A5101442801- Traditional Chinese Medicine Analysis
- Natural product bioactivities and synthesis
- Chromatography in Natural Products
- Pharmacological Effects of Natural Compounds
- Medicinal Plant Pharmacodynamics Research
- Flavonoids in Medical Research
- Metabolomics and Mass Spectrometry Studies
- Plant-based Medicinal Research
- Analytical Chemistry and Chromatography
- Food Quality and Safety Studies
- Phytochemistry and Biological Activities
- Traditional Chinese Medicine Studies
- Phytochemicals and Antioxidant Activities
- Phytochemical Studies and Bioactivities
- Mass Spectrometry Techniques and Applications
- Analytical Methods in Pharmaceuticals
- Synthesis of Organic Compounds
- Tryptophan and brain disorders
- Ziziphus Jujuba Studies and Applications
- Bioactive Compounds and Antitumor Agents
- Metabolism and Genetic Disorders
- Medicinal Plants and Bioactive Compounds
- Amino Acid Enzymes and Metabolism
- Tea Polyphenols and Effects
- Ginseng Biological Effects and Applications
Shenyang Pharmaceutical University
2014-2023
Infinitus (China)
2011
Shenzhen Institute for Drug Control
2009-2010
Liaoning University of Traditional Chinese Medicine
2010
Shanghai Innovative Research Center of Traditional Chinese Medicine
2010
University of Michigan–Ann Arbor
2009
China Medical University
2009
Liaoning Provincial Food and Drug Administration
2009
ZheJiang Institute For Food and Drug Control
2009
Tasly Holding Group (China)
2009
A simple and reliable method of high-performance liquid chromatography (HPLC) was developed for the quality control oolong tea (the dry leaves Camellia sinensis ): included HPLC fingerprint quantitative determination seven bioactive compounds chemicals, namely, (-)-gallocatechin, (-)-epigallocatechin, (-)-epigallocatechin gallate, caffeine, (-)-epicatechin, gallocatechin (-)-epicatechin gallate. The analyses chemicals excelled in quantifying tea. chemical established using raw materials...
Seven new neolignanamides (1–7), including two pairs of cis- and trans-isomers, a lignanamide (8) were isolated from the EtOAc-soluble fraction an EtOH extract root bark Lycium chinense, together with 22 known phenolic compounds (9–30), four which obtained genus for first time. Compounds 5, 6, 7 are unusual dimers having rare connection mode between cinnamic acid amide units, while 7, 8 naturally occurring derived dissimilar amides. The amides, neolignanamides, lignanamides possess moderate...
Polyamines, one of the most important kind biomarkers in cancer research, were investigated order to characterize different types. An integrative approach which combined ultra-high performance liquid chromatography-tandem mass spectrometry detection and multiple statistical data processing strategies including outlier elimination, binary logistic regression analysis cluster had been developed discover characteristic lung liver cancer. The concentrations 14 polyamine metabolites biosamples...
Sambucus chinensis L. is a native perennial herb distributed throughout China. In traditional Chinese medicine (TCM), this known as Lu-Ying. Ursolic acid the major effective constituent of A rapid, sensitive, and accurate liquid chromatography-mass spectrometry (LC-MS) method for determination ursolic in rat plasma was developed validated. Plasma samples taken from rats that had received Lu-Ying extract orally were acidified with acetic then extracted mixture...
Schisandrin C (SCH-C) is a main and typical antioxidative lignan isolated from the fruits of Schisandra chinensis (Trucz.) Baill (a widely used traditional Chinese medicine). The present study aimed to characterize effect SCH-C on memory impairment further research pathological changes in Aβ1-42 -induced Alzheimer's disease mice. Mice were administration with daily for 5 days lateral cerebral ventricles using sterotaxically implanted cannula. Cognitive functions assessed by Y-maze test,...
Lipid quantification is the ultimate goal in lipidomics studies challenged by availability of standard compounds. A novel strategy for targeted based on LC-MS/MS parameters prediction and multivariate statistical analysis was developed quantitation lysophosphatidylcholines (LPCs) this study. Multiple linear regression models were established with acyl chain length number double bonds after correlation coefficients (R2pred) evaluated. Then related analytical including collision energy,...
