A5103833482- Prenatal Screening and Diagnostics
- Cancer Cells and Metastasis
- Neural dynamics and brain function
- Acute Myeloid Leukemia Research
- Flavonoids in Medical Research
- Fetal and Pediatric Neurological Disorders
- SARS-CoV-2 and COVID-19 Research
- Organ Transplantation Techniques and Outcomes
- Influenza Virus Research Studies
- vaccines and immunoinformatics approaches
- Long-Term Effects of COVID-19
- Protein Degradation and Inhibitors
- Respiratory viral infections research
- Brucella: diagnosis, epidemiology, treatment
- Syphilis Diagnosis and Treatment
- Sleep and Wakefulness Research
- Advanced Breast Cancer Therapies
- Glutathione Transferases and Polymorphisms
- Renal and related cancers
- Nanoplatforms for cancer theranostics
- Venous Thromboembolism Diagnosis and Management
- Gastric Cancer Management and Outcomes
- Chromatography in Natural Products
- Vascular Tumors and Angiosarcomas
- Neurosurgical Procedures and Complications
Children's Hospital of Capital Institute of Pediatrics
2025
University of Electronic Science and Technology of China
2025
Shandong Provincial Hospital
2024
Shandong First Medical University
2024
Kunming Institute of Zoology
2002-2024
Chinese Academy of Sciences
2002-2024
Shanxi Cardiovascular Hospital
2024
Ya'an Polytechnic College
2024
Affiliated Hospital of Qingdao University
2014-2023
Qingdao University
2014-2023
The aim of this prospective study was to assess the dynamic changes persisting symptoms among children aged 6-18 years during 1-2 months after Omicron infection based on modified SBQ-LC in Tongzhou cohort, Beijing. This includes 4 serial surveys performed within January 7-9, 14-16, 21-23, and February 12-14 2023, respectively. prediction age survey for eight domains Rasch 0-100 linear score undertaken by generalized additive mixed model. Total 1,536 (median age: 13 years, boys: 49.9%) had...
Background As a member of the cysteine protease family, cathepsin S has been implicated in pathogenesis various diseases, including Alzheimer's disease (AD), primarily by promoting inflammation. Objective Current evidence regarding role comes from animal studies. This study aims to explore clinical relevance AD. Methods In cohort older adults aged 60 or above with memory complaints, we examined baseline plasma levels and assessed their association cognitive decline biomarkers...
Abstract Rapid determination of the antigenicity influenza A virus could help identify antigenic variants in time. Currently, there is a lack computational models for predicting some common hemagglutinin (HA) subtypes viruses. By means sequence analysis, we demonstrate here that multiple HA undergo similar mutation patterns HA1 protein (the immunogenic part HA). Further analysis on variation H1N1, H3N2 and H5N1 showed amino acid residues’ contribution to highly differed these subtypes, while...
Cell division in eukaryotes is a highly regulated process that critical to the life of cell. Dysregulated cell proliferation, often driven by anomalies Cyclin-dependent kinase (CDK) activation, key pathological mechanism cancer. Recently, selective CDK4/6 inhibitors have shown clinical success, particularly treating advanced-stage estrogen receptor (ER)-positive and human epidermal growth factor 2 (HER2)-negative breast This review provides an in-depth analysis action recent advancements...
Circulating tumor cell (CTC)-based patient-derived cells are ideal models for investigating the molecular basis of cancer. However, rarity and heterogeneity CTCs as well difficulties primary culture limit their practical application. Establishing efficient in vitro methods functionally characterizing is essential cancer studies. To this end, we developed an experimental protocol isolation, expansion, identification breast CTCs.The CTC-3 line was established from peripheral blood a patient. A...
Dynamically monitoring the clonal evolution of lung cancer and performing molecular analyses on tumor cells are challenging but necessary tasks to adjust therapeutic interventions evaluate treatment efficacy. Circulating (CTCs), as a "liquid biopsy", may offer an auxiliary tool identify phenotypic transformation solid tumors at primary or metastatic sites uncover their corresponding variation. Herein, we developed aptamer-modified PEG-PLGA-nanofiber (PPN) microfluidic system optimized for...
