A5101414021- Platelet Disorders and Treatments
- Blood groups and transfusion
- Chronic Lymphocytic Leukemia Research
- Cell Adhesion Molecules Research
- Immune Cell Function and Interaction
- Blood properties and coagulation
- Autoimmune Bullous Skin Diseases
- Lipid metabolism and disorders
- Endometriosis Research and Treatment
- Vitamin D Research Studies
- Hereditary Neurological Disorders
- Musculoskeletal synovial abnormalities and treatments
- Sleep and related disorders
- Plant Toxicity and Pharmacological Properties
- Pregnancy-related medical research
- Tryptophan and brain disorders
- Inflammatory Bowel Disease
- Immune Response and Inflammation
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Peripheral Neuropathies and Disorders
- Psoriasis: Treatment and Pathogenesis
- Heparin-Induced Thrombocytopenia and Thrombosis
- Antiplatelet Therapy and Cardiovascular Diseases
- IL-33, ST2, and ILC Pathways
- PI3K/AKT/mTOR signaling in cancer
Ningxia Medical University General Hospital
2024
Ningxia Medical University
2022-2024
Soochow University
2024
Stanford University
2022-2023
Shandong First Medical University
2023
Ningbo University
2022
Ningbo Kangning Hospital
2022
Qilu Hospital of Shandong University
2016-2022
Beijing Technology and Business University
2022
Harbin Medical University
2017
In addition to antiplatelet autoantibodies, CD8(+) cytotoxic T lymphocytes (CTLs) play an important role in the increased platelet destruction immune thrombocytopenia (ITP). Recent studies have highlighted that desialylation leads clearance via hepatocyte asialoglycoprotein receptors (ASGPRs). Whether cells induce ITP remains unclear. Here, we investigated cytotoxicity of towards platelets and ITP. We found fresh was significantly higher patients with positive than those without controls....
Immune thrombocytopenia (ITP) is traditionally considered an antibody-mediated disease. However, a number of features suggest alternative mechanisms platelet destruction. In this study, we use multi-dimensional approach to explore the role cytotoxic CD8+ T cells in ITP. We characterised patients with ITP and compared them age-matched controls using immunophenotyping, next-generation sequencing cell receptor (TCR) genes, single-cell RNA sequencing, functional assays. found that adults chronic...
Cytotoxic T lymphocytes (CTLs)-mediated platelet destruction plays an important role in the pathogenesis of primary immune thrombocytopenia (ITP). The programmed cell death protein 1 (PD-1) signaling can turn off autoreactive cells and induce peripheral tolerance. Herein, we found that expression PD-1 its ligand PD-L1 on CD8 + from ITP patients was decreased. Activating pathway by PD-L1-Fc fusion inhibited CTLs-mediated vitro . promoter hypermethylation patients, resulting decreased...
Abstract Primary immune thrombocytopenia (ITP) is an autoantibody-mediated hemorrhagic disorder in which B cells play essential role. Previous studies have focused on peripheral blood (PB), but bone marrow (BM) not been well characterized. We aimed to explore the profile of B-cell subsets and their cytokine environments BM patients with ITP further clarify pathogenesis disease. subpopulations cytokine/chemokine receptors were detected by using flow cytometry. Plasma concentrations...
Abstract Immune thrombocytopenia (ITP) is an acquired autoimmune disease characterized by immune mediated decrease in platelet number. Disturbance of CD4 + T‐cell homeostasis with simultaneous CD25 Foxp3 regulatory T cells (Tregs) as well unrestricted proliferation and activation peripheral effector underpin the pathophysiology ITP. Indirubin active ingredient a traditional Chinese herb called Indigofera tinctoria L. which clinically used for treatment ITP patients. Whether indirubin targets...
To evaluate whether the serum thrombopoietin levels in pregnancy-associated immune thrombocytopenia (ITP) differ from those gestational thrombocytopenia, and reveal possibility of serving as a marker for differential diagnosis. Serum concentration was determined ITP pregnancy (n = 35), 31), healthy 32), age-matched nonpregnant 32) controls 35) by ELISA. The level (1283 ± 646 pg/mL) significantly higher than (187 64 (P < 0.01), although platelet counts these two disorders may overlap....