Schisandra chinensis (Turcz.) Baill., as a Chinese functional food, has been widely used in neurological disorders including insomnia and Alzheimer's disease. The treatment of classical neuropsychiatric disorder depression is to be developed from chinensis. antidepressant-like effects the extracts (SCE), their probable involvement serotonergic, noradrenergic, dopaminergic, GABAergic glutamatergic systems were investigated by forced swim test (FST). Acute administration SCE (600 mg kg(-1),...
Salvia miltiorrhiza and Panax notoginseng were both considered to be beneficial cardiovascular diseases in traditional Chinese medicine often used combination. To examine the possible interaction between them, effects of active fractions these two herbs, salvianolic acids (SA) notoginsengnosides (NG), on platelet aggregation checked respectively or combination vitro vivo. Both rich plasma (PRP) washed after ADP induction checked. In study showed that SA NG had an inhibitory effect...
Developing drugs against metabolic-related disorders, including obesity and hyperlipidemia, is of importance for human health. Here, a bioactive phytochemical, protodioscin, isolated from the rhizomes Dioscorea nipponica (Rhizoma Dioscoreae Nipponicae), was identified its anti-hyperlipidemic effect. In hyperlipidemic rats, post-administration protodioscin significantly reduced time blood coagulation. addition, levels triglyceride, cholesterol, low-density high-density lipoproteins were also...
As a kind of medicine which can also be used as food, Alpinia oxyphylla Miq. has long clinical history in China. A variety studies demonstrated the significant neuroprotective activity effects chloroform (CF) extract from fruits oxyphylla. In order to further elucidate possible mechanisms CF mainly contains sesquiterpenes with neuroprotection on cognitive ability, mice were injected Aβ(1-42) and later this study. The results showed that long-term treatment enhanced performances behavior...
// Ran Liu 1 , Pei Li Cathy Wenchuan Bi 2 Ma 3 Yidi Yin Kaishun and Qing School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, China Division Life Science Center for Chinese Medicine, The Hong Kong University Technology, Kong, Basic Medical Sciences, Liaoning Traditional Correspondence to: Li, email: lqyxm@hotmail.com Keywords: polyamine, SCCL, cancer medication biomarkers, targeted metabolomics Received: April 28, 2017 Accepted: June 16, Published:...
In this study, we aim to assess possible impacts of essential oil (SEO) from Schisandra chinensis (Turcz.) Baill. (S. chinensis) on mice with cognition impairment. Our data showed that SEO improved the cognitive ability Aβ1-42 or lipopolysaccharides (LPS)-induced Alzheimer's disease (AD) and suppressed production tumor necrosis factor-a (TNF-a), interleukin-6 (IL-6), interleukin-1β (IL-1β) in hippocampus. Furthermore, inhibited p38 activation, but had little effect other signaling proteins...
In previous nephrotoxicity metabonomic studies, several potential biomarkers were found and evaluated. To investigate the relationship between therapeutic role of Radix Glycyrrhizae extract on Semen Strychni-induced renal failure, 12 typical are selected a simple LC-MS method has been developed validated. Citric acid, guanidinosuccinic taurine, guanidinoacetic uric creatinine, hippuric xanthurenic kynurenic 3-indoxyl sulfate, indole-3-acetic phenaceturic acid separated by Phenomenex Luna C18...
An HPLC method is described for determination of ferulic acid in rat plasma. The concentration plasma was determined after deproteinization with acetonitrile using sulfamethoxazole as internal standard. Chromatographic separations were performed on a C(18) stationary phase mobile composed acetonitrile-water (16:84, v/v) 1% glacial acetic acid. UV detection wavelength set at 320 nm. successfully applied to the pharmacokinetic parameters oral administration Rhizoma Chuanxiong and its compound...
Methodology for elucidating the therapeutic material basis and quality control indices of Traditional Chinese Medicinal Preparation Suanzaoren decoction was developed. Combination designed sixteen groups were obtained. Effects on frequency spontaneous motion, sleeping number duration in mice studied with combinations to get pharmacological data. RP-HPLC method developed analyze chromatographic profiles natural components all combinations. Areas (corrected by weighting amounts) peaks...