Abstract Long‐range thalamocortical communication is central to anesthesia‐induced loss of consciousness and its reversal. However, isolating the specific neural networks connecting thalamic nuclei with various cortical regions for state‐specific anesthesia regulation challenging, biological underpinnings still largely unknown. Here, simultaneous electroencephalogram‐fuctional magnetic resonance imaging (EEG‐fMRI) deep brain stimulation are applied intralaminar thalamus in macaques under...
Cystic fibrosis (CF) is caused by mutations in the cystic transmembrane conductance regulator ( CFTR ) gene. CF cells and tissues exhibit various mitochondrial abnormalities. However, underlying molecular mechanisms remain elusive. Here, we examined through which regulates Bcl‐2 family proteins, turn regulate permeabilization of outer membrane. Notably, inhibition activated Bax Bad, but inhibited Bcl‐2. Moreover, degradation phosphorylated extracellular signal‐regulated kinase 1/2 (ERK1/2)...
Objectives Multiple myeloma (MM) is a class of malignant plasma cell diseases. An increasing application autologous stem transplantation (ASCT) and anti-myeloma agents represented by proteasome inhibitors (PIs) has improved the response rates survival MM patients. Patients progressing within 12 months were recently categorized with functional high-risk (FHR), which could not be clarified existing genetic risk factors, poor outcomes. Our study aimed to investigate clinical indices related FHR...
To prevent congenital syphilis, the Centers for Disease Control and Prevention professional organizations recommend universal prenatal syphilis screening. State-level or larger-scale evaluations of adherence to these guidelines have relied on administrative data. We measured screening rates in Indiana women with Medicaid coverage also used electronic medical records examine completeness claims data.In statewide data, diagnosis procedure codes were identify who delivered an infant between...
Tuberous sclerosis complex (TSC) is an autosomal dominant disorder characterized by hamartomas in any organ systems. Mutations the TSC1 or TSC2 gene lead to dysfunction of hamartin tuberin proteins, which cause tuberous complex. We describe clinical characteristics patients from a Chinese family with and analyze functional consequences their causal genetic mutations. A novel heterozygous mutation (c.3610G > A) at last nucleotide exon 29 was identified. On protein level, this variant presumed...
To investigate the effect of Baicalin on proliferation and pyroptosis diffuse large B-cell lymphoma cell line DB its mechanism.DB cells were treated with baicalin at different concentrations (0, 5, 10, 20, 40 μmol/L). Cell was detected by CCK-8 assay half maximal inhibitory concentration (IC50) calculated. The morphology observed under an inverted microscope, integrity membrane verified LDH content release assay, expressions pyroptosis-related mRNA protein (NLRP3, GSDMD, GSDME, N-GSDMD,...
To determine the biological activity of ellagic acid extracted from gallnut against nasopharyngeal carcinoma and its molecular mechanism.Nasopharyngeal 5-8F cells were treated with 2, 4, 6 μg/mL for 48 h in vitro. The cell proliferation apoptosis analyzed by MTT Hoechst33258 stain. cycle protein expression measured flow cytometry Western blot.Ellagic inhibited cells. inhibition rates (29.35±4.95)%, (53.32 ±4.44)% ( 61.75 + 6.93)%, respectively, significant difference control group (P<0.01)....
To explore the cause of inconsistency between results trisomy 7 by expanded non-invasive prenatal testing (NIPT-PLUS) and 18 diagnosis.
The aim of this study was to elucidate the critical role autophagy-related gene aggregation in gastric cancer tumor microenvironment cells and investigate their major roles cellular functions. In particular, expression these genes tumor-associated fibroblast subtypes scrutinized an attempt explain cell-subpopulation-specific cell–cell communication regulation study, single-cell RNA sequencing data were first analyzed multiple steps, including preprocessing, cell clustering, classification....
Clinical application of CTC in gestational choriocarcinoma.