A5100779547- Nanoparticle-Based Drug Delivery
- Nanoplatforms for cancer theranostics
- Asphalt Pavement Performance Evaluation
- RNA Interference and Gene Delivery
- Infrastructure Maintenance and Monitoring
- Advanced biosensing and bioanalysis techniques
- Advanced Polymer Synthesis and Characterization
- Polymer Nanocomposites and Properties
- Electrochemical sensors and biosensors
- Dendrimers and Hyperbranched Polymers
- Erythrocyte Function and Pathophysiology
- Luminescence and Fluorescent Materials
- Hydrogels: synthesis, properties, applications
- Hemoglobinopathies and Related Disorders
- Photodynamic Therapy Research Studies
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Polymer composites and self-healing
- Cancer, Hypoxia, and Metabolism
- Advanced Nanomaterials in Catalysis
- Advanced Sensor and Energy Harvesting Materials
- Advanced Drug Delivery Systems
- Supramolecular Self-Assembly in Materials
- Petroleum Processing and Analysis
- Photonic Crystals and Applications
- Acute Myeloid Leukemia Research
Shanghai Jiao Tong University
2016-2025
Shenyang Jianzhu University
2022-2025
Northeast Normal University
2024
BGI Group (China)
2024
Shanxi Medical University
2024
South China University of Technology
2024
BGI Research
2024
Yanbian University
2012-2023
Renji Hospital
2011-2023
First Affiliated Hospital of Guangzhou University of Chinese Medicine
2023
This review presents the recent developments in research hotspots of advanced functional polymers; their concepts, design strategies, and applications are briefly discussed.
A novel drug carrier with dual triggerable release properties based on keratin graft poly(ethylene glycol) (keratin-g-PEG) copolymers is reported. Keratin-g-PEG different densities are synthesized through thiol–ene click chemistry. Taking advantage of the amphiphilicity and thiol groups copolymer, nanoparticles stabilized PEG chains as core, bearing glutathione (GSH) cleavable cross-links, fabricated in aqueous solutions. The keratin-g-PEG copolymer can serve excellent carriers for...
Nanocapsules of organophosphorous hydrolase with enhanced enzyme activity and stability are prepared via in situ polymerization, providing a novel class nanoparticles for the decontamination detoxification organophosphates such as chemical warfare agents pesticides. Using nanocapsules building blocks, bioactive nanocomposites also fabricated, enabling their use organophosphate protection. As service to our authors readers, this journal provides supporting information supplied by authors....
The self-assembly and pH- thermo-sensitivities properties of hydroxypropyl cellulose-graft-poly(N,N-dimethyl aminoethyl methacrylate) (HPC-g-PDMAEMA) copolymers in aqueous solutions were investigated by transmittance, dynamic light scattering (DLS), 1H NMR spectroscopy. Micelles with different structure can be formed varying either pH value or temperature. At low pH, e.g., 3.0, the HPC backbone copolymer collapse to form core micelles stabilized protonated PDMAEMA side chains on surface upon...
Asphalt oxidative aging at constant temperature is characterized by a declining fast-rate period and constant-rate period. While reaction kinetics are known for many asphalt materials, much less about the equally important region. Fifteen modified unmodified asphalts were aged five temperatures in 1 atm air, with samples collected during both periods. Arrhenius parameters obtained reactions; an additional parameter characterizes total oxidation that occurs fast-rate, first-order reaction....
Rationale: Photodynamic therapy (PDT), an O 2 -dependent treatment for inhibition of cancer proliferation, suffers from the low therapeutic effect in clinical application due to hypoxic microenvironment tumor cells.Methods: To overcome this obstacle, a stimuli-responsive drug delivery system with self-sufficiency effective PDT was developed.In study, pH-responsive aerobic nanoparticles were prepared by electrostatic interaction between -evolving protein Catalase and Chitosan.Subsequently,...
Supramolecular chemistry provides a means to integrate multi-type molecules leading dynamic organization. The study of functional nanoscale drug-delivery systems based on supramolecular interactions is recent trend. Much work has focused the design building blocks and engineering integration, with goal optimized delivery behavior enhanced therapeutic effect. This review introduces advances in designs drug delivery. affinity can act as main driving force either self-assembly carriers or...
