A5043734101- Lymphoma Diagnosis and Treatment
- Renal cell carcinoma treatment
- Viral-associated cancers and disorders
- Antibiotics Pharmacokinetics and Efficacy
- Renal and related cancers
- Lung Cancer Treatments and Mutations
- CNS Lymphoma Diagnosis and Treatment
- Pneumonia and Respiratory Infections
- Cancer Genomics and Diagnostics
- CAR-T cell therapy research
- Chronic Lymphocytic Leukemia Research
- Sarcoma Diagnosis and Treatment
- Breast Cancer Treatment Studies
- Antibiotic Resistance in Bacteria
- Cancer-related gene regulation
- Cancer Immunotherapy and Biomarkers
- Immune Cell Function and Interaction
- HER2/EGFR in Cancer Research
- Cancer Mechanisms and Therapy
- Acute Lymphoblastic Leukemia research
- Peptidase Inhibition and Analysis
- RNA modifications and cancer
- Advanced Radiotherapy Techniques
- Single-cell and spatial transcriptomics
- Advances in Oncology and Radiotherapy
Ruijin Hospital
2019-2025
Shanghai Jiao Tong University
2013-2025
Hospital of Hebei Province
2018-2025
Hebei Medical University
2009-2024
Central South University
2024
Jilin University
2013-2023
First Hospital of Jilin University
2013-2023
Shanghai Institute of Hematology
2023
Beijing Sport University
2021
Zhejiang Chinese Medical University
2019-2020
Abstract Genetic classification helps to disclose molecular heterogeneity and therapeutic implications in diffuse large B-cell lymphoma (DLBCL). Using whole exome/genome sequencing, RNA-sequencing, fluorescence situ hybridization 337 newly diagnosed DLBCL patients, we established a simplified 38-gene algorithm (termed ‘LymphPlex’) based on the information mutations of 35 genes rearrangements three ( BCL2 , BCL6 MYC ), identifying seven distinct genetic subtypes: TP53 Mut mutations), MCD-like...
Neuropathy is a feature more frequently observed in pancreatic ductal adenocarcinoma (PDAC) than other tumors. Schwann cells, the most prevalent cell type peripheral nerves, migrate toward tumor cells and associate with poor prognosis PDAC. To unveil effects of on neuro-stroma niche, here we perform single-cell RNA-sequencing microarray-based spatial transcriptome analysis PDAC tissues. Results suggest that may drive cancer-associated fibroblasts (CAFs) to malignant subtypes: basal-like...
Abstract Single-cell and spatial transcriptome sequencing, two recently optimized sequencing methods, are increasingly used to study cancer related diseases. Cell annotation, particularly for malignant cell is essential crucial in-depth analyses in these studies. However, current algorithms lack accuracy generalization, making it difficult consistently rapidly infer cells from pan-cancer data. To address this issue, we present Cancer-Finder, a domain generalization-based deep-learning...
Abstract Background Diffuse large B‐cell lymphoma (DLBCL) is an aggressive subtype of lymphoma, and multiple extranodal involvement (ENI) indicates adverse clinical outcomes. The aim this study was to investigate the influence oncogenic mutations tumor microenvironment alterations on ENI in DLBCL. Methods features 1960 patients with newly diagnosed DLBCL were analyzed, DNA RNA sequencing performed 670 349 patients, respectively. Oncogenic compared according evaluated zebrafish...
Abstract Diffuse large B-cell lymphoma (DLBCL) is a highly aggressive subtype of with clinical and biological heterogeneity. The International Prognostic Index (IPI) shows great prognostic capability in the era rituximab, but signatures IPI remain to be discovered. In this study, we analyzed data cohort 2592 patients newly diagnosed DLBCL. Among them, 1233 underwent DNA sequencing for oncogenic mutations, 487 RNA microenvironment (LME) alterations. Based on scores, were categorized into 4...
Introduction. Germline mutations have been described in multiple renal neoplasm entities the fifth edition of World Health Organization Classification Urinary and Male Genital Systems. However, our knowledge neoplasms with germline remains limited. Methods. To expand understanding, 15 tumors were retrieved from 284 that underwent next-generation sequencing, including well-known VHL, FH, SDHB, FLCN, TSC1, less common genes such as MUTYH, NF2, BARD1. Results. Interesting findings included...
