A5100436036- Parasites and Host Interactions
- Parasite Biology and Host Interactions
- Parasitic Diseases Research and Treatment
- SARS-CoV-2 and COVID-19 Research
- Acute Myeloid Leukemia Research
- Platelet Disorders and Treatments
- Hematopoietic Stem Cell Transplantation
- Tuberculosis Research and Epidemiology
- Research on Leishmaniasis Studies
- HIV/AIDS Research and Interventions
- Mycobacterium research and diagnosis
- Chronic Lymphocytic Leukemia Research
- Viral gastroenteritis research and epidemiology
- Blood groups and transfusion
- Trypanosoma species research and implications
- HIV Research and Treatment
- Autoimmune and Inflammatory Disorders Research
- Monoclonal and Polyclonal Antibodies Research
- COVID-19 Clinical Research Studies
- Autoimmune Bullous Skin Diseases
- Hematological disorders and diagnostics
- Pneumonia and Respiratory Infections
- Chronic Myeloid Leukemia Treatments
- SARS-CoV-2 detection and testing
- Ferroptosis and cancer prognosis
Nanjing University of Chinese Medicine
2023-2025
Chinese Center For Disease Control and Prevention
2011-2024
Children's Hospital of Philadelphia
2024
Drexel University
2024
Capital Medical University
2015-2024
Shenzhen Children's Hospital
2024
Beijing Friendship Hospital
2012-2024
Chinese Academy of Sciences
2020-2024
Xinjiang Medical University
2012-2024
Guangxi Medical University
2024
The cost-effectiveness of early antiretroviral therapy (ART) in persons infected with human immunodeficiency virus (HIV) serodiscordant couples is not known. Using a computer simulation the progression HIV infection and data from Prevention Trials Network 052 study, we projected ART for such persons.
According to epidemiological and experimental data, high individual dietary antioxidant intake is correlated with reduced cancer risk. The correlations between combined antioxidants the risk of all-cause cardiovascular mortality remain unclear. Consequently, this study focused on evaluating correlation food-derived Composite Dietary Antioxidant Index (CDAI) mortality.Two years data collected from participants aged ≥20 were included in prospective cohort study, which was obtained US National...
Abstract Monoclonal antibodies (mAbs) targeting the SARS-CoV-2 receptor-binding domain (RBD) showed high efficacy in prevention and treatment of COVID-19. However, rapid evolution has rendered all clinically authorized mAbs ineffective continues to stymie development next-generation mAbs. Consequently, ability identify broadly neutralizing (bnAbs) that neutralize both current future variants is critical for successful antibody therapeutic development, especially newly emerged viruses when no...
US guidelines recommend at least annual HIV testing for those risk. This analysis assessed frequency and correlates of infrequent late diagnosis among black men who have sex with (BMSM).
In this paper, two new brackish-water species of Macrostomum (M. shenzhenensis n. sp. and M qiaochengensis sp.) collected from the artificial lake in Overseas Chinese Town mangrove wetland, are described based on morphology penis stylet a molecular phylogenetic analysis. M. has an elongate, narrow with torus-shaped distal wall thickening, while hook-like pointed end. Both 18S 28S rDNA analyses support establishments these species. Finally, categorization sperm stylet, as well other...
Mutations and transient conformational movements of the receptor binding domain (RBD) that make neutralizing epitopes momentarily unavailable present immune escape routes for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). To mitigate viral escape, we developed a cocktail antibodies (NAbs) targeting located on different domains spike (S) protein. Screening library monoclonal generated from peripheral blood mononuclear cells COVID-19 convalescent patients yielded potent NAbs,...
The purpose of this cross-sectional observational study was to identify ethnic differences in body composition and obesity-related risk factors between Chinese white males living China. 115 114 male pilots aged 28-63 years were recruited. Fasting weight, height blood pressure measured following standard procedures. Whole-body segmental using an 8-contact electrode bioimpedance analysis (BIA) system. serum glucose, fasting plasma total cholesterol (TC), high-density lipoprotein (HDL)...
Background Our previous studies showed that Trichinella spiralis paramyosin (TsPmy) is an immunomodulatory protein inhibits complement C1q and C8/C9 to evade host attack. Vaccination with recombinant TsPmy induced protective immunity against T. larval challenge. Due the difficulty in producing as a soluble protein, we prepared DNA vaccine alternative approach order elicit robust infection. Methods Findings The full-length coding was cloned into eukaryotic expression plasmid pVAX1,...
Abstract We conducted a prospective, multicenter, randomized, controlled clinical trial to compare the efficacy and safety of high‐dose dexamethasone (HD‐DXM) plus recombinant human thrombopoietin (rhTPO), vs HD‐DXM alone in newly diagnosed adult immune thrombocytopenia (ITP) patients. Enrolled patients were randomly assigned receive DXM rhTPO or monotherapy. Another 4‐day course was repeated if response not achieved by day 10 both arms. One hundred arm 96 monotherapy included full analysis...
Stereo-seq is the state-of-the-art technique, which allows capturing of spatial transcriptomic data at sub-cellular resolution and in large scale view. FFPE technique recently launched with capability to obtain spatially resolved gene expression tissue sections. However, omic information limited transcriptome. To delineate molecular hierarchy from transcriptome phenome, we present protocol that implements nine-plex immunofluorescence staining detection transcriptomics one section (short for...
MicroRNAs (miRNAs) were reported to be involved in the development of clear cell renal carcinoma (ccRCC). However, study on miRNAs ccRCC is far from complete. The present identified which could act as potential novel prognostic markers for ccRCC, and analyzed its possible mechanism. We found that miR-19a correlated with poor prognosis patients via promoting proliferation suppressing PTEN/SMAD4 expression. Both microarray screening result TCGA KIRC dataset analysis showed was significantly...
Helminth parasites release extracellular vesicles which interact with the surrounding host tissues, mediating host–parasite communication and other fundamental processes of parasitism. As such, vesicle proteins present attractive targets for development novel intervention strategies to control these diseases they cause. Herein, we describe first proteomic analysis by LC-MS/MS two types (exosome-like, 120 k pellet microvesicle-like, 15 vesicles) from adult Schistosoma haematobium worms. A...
Biochemical recurrence (BCR) occurs in up to 27% of patients after radical prostatectomy (RP) and often compromises oncologic survival. To determine whether imaging signatures on clinical prostate magnetic resonance (MRI) could noninvasively characterize biochemical optimize treatment. We retrospectively enrolled 485 underwent RP from 2010 2017 three institutions. Quantitative interpretable features were extracted T2 delineated tumors. Deep learning-based survival analysis was then applied...
Helminths and helminth-derived products hold promise for treating joint bone erosion in rheumatoid arthritis (RA). However, the mechanisms of helminths ameliorating osteoclastic destruction are incompletely understood. Here, we report that Trichinella spiralis infection or treatment with excreted/secreted T. muscle larvae (MES) attenuated osteoclastogenesis mice collage-induced (CIA) through inhibiting M1 monocyte/macrophage polarization production M1-related proinflammatory cytokines. In...
Abstract Precision therapy for clear cell renal carcinoma (cc RCC ) requires molecular biomarkers ascertaining disease prognosis. In this study, we performed integrated proteomic and transcriptomic screening in all four tumour‐node‐metastasis stages of cc adjacent normal tissues ( n = 18) to investigate differentially expressed genes. Most identified genes revealed a strong association with transforming growth factor‐β level the epithelial‐to‐mesenchymal transition process. Of them, Serpin...