A5102021918- Nanoplatforms for cancer theranostics
- Photodynamic Therapy Research Studies
- Dermatologic Treatments and Research
- Dendrimers and Hyperbranched Polymers
- Luminescence and Fluorescent Materials
- Facial Rejuvenation and Surgery Techniques
- Cancer, Hypoxia, and Metabolism
- Salivary Gland Disorders and Functions
- Acne and Rosacea Treatments and Effects
- Advanced Nanomaterials in Catalysis
- RNA Interference and Gene Delivery
- Oral Health Pathology and Treatment
- melanin and skin pigmentation
- Blood properties and coagulation
- Oral and Maxillofacial Pathology
- Nail Diseases and Treatments
- Wound Healing and Treatments
- Fractional Differential Equations Solutions
- Laser Applications in Dentistry and Medicine
- Advanced Mathematical Modeling in Engineering
- Molecular Sensors and Ion Detection
- Platelet Disorders and Treatments
- Dermatological diseases and infestations
- Reconstructive Facial Surgery Techniques
- Lattice Boltzmann Simulation Studies
Shanghai Ninth People's Hospital
2009-2024
Shanghai Jiao Tong University
2009-2024
National Clinical Research Center for Digestive Diseases
2024
Stomatology Hospital
2020
National Clinical Research
2019
Shanghai Stomatological Hospital
2017
University of Electronic Science and Technology of China
2002
The noninvasive nature of photodynamic therapy (PDT) enables the preservation organ function in cancer patients.However, PDT is impeded by hypoxia tumor microenvironment (TME) caused high intracellular oxygen (O 2 ) consumption and distorted blood vessels.Therefore, increasing generation TME would be a promising methodology for enhancing PDT.Herein, we proposed concept ferroptosis-promoted based on biochemical characteristics cellular ferroptosis, which improved efficacy significantly...
Recent years have witnessed significant progress in the field of two-photon-activated photodynamic therapy (2P-PDT). However, traditional photosensitizer (PS)-based 2P-PDT remains a critical challenge clinics due to its low two-photon absorption (2PA) cross sections. Here, we propose that therapeutic activity current PSs can be enhanced through combination excited fluorescence resonance energy transfer (FRET) strategy and photothermal effect near-infrared (NIR) light. A core–shell...
Rationale: Photodynamic therapy (PDT), an O 2 -dependent treatment for inhibition of cancer proliferation, suffers from the low therapeutic effect in clinical application due to hypoxic microenvironment tumor cells.Methods: To overcome this obstacle, a stimuli-responsive drug delivery system with self-sufficiency effective PDT was developed.In study, pH-responsive aerobic nanoparticles were prepared by electrostatic interaction between -evolving protein Catalase and Chitosan.Subsequently,...
A combination of nanoparticle delivery Wnt-1 siRNA with photodynamic therapy was realized by inhibiting epithelial–mesenchymal transition.
A pH-responsive fluorinated chitosan-chlorin e6 (FC-Ce6) was employed here for the intracellular delivery of catalase to relieve hypoxic micro-environment.
Recent years have witnessed significant progress in molecular probes for cancer diagnosis. However, the conventional are designed to be “always‐on” by attachment of tumor‐targeting ligands, which limits their abilities diagnose tumors universally due variations targeting efficiency and complex environment different cancers. Here, it is proposed that a color‐convertible, activatable probe responding universal tumor microenvironment tumor‐specific diagnosis without ligands. Based on hallmark...
To determine the optimal time to apply a fractional CO 2 laser for treatment of postsecondary repair scars in patients with cleft lip.Forty-two linear scarring after lip were recruited from November 2021 October 2022. A single-blind, randomized, controlled cohort study was conducted examine impact compared conventional conservative treatment. Thirty started at 1 month ( n = 10), 3 months and 6 10) postoperatively, 12 control group. Each patient treated high-energy low-density times an...
Near-infrared-sensitive supramolecular hyperbranched conjugated unimicelles were constructed for controlled drug release <italic>via</italic> two-photon excited fluorescence resonance energy transfer.
This study is the first prospective within-patient self-controlled research seeking to investigate safety and efficacy of 595 nm pulsed-dye laser (PDL) for treatment cleft-lip scars.
The excellent efficacy is mitigated by the limited safety profile of microfocused ultrasound procedures. We sought to assess and tightening a novel ultrasound. randomized middle lower face submental region participants were treated with device using following transducers: M4.5, D4.5, M3.0, D3.0. Improvement in paired comparison pretreatment posttreatment photographs, three-dimensional (3D) volumetric assessments, skin thickness measured B-ultrasonography, photoaging parameters evaluated....
Reflectance confocal microscopy (RCM) is a non‑invasive tool that provides real‑time microscopic images and relatively high‑resolution tissue images. This technique link between clinical examination histopathology. RCM has been used to detect skin diseases also recently applied of the oral mucosa. The present study aimed explore features lichen planus (OLP) using RCM. A total 47 patients with OLP exhibiting reticular pattern, were included in study. lesion sites healthy adjacent...
The present study aimed to evaluate the efficacy of krypton laser photodynamic therapy (PDT) with PsD‑007 for treatment oral mucosa dysplasia in 9,10‑dimethyl‑1,2‑benzanthracene (DMBA)‑treated hamsters. A DMBA‑induced hamster cheek pouch model precancerous lesions was created and resultant 25 hamsters were divided into five groups. right side treated PDT left used as positive control. Following systemic anesthesia, an incision made groin area expose femoral vein. administered intravenously...
In the present work, we pioneered a coordinated self-assembly approach aimed at fabricating carrier-free hybrid nanoparticles to address inherent challenges of anaerobic microenvironment and oxidative resistance induced by reductive glutathione (GSH) in photodynamic therapy (PDT). these nanoparticles, protoporphyrin IX (PP), HIF-1α inhibitor N, Nʹ-(2,5-Dichlorosulfonyl) cystamine KC7F2 (KC), cofactor Fe3+ hydrogen bond coordination interaction. The exhibited efficient cellular uptake CAL-27...
Atrophic acne scars (AAS) are disfiguring and permanent changes caused by inflammatory acne. Fractional carbon dioxide is a common ablative device used to treat this condition. However, issues such as unclear effectiveness, frequent treatments, potential side effects exist. In recent years, recombinant human epidermal growth factor (rhEGF) has also been frequently reported for its application in the treatment of scars.
BACKGROUND Multiple lasers have been used for the treatment of café au lait macules (CALMs) with various results. Objective tools to predict therapeutic efficacy CALMs is lacking. OBJECTIVE To determine whether reflectance confocal microscopy (RCM) characteristics correlate response laser treatment. MATERIALS AND METHODS All CAMLs underwent RCM examination length and density dermal papillae followed by 3 sessions Q-switched alexandrite (QSAL). A visual analog scale was assess clinical...
A thermodynamically consistent phase-field model is introduced for simulating multicellular deformation, and aggregation under flow conditions. In particular, a Lennard-Jones type potential proposed the framework cell-cell, cell-wall interactions. second-order accurate in both space time $C^0$ finite element method to solve governing equations. Various numerical tests confirm convergence, energy stability, nonlinear mechanical properties of cells scheme. Vesicles with different adhesion are...