ABSTRACT The pharmacokinetic profile of linezolid still needs further definition, and insufficient or excessive exposure may lead to treatment failure development adverse events. Our study aimed establish a population (PPK) model for in children with bacterial infections, develop an optimal dosage, evaluate its efficacy safety. A total 157 plasma samples from 80 patients were utilized PPK modeling. one-compartment first-order elimination was most suitable describing the PK characteristics...
Ceftazidime, a third-generation cephalosporin, can be used for the treatment of adults and children with infections due to susceptible bacteria. To date, pediatric pharmacokinetic data are limited in infants, therefore we aimed evaluate population pharmacokinetics ceftazidime infants define appropriate dose optimize treatment. Blood samples were collected from treated ceftazidime, concentrations drug quantified by high-performance liquid chromatography UV detection (HPLC-UV). A analysis was...
Context.— Fumarate hydratase (FH)–deficient renal cell carcinoma (RCC) rarely exhibits a predominant tubulocystic architecture with few other components. RCC pure tubules and cysts lined by eosinophilic tumor cells prominent nucleoli would raise the diagnosis of RCC. It is important to differentiate 2 entities because they lead different outcomes. Objective.— To address this concern, multicenter study was implemented explore useful clinicopathologic features in differentiation between...
Chinese children are more susceptible to the development of thiopurine-induced leukopenia compared with Caucasian populations. The aim our study was establish a 6-mercaptopurine (6-MP) dose-concentration-response relationship through exploration pharmacogenetic factors involved in toxicities paediatric patients afflicted by acute lymphoblastic leukaemia (ALL).Blood samples were obtained from ALL treated 6-MP. We determined metabolite steady-state concentrations 6-MP red blood cells (RBCs)...
Interferon regulatory factor 4 (IRF4) rearrangement is commonly detected in patients with a range of lymphoproliferative malignancies, including myelomas, large B cell lymphomas and low‐grade neoplasms. However, IRF4 generally relatively rare finding these latter two cancer types. In the present article, we describe summarize clinicopathological genetic features 13 cases lymphoma rearrangement, 12 one case exhibiting such rearrangement. These were six females seven males between 14 71 years...
The incidence of diffuse large B-cell lymphoma (DLBCL) increases by age and older DLBCL are commonly related to poor prognosis. However, the clinical biological features patients remain be determined. A total 2,445 with newly diagnosed were enrolled for data analysis according at diagnosis, tumor samples 1,150 assessed DNA sequencing 385 RNA sequencing. Older presented advanced disease stage, elevated serum lactate dehydrogenase, performance status, multiple extranodal involvement, high...
Indolent natural killer (NK) cell lymphoproliferative disorder of the gastrointestinal (GI) tract (iNKLPD) is a rare, recently recognised neoplasm. Most reported tumours are confined to GI tract, while small subset harbour JAK3 mutations. We collected four cases iNKLPD with goal adding additional information current knowledge this disease regarding clinicopathological, immunohistochemical and molecular features.Similar features including medium- large-sized lymphoid cells variable amounts...
The current standard of care for non-bulky diffuse large B-cell lymphoma (DLBCL) patients with an International Prognostic Index (IPI) 0 is four cycles rituximab plus cyclophosphamide, doxorubicin, vincristine and prednisone (R-CHOP) but whether the same efficacy can be achieved reduced chemotherapy regimen DLBCL IPI 1 remains unclear. This study compared versus six in low-risk negative interim positron emission tomography computed (PET-CT, Deauville 1-3), irrespective age other risk factors...
Visualizing spatial patterns of gene expression by optical microscopy at single-molecule resolution represents a long-standing challenge for imaging and molecular engineering technologies. In this study, we developed method visualizing mRNA with duplex capability using rolling circle amplification streptavidin-modified alkaline phosphatase (SA-ALP) to provide highly selective sensitive RNA detection. ALP-based detection provides comparable sensitivity specificity fluorescence-based in situ...
Abstract Background Marginal zone lymphomas (MZLs) comprise a diverse group of indolent lymphoproliferative disorders; however, some patients develop histologic transformation (HT) with rapid progression to aggressive lymphoma. Methods Forty‐three MZLs HT (HT‐MZLs), 535 MZLs, and 174 de novo diffuse large B‐cell (DLBCLs) without rearrangements MYC , BCL2 BCL6 were collected. Among these, 22 HT‐MZLs, 39 DLBCLs subjected 148‐gene targeted exome sequencing. The clinicopathologic features who...