A5030797623- SARS-CoV-2 and COVID-19 Research
- Animal Virus Infections Studies
- Alzheimer's disease research and treatments
- Bacillus and Francisella bacterial research
- Viral gastroenteritis research and epidemiology
- Tryptophan and brain disorders
- Plant-derived Lignans Synthesis and Bioactivity
- COVID-19 Clinical Research Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- vaccines and immunoinformatics approaches
- Respiratory viral infections research
- Cholinesterase and Neurodegenerative Diseases
- Digital Mental Health Interventions
- Immune Cell Function and Interaction
- Covalent Organic Framework Applications
- Mind wandering and attention
- COVID-19 Impact on Reproduction
- Monoclonal and Polyclonal Antibodies Research
- Advanced Photocatalysis Techniques
- Hepatitis C virus research
- Parkinson's Disease Mechanisms and Treatments
- Metal-Organic Frameworks: Synthesis and Applications
- Impact of Technology on Adolescents
- Ginger and Zingiberaceae research
- Protein purification and stability
Institute of Biophysics
2020-2024
Chinese Academy of Sciences
2020-2024
University of Chinese Academy of Sciences
2021-2022
China University of Geosciences (Beijing)
2021
University of Washington
2021
Shenyang Pharmaceutical University
2017-2019
Chang Gung Memorial Hospital
1994
The SARS-CoV-2 Omicron variant with increased fitness is spreading rapidly worldwide. Analysis of cryo-EM structures the spike (S) from reveals amino acid substitutions forging interactions that stably maintain an active conformation for receptor recognition. relatively more compact domain organization confers improved stability and enhances attachment but compromises efficiency viral fusion step. Alterations in local conformation, charge, hydrophobic microenvironments underpin modulation...
Abstract Omicron (B.1.1.529), the most heavily mutated SARS-CoV-2 variant so far, is highly resistant to neutralizing antibodies, raising concerns about effectiveness of antibody therapies and vaccines 1,2 . Here we examined whether sera from individuals who received two or three doses inactivated vaccine could neutralize authentic Omicron. The seroconversion rates antibodies were 3.3% (2 out 60) 95% (57 for had 2 3 vaccine, respectively. For recipients doses, geometric mean neutralization...
Abstract Emergence of variants concern (VOC) with altered antigenic structures and waning humoral immunity to SARS-CoV-2 are harbingers a long pandemic. Administration third dose an inactivated virus vaccine can boost the immune response. Here, we have dissected immunogenic profiles antibodies from 3-dose vaccinees, 2-dose vaccinees convalescents. Better neutralization breadth VOCs, expeditious recall long-lasting response bolster in warding off COVID-19. Analysis 171 complex neutralizing...
Abstract New threats posed by the emerging circulating variants of SARS-CoV-2 highlight need to find conserved neutralizing epitopes for therapeutic antibodies and efficient vaccine design. Here, we identified a receptor-binding domain (RBD)-binding antibody, XG014, which potently neutralizes β-coronavirus lineage B (β-CoV-B), including SARS-CoV-2, its variants, SARS-CoV bat SARSr-CoV WIV1. Interestingly, antibody family members competing with XG014 binding show reduced levels...
Summary The SARS-CoV-2 Omicron with increased fitness is spreading rapidly worldwide. Analysis of cryo-EM structures the Spike (S) from reveals amino acid substitutions forging new interactions that stably maintain an “active” conformation for receptor recognition. relatively more compact domain organization confers improved stability and enhances attachment but compromises efficiency viral fusion step. Alterations in local conformation, charge hydrophobic microenvironments underpin...
In the attention economy, video apps employ design mechanisms like autoplay that exploit psychological vulnerabilities to maximize watch time. Consequently, many people feel a lack of agency over their app use, which is linked negative life effects such as loss sleep. Prior research has innovated external police multiple apps, lockout timers. this work, we shift focus how internal an can support user agency, taking popular YouTube mobile test case. From survey 120 U.S. users, find and...
Crude extract from Escherichia coli which expressed a recombinant protein containing amino acids 2 to 127 of the hepatitis C virus (HCV) core was used detect antibody against HCV (anti-HCc). After electrophoretic separation proteins extract, Western blot (immunoblot) analysis performed with serum samples. This method compared commercially available second-generation enzyme immunoassay (EIA) employed synthetic peptides corresponding highly antigenic segments both structural and nonstructural...
Abstract Omicron, the most heavily mutated SARS-CoV-2 variant so far, is highly resistant to neutralizing antibodies, raising unprecedented concerns about effectiveness of antibody therapies and vaccines. We examined whether sera from individuals who received two or three doses inactivated vaccine, could neutralize authentic Omicron. The seroconversion rates antibodies were 3.3% (2/60) 95% (57/60) for 2- 3-dose vaccinees, respectively. For three-dose recipients, geometric mean neutralization...