A5100332779- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- RNA modifications and cancer
- Cancer, Hypoxia, and Metabolism
- RNA Research and Splicing
- Circular RNAs in diseases
- SARS-CoV-2 and COVID-19 Research
- Lymphoma Diagnosis and Treatment
- Monoclonal and Polyclonal Antibodies Research
- Viral-associated cancers and disorders
- Microtubule and mitosis dynamics
- Vaccine Coverage and Hesitancy
- Epigenetics and DNA Methylation
- Glycosylation and Glycoproteins Research
- COVID-19 Clinical Research Studies
- vaccines and immunoinformatics approaches
- Immune Cell Function and Interaction
- Cancer-related gene regulation
- Caveolin-1 and cellular processes
- Cancer, Lipids, and Metabolism
- Hepatocellular Carcinoma Treatment and Prognosis
- Supercapacitor Materials and Fabrication
- Bioinformatics and Genomic Networks
- Ubiquitin and proteasome pathways
- Advanced Biosensing Techniques and Applications
Ruijin Hospital
2019-2025
Shanghai Jiao Tong University
2009-2025
RWTH Aachen University
2025
Southern Medical University
2022-2025
Shanghai Institute of Hematology
2019-2024
Shanghai Municipal Center For Disease Control Prevention
2022-2024
Shanghai First People's Hospital
2024
Anhui University of Traditional Chinese Medicine
2023
Tsinghua University
2019-2023
Nanfang Hospital
2022
Natural killer/T cell lymphoma (NKTCL) is an aggressive and heterogeneous entity of non-Hodgkin lymphoma, strongly associated with Epstein-Barr virus (EBV) infection. To identify molecular subtypes NKTCL based on genomic structural alterations EBV sequences, we performed multi-omics study 128 biopsy samples newly diagnosed defined three prominent subtypes, which differ significantly in origin, gene expression, transcriptional signatures, responses to asparaginase-based regimens targeted...
Abstract Background Limited data are available on the effectiveness of inactivated and Ad5-nCoV COVID-19 vaccines in real-world use—especially against Omicron variants SARS-CoV-2 infection-naïve population. Methods A matched case-control study was conducted among people aged ≥ 3 years between 2 December 2021 13 May 2022. Cases were SARS-CoV-2-infected individuals, individuals with severe/critical COVID-19, or COVID-19-related deaths. Controls selected from consecutively test-negative at same...
Although systemic or local inflammation, commonly featured by cytokine activation, is implicated in patients with bone loss, the underlying mechanisms are still elusive. As microRNAs (miR), a class of small non-coding RNAs involved essential physiological processes, have been found cells, we aimed to investigate role miR for modulating osteogenesis inflammatory milieu using human marrow mesenchymal stem cells (hBM-MSCs). Induced proinflammatory TNF-α, miR-150-3p was identified as key player...
Abstract We conducted a matched retrospective cohort study of two cohorts to estimate inactivated vaccine effectiveness (VE) and its comparative booster dose among older people in Shanghai. Cohort 1 consisted vaccinated group (≥1 dose) an unvaccinated (3,317,475 pairs), 2 fully (2,084,721 pairs). The Kaplan–Meier method Cox regression models were used risk hazard ratios (HRs) outcomes. For 1, the overall estimated VEs ≥1 against SARS-CoV-2 infection, severe/critical Covid-19, Covid-19...
Iron accumulation in substantia nigra pars compacta (SNpc) has been proved to be a prominent pathophysiological feature of Parkinson's diseases (PD), which can induce the death dopaminergic (DA) neurons, up-regulation reactive oxygen species (ROS), and further loss motor control. In recent years, iron chelation therapy demonstrated an effective treatment for PD, shown significant improvements clinical trials. However, current chelators are suboptimal due their short circulation time, side...
This study aimed to reveal the effects and possible mechanism of terpinen-4-ol, main component tea tree oil (TTO), on disease resistance strawberry fruit. When TTO its components were compared decay development in fruit inoculated with Botrytis cinerea after treatment, treated terpinen-4-ol showed lowest incidence (44.4%) 48 h also smallest lesion diameter during whole storage. indicates that induces highest other components. Untargeted metabolomic analysis treatment strongly activated...
Abstract Background Diffuse large B‐cell lymphoma (DLBCL) is an aggressive subtype of lymphoma, and multiple extranodal involvement (ENI) indicates adverse clinical outcomes. The aim this study was to investigate the influence oncogenic mutations tumor microenvironment alterations on ENI in DLBCL. Methods features 1960 patients with newly diagnosed DLBCL were analyzed, DNA RNA sequencing performed 670 349 patients, respectively. Oncogenic compared according evaluated zebrafish...
Antibodies play essential roles in both diagnostics and therapeutics. Epitope mapping is to understand how an antibody works protect intellectual property. Given the millions of antibodies for which epitope information lacking, there a need high-throughput mapping. To address this, we developed strategy, Antibody binding Mapping (AbMap), by combining phage displayed peptide library with next-generation sequencing. Using AbMap, profiles peptides bound 202 were determined single test, linear...
