Polysaccharide extracted from okra (Abelmoschus esculentus (L.) Moench), a traditional functional food, is biologically active substance reported to possess hypoglycemic and anti-oxidative qualities. However, it unknown which polysaccharides play role have the potential mechanism. This present study assess possible impacts of novel polysaccharide isolated (OP) on mice fed with high-fat diet (HFD) combined an intraperitoneal injection (i.p.) 100 mg/kg streptozotocin (STZ) twice, induce type 2...

Probes embedded within a structure can enable prediction of material behavior or failure. Carefully assembled composites that respond intelligently to physical changes could be useful as intrinsic sensors. Molecular rotors are one such tool optically environmental changes. Here, we propose use molecular polymersome membrane report stress. Using supermolecular porphyrin-based fluorophores rotors, characterize in the optical emission these near-infrared (NIR) emissive probes hydrophobic core...

Recently, we identified 1-aminoanthracene as a fluorescent general anesthetic. To investigate the mechanism of action, photoactive analogue, 1-azidoanthracene, was synthesized. Administration 1-azidoanthracene to albino stage 40-47 tadpoles found immobilize animals upon near-UV irradiation forebrain region. The immobilization often reversible, but it characterized by longer duration consistent with covalent attachment ligand functionally important targets. IEF/SDS-PAGE examination irradiated...

Schisandrin C (SCH-C) is a main and typical antioxidative lignan isolated from the fruits of Schisandra chinensis (Trucz.) Baill (a widely used traditional Chinese medicine). The present study aimed to characterize effect SCH-C on memory impairment further research pathological changes in Aβ1-42 -induced Alzheimer's disease mice. Mice were administration with daily for 5 days lateral cerebral ventricles using sterotaxically implanted cannula. Cognitive functions assessed by Y-maze test,...

Schisandra chinensis (Turcz.) Baill., as a Chinese functional food, has been widely used in neurological disorders including insomnia and Alzheimer's disease. The treatment of classical neuropsychiatric disorder depression is to be developed from chinensis. antidepressant-like effects the extracts (SCE), their probable involvement serotonergic, noradrenergic, dopaminergic, GABAergic glutamatergic systems were investigated by forced swim test (FST). Acute administration SCE (600 mg kg(-1),...

Functional dyspepsia (FD) is a prevalent functional gastrointestinal disorder characterized by the absence of organic lesions; it affects nearly one-fifth global population. There currently no specific drug for treating it. Citri reticulatae Pericarpium (CRP) has been utilized in China millennia as therapeutic agent alleviating bloating and spleen–stomach disharmony. Nonetheless, curative efficacy precise molecular mechanisms implicated FD warrant further investigation. This study aims to...

Accumulating evidence suggests that particulate matter (PM2.5), as a major air pollutant, imposes certain degree of destruction and toxicity to the skin. It particularly impairs structure function epidermis. To study impact PM2.5 on skin, transcriptome analysis was performed PM2.5-exposed human primary keratinocytes. Functional annotation demonstrates significantly up-regulates cholesterol-metabolism-related genes. Via lipid extraction from treated three-dimensional epidermis tissue model...

Organic-inorganic nanocomposite fibers can avoid the agglomeration of single nanoparticles and reduce cost (nanoparticles assembled on surface nanofibers), but also produce new chemical, electrical, optical, other properties, with a composite synergistic effect. Aromatic polyimide (PI) is high-performance polymer rigid heterocyclic imide ring an aromatic benzene in its macromolecular framework. Due to excellent mechanical thermal stability, easy-to-adjust molecular structure, PI has been...

Protein assembly at the air-water interface (AWI) occurs naturally in many biological processes and provides a method for creating biomaterials. However, factors that control protein self-assembly AWI dynamic occur during adsorption are still underexplored. Using fluorescence microscopy, we investigated of model protein, human serum albumin minimally labeled with Texas Red fluorophore. Static information was obtained under low subphase concentrations. By varying solution concentration, ionic...

Important physiological, pathological, and technological processes occur at continuous dispersed phase interfaces. Understanding these is limited by inability to quantitate molecular events occurring the interface. To provide a model-independent measurement of protein concentration mobility interface, we employed confocal laser scanning microscopy (CLSM). Fluorescently labeled albumin fibrinogen were studied singly, pairwise, with surfactant, Pluronic F-127, in aqueous droplets. CLSM enables...

The interaction between synthetic polymers and proteins at interfaces is relevant to basic science as well a wide range of applications in biotechnology medicine. One particularly common important interface the air-water (AWI). Due special energetics dynamics molecules AWI, interplay polymer protein can be very different from that bulk solution. In this paper, we applied Langmuir-Blodgett technique fluorescence microscopy investigate how compression state polydimethylsiloxane (PDMS) film AWI...

Two new nor-triterpenoids ganodrenol A (1), B (2), and a natural product C (3), along with three known (4–6) were isolated from the fruiting bodies of Ganoderma lucidum. The chemical structures these isolates determined by 1 D 2 NMR, HRESIMS, X-ray crystallography analysis. inhibitory effects triterpenoids (1–6) against FAAH evaluated an in vitro assay, compound 4 showed inhibition rate 70.27%. In addition, cytotoxic effect compounds was LOVO, MCF-7, RAW264.7 cells, which displayed no...

<italic>Prunus persica</italic>has been frequently used as a functional and medicinal food in China other Asian countries.

1. Multidrug resistance (MDR) is a critical issue during chemotherapy of cancers. Epifriedelanol (Epi) the effective compounds from Root Bark Ulmus davidiana. This study aims to investigate effect Epi on MDR and its potential mechanism in adriamycin (Adr)-resistant K562/ADM cells.2. The MDR, P-glycoprotein (P-gp) multidrug resistance-associated proteins (MRPs) were investigated cells. In addition, alterations nuclear receptor pregnane X (PXR) constitutive androstane (CAR) mRNA expression...

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As a sustainable alternative technology to the cost- and energy-intensive Haber–Bosch method, electrochemical nitrogen (N2) reduction offers direct conversion of N2 NH3 under ambient conditions. Direct use noble metals or non-noble as electrocatalytic materials results in unsatisfactory properties because their low electrical conductivity stability. Herein, three-dimensional flexible carbon nanofiber (CNF/TiO2@CoS) nanostructures were prepared on surface CNF by using electrospinning,...

The design and preparation of advanced hybrid nanofibers with controllable microstructures will be interesting because their potential high-efficiency applications in the environmental energy domains. In this paper, a simple efficient strategy was developed for preparing zinc oxide–molybdenum disulfide (ZnO–MoS2) grown on polyimide (PI) by combining electrospinning, high-pressure hydrothermal process, situ growth. Unlike composite nanoparticles, structure is shown PI–ZnO to like skeleton...