A5101464925- Platelet Disorders and Treatments
- Blood groups and transfusion
- Autoimmune Bullous Skin Diseases
- Chronic Lymphocytic Leukemia Research
- Acute Myeloid Leukemia Research
- Immunodeficiency and Autoimmune Disorders
- Lipid metabolism and disorders
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Cell Adhesion Molecules Research
- Renal Diseases and Glomerulopathies
- Cutaneous lymphoproliferative disorders research
- Fungal Infections and Studies
- Monoclonal and Polyclonal Antibodies Research
- Sarcoma Diagnosis and Treatment
- Balance, Gait, and Falls Prevention
- Blood properties and coagulation
- Multiple Myeloma Research and Treatments
- Immune Cell Function and Interaction
- CAR-T cell therapy research
- Diabetes Treatment and Management
- Immune cells in cancer
- Childhood Cancer Survivors' Quality of Life
- COVID-19 Clinical Research Studies
Qilu Hospital of Shandong University
2019-2025
Shandong University
2021-2022
Abstract We conducted a prospective, multicenter, randomized, controlled clinical trial to compare the efficacy and safety of high‐dose dexamethasone (HD‐DXM) plus recombinant human thrombopoietin (rhTPO), vs HD‐DXM alone in newly diagnosed adult immune thrombocytopenia (ITP) patients. Enrolled patients were randomly assigned receive DXM rhTPO or monotherapy. Another 4‐day course was repeated if response not achieved by day 10 both arms. One hundred arm 96 monotherapy included full analysis...
Summary Primary immune thrombocytopenia (ITP) is a haemorrhagic disorder with complex pathogenesis, wherein autoreactive B‐cell‐mediated platelet destruction plays crucial role. Bruton's tyrosine kinase (BTK) widely expressed and essential for cells. Several BTK inhibitors have been used clinically to treat haematological malignancies, while few studies are focusing on the regulatory role of in ITP. This study aims explore feasibility underlying mechanisms novel inhibitor orelabrutinib...
Cytotoxic T lymphocytes (CTLs)-mediated platelet destruction plays an important role in the pathogenesis of primary immune thrombocytopenia (ITP). The programmed cell death protein 1 (PD-1) signaling can turn off autoreactive cells and induce peripheral tolerance. Herein, we found that expression PD-1 its ligand PD-L1 on CD8 + from ITP patients was decreased. Activating pathway by PD-L1-Fc fusion inhibited CTLs-mediated vitro . promoter hypermethylation patients, resulting decreased...
Abstract Primary immune thrombocytopenia (ITP) is an autoantibody-mediated hemorrhagic disorder in which B cells play essential role. Previous studies have focused on peripheral blood (PB), but bone marrow (BM) not been well characterized. We aimed to explore the profile of B-cell subsets and their cytokine environments BM patients with ITP further clarify pathogenesis disease. subpopulations cytokine/chemokine receptors were detected by using flow cytometry. Plasma concentrations...
Abstract Primary immune thrombocytopenia (ITP) is an acquired autoimmune bleeding disorder. Monocytes and macrophages are the major cells involved in autoantibody-mediated platelet clearance ITP. In present study, we found increased percentages of peripheral blood proinflammatory CD16+ monocytes elevated frequencies splenic tumor necrosis factor-α (TNF-α)-expressing ITP patients compared with healthy controls. Concurrently, observed TNF-α secretion plasma as well higher mRNA expression total...
Background: Antinuclear antibodies (ANAs) can be detected in about 30% of patients with primary immune thrombocytopenia (ITP), yet their relationship treatment response to rituximab remains elusive.Methods: we retrospectively reviewed the clinical records hospitalized adult ITP who were treated from three medical centers across China. Rituximab was given intravenously at 100 mg weekly for 4 weeks, or a single dose 375 mg/m2. All included had ANAs tested before treatment.Results: A total 287...
Acute myeloid leukemia (AML) is a heterogeneous hematological malignancy, whose immunological mechanisms are still partially uncovered. Regulatory B cells (Bregs) and CD4+ regulatory T (Tregs) subgroups of immunoregulatory involved in modulating autoimmunity, inflammation, transplantation reactions. Herein, by studying the number function Breg Treg cell subsets patients with AML, we explored their potential role pathogenesis AML. Newly diagnosed AML patients, complete remission, healthy...
Summary This retrospective study aimed to evaluate the relationship between plasma autoantibody species and rhTPO response in adult ITP patients who failed first‐line treatments. Plasma anti‐glycoprotein (GP) IIb/IIIa anti‐GPIb/IX autoantibodies were detected 47·2% 40·6% of 123 patients, respectively. Overall rate treatment without was significantly higher than with (82·2% vs. 60·0%, P = 0·006). By contrast, no statistical difference observed or anti‐GPIIb/IIIa (74·1% 72·3%, 0·819)....
Immune thrombocytopenia (ITP) is an autoimmune hemorrhagic disease characterized by low platelet count and bleeding manifestations. However, some patients also suffered from atherosclerosis or even infarction. Apart activated platelets, lipid metabolism takes a large part in the formation of metabolic syndrome. The state ITP still unknown.We retrospectively reviewed 302 hospitalized our cohort, comparing their blood lipids, symptoms, diseases treatment responses.We found high proportion...
Summary Immune thrombocytopenia (ITP) is an autoimmune haemorrhagic disease, in which the overactivation of T cells crucial pathogenesis. Atorvastatin (AT), a lipid‐lowering medicine, has shown promising immunomodulatory effects certain inflammatory conditions. However, immunoregulatory role AT ITP remains elusive. To investigate effect treatment ITP, cluster differentiation 4 (CD4) + were isolated from patients with and cultured different dosages AT. We found that significantly inhibited...
Summary Corticosteroids are the standard first‐line treatment for primary immune thrombocytopenia (ITP), with a high initial response but unsatisfactory sustained (SR). Additionally, corticosteroids usually lead to hyperglycaemia especially in patients pre‐existing type 2 diabetes mellitus (T2DM). Besides reducing blood glucose levels, metformin was found have immunomodulatory effects. We hereby conducted multicentre propensity score matching analysis of plus versus newly diagnosed ITP T2DM....
Background: Immune thrombocytopenia is an autoimmune hemorrhagic disease characterized by low platelet count and bleeding manifestations. However, some patients also suffered from atherosclerosis or even infarction. Apart activated platelets, lipid metabolism takes a large part in the formation of metabolic syndrome. The state ITP still unknown.Methods: We retrospectively reviewed 302 hospitalized our cohort, comparing their blood lipids, symptoms, diseases treatment responses.Results: found...