxia-response element to mediate cardiac-specific hypoxia-inducible expression. An vector, MLCVEGF, with 250 bp MLC-2v nine copies driving expression, was...
Theranostic agents based on magnetic resonance imaging (MRI) and photothermal therapy (PTT) play an important role in tumor therapy. However, the available theranostic are facing great challenges such as biocompatibility, MRI contrast effect conversion efficiency (η). In this work, mesoporous polydopamine nanoparticles (MPDAPs/Mn) were prepared PTT combined nanoplatforms, of which high loading manganese ions specific surface areas enable good excellent efficiency, respectively. The MPDAPs/Mn...
A three-dimensional reduced graphene oxide nanomaterial with β-cyclodextrin modified glassy carbon electrode (3D-rGO/β-CD/GCE) was constructed and used to detect the electrochemical behavior of dopamine (DA). The nanocomposite materials were characterized by scanning electron microscopy (SEM), infrared spectrometry (FT-IR), Raman spectrogram thermogravimetric analysis (TGA), which showed that β-CD well on 3D a porous structure. properties different electrodes investigated cyclic voltammetry...
Abstract Polymeric drug delivery system termed as “polyprodrug amphiphile” poly(2‐methylacryloyloxyethyl phosphorylcholine)‐ b ‐poly(10‐hydroxy‐camptothecin methacrylate (pMPC‐ ‐pHCPT) is developed for the prolonged‐acting cancer therapy. It obtained by two‐step reversible addition–fragmentation chain transfer polymerization of zwitterionic monomer MPC and an esterase‐responsive polymerizable prodrug methacrylic anhydride–CPT, respectively. This diblock polymer composed both antifouling...
Mesoporous polydopamine nanoparticles with various morphologies can be easily synthesized and controlled. In mice subcutaneous ATC, intravenous injection of 131 I-CPDA achieve the robust antitumor effects.
With the development of blue laser endoscopy (BLE) technique, it's often used to diagnose early gastric cancer (EGC) by morphological changes blood vessels through BLE. However, EGC is still not obvious identify, resulting in a high rate missed diagnosis. Molecular imaging can show tumors at molecular level, which provides possibility for diagnosing EGC. Therefore, developing probe that visually monitors under BLE particularly necessary. Herein, bis-pyrene (BP) based nanoprobe (BP-FFVLK-(PEG)-RGD, M
High human telomerase reverse transcriptase (hTERT) expression is related to severe Colorectal Cancer (CRC) progression and negatively CRC patient survival. Previous studies have revealed that hTERT can reduce cancer cellular reactive oxygen species (ROS) levels accelerate progression; however, the mechanism remains poorly understood. NFE2-related factor 2 (NRF2) a molecule plays significant role in regulating ROS homeostasis, but whether there correlation between NRF2 unclear. Here, we...
Palladium@gold nanoparticle modified three-dimensional-reduced graphene oxide (3D-rGO/Pd@Au) was coupled with carboxymethyl-β-cyclodextrin to form a novel nanocomposite (3D-rGO/Pd@Au/CM-β-CD). The 3D-rGO/Pd@Au/CM-β-CD served as chiral sensing interface for the electrochemical enantiorecognition of tyrosine (Tyr) via differential pulse voltammetry (DPV) approach. 3D-rGO/Pd@Au demonstrates good electrical conductivity and efficient catalytic activity an indicator. Simultaneously, CM-β-CD...