Iron accumulation in substantia nigra pars compacta (SNpc) has been proved to be a prominent pathophysiological feature of Parkinson's diseases (PD), which can induce the death dopaminergic (DA) neurons, up-regulation reactive oxygen species (ROS), and further loss motor control. In recent years, iron chelation therapy demonstrated an effective treatment for PD, shown significant improvements clinical trials. However, current chelators are suboptimal due their short circulation time, side...
Abstract Combinatorial therapy based on chemotherapeutic drugs and gene agents to achieve synergistic antitumor effects has emerged as a new direction for cancer treatment. However, simple efficient co‐delivery of those two drug categories remains key challenge in this hot area owing their substantially different pharmacodynamics, impeding the translational potentials combinatorial approaches. To address issue, herein we propose strategy site‐specifically graft camptothecins (CPTs,...
A new type of cellulose derivative was synthesized by means conjugating cysteamine to hydroxypropyl (HPC) and the degree thiol groups could be controlled feed ratio reactants. The thiolated HPC (HPC–SH) maintains thermosensitivity on chain can oxidized disulfide bonds. Cytotoxity tests performed MG-63 cells proved that HPC–SH is not harmful cells. Nanogels fabricated self-association HPC–HS in solution at 45 °C then oxidation bonds occurs stabilize associated structure. crosslinking nanogels...
The ability to accurately predict pavement temperature variation with time and depth is critical calculating binder oxidation in pavements, understanding asphalt material behavior, predicting performance. In this work, an improved one-dimensional model, coupled methods obtain model-required climate data from available databases optimization of site-specific parameters was developed calculate hourly temperatures nationwide. Hourly solar radiation daily average wind speed were obtained...
Abstract: The expression of multiple receptors on intestinal epithelial cells enables an actively targeted carrier to significantly enhance the oral delivery payloads. Conjugating receptors' ligands surfaces a particulate-delivery system allows site-specific targeting. Here, we used taurocholic acid (TCA) as ligand for uptake nanostructured lipid carriers (NLCs) mediated by bile-acid transporter improve bioavailability curcumin (Cur). First, synthesis TCA–polyethylene glycol 100–monostearate...
Thermoplastic polyurethane elastomers (TPUs) are widely used in a variety of applications as result flexible and superior performance. However, few scholars pay close attention on the design synthesis TPUs through self-determined laboratory process, especially definite chemical structures upon influence properties. To investigate properties synthesized modifier based structure, firstly each kind unknown structure composition ratio was determined by using new method. Furthermore, thermal...
A lateral flow strip for tobramycin can provide on-demand dual-detection modes based on the optical and catalytic properties of Au@Pt NPs.
Background: Hepatocellular carcinoma (HCC) is associated with chronic inflammation caused by different factors; especially, the interaction of inflammatory pathways and bile acids (BAs) can affect hepatocyte proliferation, death, regeneration, but whether BAs promote HCC progression through mechanisms still unclear. Methods results: By examining cancer tumor-adjacent tissue BA levels genes homeostasis in 37 patients, we found that total (TBAs) were decreased 36% varying degrees changes...
Polyvinylidene fluoride (PVDF) latex nanoparticles serve as a versatile platform for surface modification due to their role precursors in PVDF manufacturing. However, the strong chemical stability and poor compatibility of present significant challenges effective modification. To address this, we developed method that facilitates through chain entanglement. By employing monomer swelling emulsion polymerization, poly(meth)acrylate (PA) monomers are incorporated into subsequently polymerized....
The prompt and accurate detection of tunnel lining cracks is essential for maintaining the safety reliability tunnels. Deep learning-based approaches have significantly advanced automated crack detection, delivering improved efficiency precision in inspection. Nevertheless, intricate characteristics cracks, manifesting as fine, elongated, irregular structures, pose substantial challenges deep semantic segmentation networks, hindering their ability to achieve comprehensive identification....
To determine whether immune-enhanced enteral nutrition (EN) was effective on nutritional status, immune function, surgical outcomes and days of hospitalization after total gastrectomy for patients with advanced gastric cancer (AGC).From August 2005 to May 2011, 78 AGC who underwent a were enrolled divided randomly into three groups: EN (EN + glutamine [Gln]) group, standard group control group. Serum parameters including protein, albumin, proalbumin transferrin examined preoperative day 1,...