A5063997421- Free Radicals and Antioxidants
- Synthesis and Biological Evaluation
- Ferrocene Chemistry and Applications
- Antioxidant Activity and Oxidative Stress
- Metal complexes synthesis and properties
- Synthesis and biological activity
- Synthesis of Organic Compounds
- Multicomponent Synthesis of Heterocycles
- Phytochemicals and Antioxidant Activities
- Bioactive Compounds and Antitumor Agents
- Genomics, phytochemicals, and oxidative stress
- Vitamin C and Antioxidants Research
- Ginseng Biological Effects and Applications
- Pharmacological Effects of Natural Compounds
- Photochemistry and Electron Transfer Studies
- Asymmetric Synthesis and Catalysis
- Biochemical effects in animals
- DNA and Nucleic Acid Chemistry
- Synthesis and Catalytic Reactions
- Zebrafish Biomedical Research Applications
- Synthesis of heterocyclic compounds
- Inorganic and Organometallic Chemistry
- Medicinal Plant Pharmacodynamics Research
- Physiological and biochemical adaptations
- Synthesis and Characterization of Heterocyclic Compounds
Jilin University
2015-2024
Anhui Normal University
2011-2024
Wuhan University of Technology
2014
Jilin Medical University
2012
State Key Laboratory of Supramolecular Structure and Materials
2007
Lanzhou University
1998-2000
Ginsenoside, the major active component in Panax ginseng, which has been used traditional Chinese medicine, contains a series of derivatives triterpene dammarane being attached by some sugar moieties. To clarify relationship between structure ginsenoside and its properties, 11 individual ginsenosides, along with central structures ginsenoside, protopanaxadiol protopanaxatriol, are 2,2'-azobis(2-amidinopropane hydrochloride) (AAPH) induced hemolysis human erythrocytes, good experimental model...
The aim of this work is to clarify the antioxidant abilities phenolic and enolic hydroxyl groups in curcumin. 1,7-Bis(4-benzyloxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione (BEC), 1,7-bis(4-hydroxy-3-methoxyphenyl)heptane-3,5-diol (OHC), 1,7-bis(4-hydroxy-3-methoxyphenyl)heptane-3,5-dione (THC), 1,7-bis(3,4-dihydroxyphenyl)-1,6-heptadiene-3,5-dione (BDC) are synthesized determine activities by using antiradical assays against 2,2′-diphenyl-1-picrylhydrazyl (DPPH) radical, galvinoxyl...
Two coumarin skeletons can form chromeno[3,4-c]chromene-6,7-dione by sharing with the C═C in lactone. The aim of present work was to explore antioxidant effectiveness coumarin-fused via six synthetic compounds containing hydroxyl and N,N-dimethylamino as functional groups. abilities quench 2,2′-azinobis(3-ethylbenzothiazoline-6-sulfonate) cationic radical (ABTS+•), 2,2′-diphenyl-1-picrylhydrazyl (DPPH), galvinoxyl revealed that rate constant for scavenging radicals related amount group...
Benzoyl and ferrocenoyl 3,4-dihydropyrimidin-2(1H)-ones (-thiones) (DHPMs) were synthesized in modest yields via catalyst-free solvent-free Biginelli condensation of 1-phenylbutane-1,3-dione or 1-ferrocenylbutane-1,3-dione, hydroxyl benzaldehyde, urea thiourea. This synthetic protocol revealed that catalysts may not be necessary for the self-assembling reaction. The radical-scavenging abilities obtained 11 DHPMs carried out by reacting with 2,2′-azinobis(3-ethylbenzothiazoline-6-sulfonate)...
The antioxidant effects of α-terpinene (α-TH) and γ-terpinene (γ-TH) on the oxidation methyl linoleate (LH), DNA, erythrocytes induced by 2,2′-azobis(2-amidinopropane hydrochloride) (AAPH) were investigated. results from DNA treated means chemical kinetic equations. It was found that either α- or γ-TH able to scavenge ∼0.4 radicals when they protected DNA. α-TH can trap ∼0.7 protecting ∼0.5 LH. ∼1.2 Therefore, effectiveness higher than α-TH. contained a nonconjugated diene, diene in...
Abstract The major objective was to measure the trolox (6‐hydroxy‐2,5,7,8‐tetramethylchroman‐2‐carboxylic acid) equivalent antioxidant capacity (TEAC) of carbazole derivatives (Ar 2 NHs) by means scavenging 2,2′‐diphenyl‐1‐picrylhydrazyl (DPPH) and 2,2′‐azinobis(3‐ethylbenzothiazoline‐6‐sulfonate) radical cation (ABTS +· ). Ar NHs included phenoxazine (PozNH), phenothiazine (PtzNH), iminostilbene (IsbNH) diphenylamine (DpaNH), TEAC trolox, α‐tocopherol (TocH), l ‐ascorbic acid (VC)...
Abstract The protective effects of 18 hydroxyl‐substituted Schiff bases (SchOHs) on the oxidative damage naked DNA induced by 2,2′‐azobis(2‐amidinopropane hydrochloride) (AAPH) were reported, in which SchOHs prepared condensing aromatic aldehydes and anilines. extent was followed measuring formation thiobarbituric acid reactive substance (TBARS). Some bearing only one hydroxyl group (prepared salicylic aldehyde) protected decreasing rate TBARS. Other inhibited oxidation for a period,...
As an abundant ingredient in coffee, chlorogenic acid (CGA) is a well-known antioxidant. Although some works have dealt with its radical-scavenging property, the present work investigated protective effects of CGA on oxidation DNA and hemolysis human erythrocytes induced by 2,2′-azobis(2-amidinopropane hydrochloride) (AAPH) means chemical kinetics. The inhibition period (tinh) derived from effect erythrocyte was proportional to concentration, tinh = (n/Ri)[CGA], where Ri refers...
Icariin (2-(4'-methoxylphenyl)-3-rhamnosido-5-hydroxyl-7-glucosido-8-(3'-methyl-2-butylenyl)-4-chromanone) is a flavonoid with rhamnose as ligand. It the major component in Herba epimedii, widely used for treatment of atherosclerosis and neuropathy Chinese traditional medicine, its antioxidative property has attracted much scientific interest. The objective this work to determine effect icariin against oxidative DNA damage induced by 2,2'-azobis(2-amidinopropane) dihydrochloride (AAPH). was...
Abstract Icariin (2-(4′-methoxyl phenyl)-3-rhamnosido-5-hydroxyl-7-glucosido-8-(3′-methyl-2-butylenyl)-4-chromanone) is the major component in Herba Epimedii used traditional Chinese medicine for treatment of atherosclerosis. This work focuses on antioxidative effect icariin free-radical-induced haemolysis human erythrocytes, which initial free radical derives from decomposition 2,2′-azobis(2-amidinopropane hydrochloride) (AAPH) at physiological temperature. To reveal structure-activity...