A5083418260- Gestational Trophoblastic Disease Studies
- Retinal Imaging and Analysis
- Ophthalmology and Visual Health Research
- Retinal Diseases and Treatments
- Prenatal Screening and Diagnostics
- Congenital Diaphragmatic Hernia Studies
- Ophthalmology and Visual Impairment Studies
- Thyroid Cancer Diagnosis and Treatment
- Anatomy and Medical Technology
- Biofuel production and bioconversion
- Ultrasound and Hyperthermia Applications
- Spectroscopy Techniques in Biomedical and Chemical Research
- Renal and related cancers
- Prostate Cancer Diagnosis and Treatment
- Innovative Human-Technology Interaction
- Biomedical Text Mining and Ontologies
- Radiomics and Machine Learning in Medical Imaging
- Virtual Reality Applications and Impacts
- Urban Green Space and Health
- Retinal and Optic Conditions
- Protease and Inhibitor Mechanisms
- Lung Cancer Treatments and Mutations
- Fungal and yeast genetics research
- Peptidase Inhibition and Analysis
- Corneal surgery and disorders
University of Toronto
2016-2022
Hospital for Sick Children
2021
Western University of Health Sciences
2021
Carnegie Mellon University
2020
University of Calgary
2017-2019
Calgary Laboratory Services
2019
A global genetic suppression network The background of an organism can influence the overall effects new variants. Some mutations amplify a deleterious phenotype, whereas others suppress it. Starting with literature survey and expanding into genomewide assay, van Leeuwen et al. generated large-scale in yeast. data set reveals general properties that be used to predict interactions. Furthermore, study provides template for extending studies other genes or more complex organisms. Science ,...
Prostate cancer is the second leading cause of death in men. Its current treatment includes various physical and chemical approaches for localized advanced prostate [e.g. metastatic castrate resistant (mCRPC)]. Although many new drugs are now available cancer, none suitable local that can reduce adverse effects often associated with treatment. Of approved by FDA mCRPC, best mean improvement overall survival only about 4.8 months. Therefore, there a need improved especially drug-resistant...
Gestational choriocarcinoma (GC) is a highly aggressive tumor. In our study, we systematically investigated EpCAM/CD147 expression characteristics in patients with GC and assessed the role of circulating tumor cells (CTCs) predicting chemotherapy response disease progression. tissues were positive for either epithelial cellular adhesion molecule (EpCAM) or CD147, all samples exhibited strong human chorionic gonadotropin (HCG) expression. Among recruited (n = 115), 103 had at least 1 CTC...
Differentiation of benign and malignant thyroid nodules is crucial for clinical management. Here, we explored the efficacy next‑generation sequencing (NGS) in predicting classification lymph node metastasis status, simultaneously compared results with ultrasound (US). Thyroline was designed to detect 15 target gene mutations 2 fusions 98 formalin‑fixed, paraffin‑embedded (FFPE) tissues, including those from 82 cancer (TC) patients 16 nodules. BRAF were found 57.69% papillary (PTC) cases,...
Circulating tumor cells (CTCs) detection, an approach considered to be "liquid biopsy", is a potential alternative method in clinical use for early diagnosis of solid progression.In this study, we developed poly (lactic-co-glycolic acid) (PLGA) - nanofiber (PN)-NanoVelcro chip as efficient device simple and rapid capture CTCs from peripheral blood. We evaluated the performance by assessing efficiency purity. Single CTC was isolated via laser microdissection system subsequent genetic...
Abstract: Lung adenocarcinoma (LADC) is among the most malignant cancers that frequently develops micrometastases even in early stages of disease. Circulating tumor cell (CTC) number, matrix metalloproteinase (MMP) 7, and MMP9 show great prospects as predictive biomarkers many tumors. However, interactions between these molecular basis their roles metastasis prognosis LADC remain unclear. The present study revealed an elevated CTC count overexpression MMP7 correlate with clinical progression...
There has been a great deal of research regarding the ways that people conceptualize and interact with places they call "home." This work extended to virtual reality primarily in context design tools. Here, we explore idea hybrid virtual-physical home uses space supplement an existing physical home. We identify variation spatial place attachment homes. A user study (N = 25) revealed expectations needs these groups have for spaces, including security, familiarity, community. prototyped...
Clinical application of CTC in gestational choriocarcinoma.
Background: To investigate whether circulating tumor cells (CTCs) are detectable in patients with gestational choriocarcinoma (GC) and evaluate the prognostic value of CTC enumeration.