A5091309783- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
- RNA Interference and Gene Delivery
- Photodynamic Therapy Research Studies
- Advanced NMR Techniques and Applications
- Endometriosis Research and Treatment
- Photoacoustic and Ultrasonic Imaging
- Reproductive System and Pregnancy
- Advanced biosensing and bioanalysis techniques
- Cancer, Hypoxia, and Metabolism
- Terahertz technology and applications
- Atomic and Subatomic Physics Research
- Supramolecular Chemistry and Complexes
- Immune Response and Inflammation
- Uterine Myomas and Treatments
- MicroRNA in disease regulation
- Sarcoma Diagnosis and Treatment
- Gas Sensing Nanomaterials and Sensors
- Ultrasound and Hyperthermia Applications
- Nuclear Structure and Function
- Cancer Cells and Metastasis
- Cancer Research and Treatments
- Muscle Physiology and Disorders
- Quantum Dots Synthesis And Properties
- Characterization and Applications of Magnetic Nanoparticles
Oregon State University
2016-2025
Oregon Health & Science University
2024
Portland State University
2023
Corvallis Environmental Center
2014-2018
University of Pennsylvania
2009-2014
Rutgers, The State University of New Jersey
2006-2013
The proposed project is aimed at enhancing the efficiency of epithelial ovarian cancer treatment and reducing adverse side effects chemotherapy using nanotechnology. Overexpression CD44 membrane receptor results in tumor initiation, growth, stem cells' specific behavior, development drug resistance, metastases. We hypothesize that a developed cancer-targeted delivery system combines siRNA with paclitaxel would successfully deliver its payload inside cells, effectively induce cell death,...
Owing to the outstanding near-infrared (NIR) optical properties, phthalocyanines (Pc) have promising potential as theranostic agents for fluorescence image-guided drug delivery and noninvasive treatment of deep tumors by photodynamic therapy (PDT). Nevertheless, clinical application is substantially limited poor water solubility, aggregation insufficient selectivity cancer cells. To address these issues, we developed a novel dendrimer-based platform tumor-targeted phthalocyanines. The...
A single agent-based theranostic nanoplatform was developed for concurrent NIR fluorescence imaging and combinatorial phototherapy with dual photodynamic (PDT) photothermal (PTT) therapeutic mechanisms.
Gestational choriocarcinoma (CC) is a rare and highly malignant cancer originating from the trophoblastic layers of placenta. Currently, methotrexate (MTX) first‐line treatment for CC; however, due to aggressive metastatic nature CC, multiple doses are often required, leading severe side effects lack tumor specificity. The first targeted MTX‐loaded polymersomes (Ps) designed efficient drug delivery CC tumors introduced. modification these Ps nanoplatforms with guanosine (Gn), which targets...
Cryptophane-A, comprised of two cyclotriguaiacylenes joined by three ethylene linkers, is a prototypal organic host molecule that binds reversibly to neutral small molecules via London forces. Of note are trifunctionalized, water-soluble cryptophane-A derivatives, which exhibit exceptional affinity for xenon in aqueous solution. In this paper, we report high-resolution X-ray structures and trifunctionalized derivatives crown–crown crown–saddle conformations, as well complexes with water,...
Fluorescence image-guided surgery combined with intraoperative therapeutic modalities has great potential for detection of oncologic targets and eradication unresectable cancer residues. Therefore, we have developed an activatable theranostic nanoplatform that can be used concurrently two purposes: (1) tumor delineation real-time near infrared (NIR) fluorescence signal during surgery, (2) targeted treatment to further eliminate unresected disease sites by non-toxic phototherapy. Methods: The...
Image-guided phototherapy is extensively considered as a promising therapy for cancer treatment. To enhance translational potential of this modality, we developed single agent-based biocompatible nanoplatform that provides both real time near-infrared (NIR) fluorescence imaging and combinatorial with dual photothermal photodynamic therapeutic mechanisms. The theranostic consists two building blocks: (1) silicon naphthalocyanine (SiNc) NIR phototherapeutic agent (2) copolymer, poly(ethylene...
Abstract Endometriosis is a painful disorder where endometrium‐like tissue forms lesions outside of the uterine cavity. Intraoperative identification and removal these are difficult. This study presents nanoplatform that concurrently delineates ablates endometriosis tissues using real‐time near‐infrared (NIR) fluorescence photothermal therapy (PTT). The consists dye, silicon naphthalocyanine (SiNc), capable both NIR imaging PTT, polymeric nanoparticle as SiNc carrier to following systemic...
