A5101866124- Viral gastroenteritis research and epidemiology
- SARS-CoV-2 and COVID-19 Research
- Hepatitis B Virus Studies
- Influenza Virus Research Studies
- interferon and immune responses
- Monoclonal and Polyclonal Antibodies Research
- Hepatitis C virus research
- Endoplasmic Reticulum Stress and Disease
- COVID-19 Clinical Research Studies
- Vibrio bacteria research studies
- Viral Infections and Immunology Research
- HIV/AIDS Research and Interventions
Shanghai Public Health Clinical Center
2025
Fudan University
2021-2024
Fifth Hospital In Wuhan
2021
Shanghai Medical College of Fudan University
2021
Wuhan University
2021
Chongqing Medical University
2021
Rongsheng Petrochemical (China)
2001
University of Maryland, Baltimore
1992-1994
Tongji University
1994
Abstract New threats posed by the emerging circulating variants of SARS-CoV-2 highlight need to find conserved neutralizing epitopes for therapeutic antibodies and efficient vaccine design. Here, we identified a receptor-binding domain (RBD)-binding antibody, XG014, which potently neutralizes β-coronavirus lineage B (β-CoV-B), including SARS-CoV-2, its variants, SARS-CoV bat SARSr-CoV WIV1. Interestingly, antibody family members competing with XG014 binding show reduced levels...
Abstract Hepatitis C virus (HCV), the main cause of non‐A, non‐B hepatitis in United States and possibly world, is believed to be transmitted primarily through parenteral exposure. Many screening supplemental tests are available detect antibodies HCV serum. The ability use commercial assays urine was investigated this study. A total 229 serum/urine matched samples were collected sequentially from forensic autopsy cases examined at Office Chief Medical Examiner, State Maryland. Testing...
ABSTRACT Hepatitis B virus (HBV) infection is a common cause of liver diseases worldwide. Existing drugs do not effectively eliminate HBV from infected hepatocytes; thus, novel curative therapies are needed. Enveloped-particle secretion key but poorly studied aspect the viral life cycle. Here, we report that GRP78 positively regulates enveloped-particle secretion. specific target preS1 binding; can upregulate in cell lines and sera chronic hepatitis patients. promoted intact HBV-particle an...