Metabolic reprogramming plays an essential role on lymphoma progression. Dysregulation of glutamine metabolism is implicated in natural-killer T-cell (NKTCL) and tumor cell response to asparaginase-based anti-metabolic treatment.To understand the metabolomic alterations determine potential therapeutic target asparaginase, we assessed profile using liquid chromatography-mass spectrometry serum samples 36 NKTCL patients, integrated targeted metabolic analysis RNA sequencing 102 patients. The...
Abstract Tubulin, the primary constituent of microtubules, is a GTP‐binding protein with structural similarities to other proteins. Whereas microtubules have been implicated as modulators adenylate cyclase system, mechanism this regulation has elusive. polymerized hydrolysis‐resistant GTP analog, 5′‐guanylylimidodiphosphate [Gpp(NH)p], can promote inhibition synaptic membrane which persists subsequent washing. Tubulin Gpp(NH)p bound was slightly less potent than free in cyclase, but tubulin...
Abstract Most gene therapies exert their actions via manipulation of hepatocytes (parenchymal cells) and the reasons behind suboptimal performance synthetic mRNA in non‐parenchymal cells (NPC) such as Kupffer (KC), liver macrophages, remain unclear. Here, spatio‐temporal distribution encoding enhanced green fluorescent protein ( Egfp ), siRNA, or both co‐encapsulated into lipid nanoparticles (LNP) vivo using real‐time intravital imaging is investigated. Although KC demonstrate comparable...
Short-term recurrence after surgery severely threatens patients' lives and leads to dismal outcomes in hepatocellular carcinoma (HCC). Our previous research proposed the abundance of binuclear hepatocytes (ABH) as an independent indicator related cytokinesis regulator Anillin significantly associated with HCC recurrence. The exact mechanism ABH modulation has not been clearly illustrated. In this study, we intensively investigated probable regulation noticed a contradiction between E2F7...
Functional analysis using the Gene Ontology (GO) is crucial for array analysis, but it often difficult researchers to assess amount and quality of GO annotations associated with different sets gene products. In many cases source date were last updated not apparent, further complicating a researchers' ability data provided. Moreover, biocurators need ensure that maintained optimal functional processes are most relevant their research community. We report Annotation Quality (GAQ) score,...
The electrolytes containing halide-free inorganic magnesium salt Mg(BH4)2 dissolved in ether solvents have shown reversible Mg deposition-dissolution performance. Herein, we improved the anodic stability of on non-inert stainless-steel electrode by mixing PP14TFSI ionic liquid with tetraglyme (TG) and dimethoxyethane (DME) solvents. effect ratios concentrations electrochemical behavior electrolyte were investigated. High stability, good conductivity, excellent cycling efficiency, feasibility...
A massively parallel array of monoclonal antibodies enables rapid antibody development and target discovery across species.
PM2.5 plays an important role in the physiological and pathological progression of lung cancer. Lentinan exerts antitumor activity many kinds human cancers. Plasmacytoma variant translocation 1 (PVT1) However, underlying molecular mechanism PVT1 lentinan PM2.5-exposed cancer are still largely unknown. Our study confirmed that exposure induced production inflammatory factors, epithelial–mesenchymal transition (EMT) migration cells. exerted effects by inhibiting EMT, suppressed...
Purpose The present study was designed to explore the prognostic value of preoperative inflammatory and nutritional biomarkers in stage III gastric cancer (GC) patients with adjuvant chemotherapy develop a novel scoring system called inflammatory-nutritional score (INPS). Methods A total 513 pathological GC undergoing radical gastrectomy followed by from 2010 2017 were enrolled study. Clinicopathological characteristics blood test parameters individual collected. least absolute shrinkage...
Objective: To evaluate phenotypic drug susceptibility and non-nucleoside reverse transcriptase inhibitor hypersusceptibility as predictors of the time to virological failure. Design: In a randomized clinical trial, was retrospectively determined among 131 exclusively nucleoside (NRTI)-experienced patients with baseline HIV-RNA levels greater than 2000 copies/ml. Subjects were assigned two NRTI drugs randomly nelfinavir, efavirenz, or both. Virological failure defined measurements copies/ml...
Innumerable opportunities for new genomic research have been stimulated by advancement in high-throughput next-generation sequencing (NGS). However, the pitfall of NGS data abundance is complication distinction between true biological variants and sequence error alterations during downstream analysis. Many correction methods developed to correct erroneous reads before further analysis, but independent evaluation impact such dataset features as read length, genome size, coverage depth on...
Metastasis‑associated lung adenocarcinoma transcript 1 (MALAT1) is a long non‑coding RNA that overexpressed in various human cancers, including breast cancer. Evidence has associated the function of α‑2,8‑sialyltransferase (ST8SIA) family with The present study aimed to investigate potential roles MALAT1 cancer development and progression using analyses both tissues cell lines. mRNA levels MALAT1, microRNA (miR)‑26a/26b ST8SIA4 were detected by reverse transcription‑quantitative PCR...