Summary Exosomes are released into extracellular fluids and have emerged as vital biological mediators in autoimmune diseases. Plasma‐derived exosomes been reported to take part the pathogenesis of primary immune thrombocytopenia (ITP), but protein miRNA cargoes not entirely elucidated. Via proteomic analysis RNA sequencing on plasma‐derived from ITP patients healthy controls, we found one upregulated exosomal (apolipoprotein E, ApoE), six downregulated miRNAs (miR‐584‐5p, miR‐4433a‐5p,...
Primary immune thrombocytopenia (ITP) is the most common acquired autoimmune bleeding disorder. Abnormally increased levels of High Mobility Group Box 1 (HMGB1) protein associate with and therapeutic outcome in ITP. Previous studies proposed that a natural inhibitor HMGB1, 18β-glycyrrhetinic acid (18β-GA), could be used for its anti-inflammatory immune-modulatory effects, although ability to correct balance ITP unclear. In this study, we showed plasma HMGB1 correlated negatively platelet...
Chronic prostatitis is a common urological disease. The etiology of this disease and effective therapy for its treatment are yet to be elucidated. We investigated the functions XLQ® in chronic nonbacterial using complete Freund's adjuvant-induced rat model. Prostates blood samples were collected further evaluation after oral gavage with XLQ ® or vehicle 4 weeks. results showed that significantly decreased prostate index, ameliorated histopathologic changes, reduced CD3+ CD45+ cell...
Depression, a psychiatric disorder with significant morbidity and mortality, has complex etiology. Recent advances in microbiome research have highlighted the potential role of gut microbiota depression pathogenesis. This study utilized shotgun metagenomic sequencing to compare fecal 28 patients 26 healthy individuals. Significant differences composition were observed between two groups. We generated 350 non-redundant high-quality metagenome-assembled Genomes (MAGs) by binning conducted...
Cationic antimicrobial peptides, produced by nonribosomal peptide synthetases (NRPSs), have received great attention in different applications, including as biocontrol and agents against foodborne pathogenic bacteria. Also, Brevibacillus spp. is a competent microorganism to produce cationic peptides yet has little attention. Herein, laterosporus S62-9 genome mining revealed an integrated synthetase system that synthesized brevilaterin. Combining biochemical analysis with bioinformatics...
Cyclic thrombocytopenia (CTP) is a rare disease of periodic platelet count oscillations. The pathogenesis CTP remains elusive. To study the underlying pathophysiology and genetic cellular associations with CTP, we applied systems biology approaches to 2 patients stable cycling reciprocal thrombopoietin (TPO) at multiple time points through cycles. Blood transcriptome analysis revealed platelet-specific genes, which are in parallel precede oscillation, indicating that cyclical production...
Summary Immune thrombocytopenia (ITP) is an autoimmune haemorrhagic disease, in which the overactivation of T cells crucial pathogenesis. Atorvastatin (AT), a lipid‐lowering medicine, has shown promising immunomodulatory effects certain inflammatory conditions. However, immunoregulatory role AT ITP remains elusive. To investigate effect treatment ITP, cluster differentiation 4 (CD4) + were isolated from patients with and cultured different dosages AT. We found that significantly inhibited...
This study aimed to explore the potential mechanisms of exercise prevent pelvic organ prolapse (POP) and search for diagnostic indictors POP.We used two clinical POP datasets with patients' information (GSE12852 GSE53868), a dataset consisting altered microRNA expression in circulating blood after (GSE69717) bioinformatic analysis analysis, while series cellular experiments were conducted preliminary mechanical validation.Our results show that AXUD1 is highly expressed smooth muscle ovary...
Objective: To identify the prevalence of sleep problems in children with autism spectrum disorder (ASD) and to explore association main melatonin metabolite, 6-sulfatoxymelatonin (6-SM). Method: This was a prospective case-control study. Children ASD were recruited from Child Development Behavioral Research Center (CDBRC) Harbin Medical University Special Education School October 2015 April 2017 (ASD group) . Healthy controls selected five kindergartens one primary school by stratified...
The purpose of this research is to determine the prognosis patients treated with transumbilical single-port laparoscopic surgery for acute pelvic inflammatory illness. Postoperative data on 129 illness were obtained retrospectively. It was observed that shorter time required postoperative leukocyte recovery normal, pain and diet recovery, as well hospital stay, in such individuals. CIBERSORT used examine patient from GEO. most significant difference between normal groups neutrophil content....