Abstract Endometriosis is a devastating disease in which endometrial‐like tissue forms lesions outside the uterus. It causes infertility and severe pelvic pain ≈176 million women worldwide, there currently no cure for this disease. Magnetic hyperthermia could potentially eliminate widespread endometriotic but has not previously been considered treatment because conventional magnetic nanoparticles have relatively low heating efficiency can only provide ablation temperatures (>46 °C)...
mRNA therapeutics encapsulated in lipid nanoparticles (LNPs) offer promising avenues for treating various diseases. While vaccines anticipate immunogenicity, the associated reactogenicity of mRNA-loaded LNPs poses significant challenges, especially protein replacement therapies requiring multiple administrations, leading to adverse effects and suboptimal therapeutic outcomes. Historically, research has primarily focused on cargo, leaving role understudied this context. Adjuvanticity...
We have synthesized and characterized a library of near-infrared (NIR) heptamethine cyanine dyes for biomedical application as photoacoustic imaging photothermal agents. These hydrophobic were incorporated into polymer-based nanoparticle system to provide aqueous solubility protection the photophysical properties each dye scaffold. Among those analyzed, 13 compounds within nontoxic polymeric nanoparticles been selected exemplify structural relationships in terms photostability, imaging,...
Recently, we identified 1-aminoanthracene as a fluorescent general anesthetic. To investigate the mechanism of action, photoactive analogue, 1-azidoanthracene, was synthesized. Administration 1-azidoanthracene to albino stage 40-47 tadpoles found immobilize animals upon near-UV irradiation forebrain region. The immobilization often reversible, but it characterized by longer duration consistent with covalent attachment ligand functionally important targets. IEF/SDS-PAGE examination irradiated...
Phenylenethynylene (PE) rigid linkers (para and meta) were used to anchor pyrene the surface of TiO2 (anatase) ZrO2 nanoparticle thin films through two COOH groups an isophthalic acid (Ipa) unit. Four chromophore-linker models studied in solution bound. Two are novel meta-pyrene−PE linker systems: dimethyl 5-(3-(1-pyrenylethynyl)phenylethynyl)-isophthalate, carrying one pyrene, 5-(bis-3,5-(1-pyrenylethynyl)phenylethynyl)-isophthalate, two. These compared with para rigid-rods...
Efficient syntheses of trisubstituted cryptophane-A derivatives that are versatile host molecules for many applications reported. Trihydroxy cryptophane was synthesized in six or seven steps with yields as high 9.5%. By a different route, trihydroxy modified three propargyl, allyl, benzyl protecting groups 4.1−5.8% just steps. Hyperpolarized 129Xe NMR chemical shifts 57−65 ppm were measured these cryptophanes.
Muscle atrophy occurs during chronic diseases, resulting in diminished quality of life and compromised treatment outcomes.There is a high demand for therapeutics that increase muscle mass while abrogating the need special dietary exercise requirements.Therefore, we developed an efficient nanomedicine approach capable increasing mass.Methods: The therapy based on nanoparticle-mediated delivery follistatin messenger RNA (mRNA) to liver after subcutaneous administration.The delivered mRNA...
Due to the limited heating efficiency of available magnetic nanoparticles, it is difficult achieve therapeutic temperatures above 44 °C in relatively inaccessible tumors during hyperthermia following systemic administration nanoparticles at clinical dosage (≤10 mg kg-1 ). To address this, a method for preparation with ultrahigh capacity presence an alternating field (AMF) presented. The low nitrogen flow rate 10 mL min-1 thermal decomposition reaction results cobalt-doped magnetite (Fe3 O4 )...
A novel nanotechnology-based drug delivery system (DDS) targeted at pancreatic cancer cells was developed, characterized, and tested. The consisted of liposomes as carriers, an anticancer (paclitaxel) a chemotherapeutic agent, modified synthetic somatostatin analog, 5-pentacarbonyl-octreotide, ligand for receptor 2 (SSTR2), targeting moiety cancer. cellular internalization, cytotoxicity, antitumor activity the DDS were tested in vitro using human ductal adenocarcinoma (PDAC) with different...
<para xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> We report a ZnO-nanostructure-based quartz crystal microbalance (nano-QCM) device for biosensing applications. ZnO nanotips are directly grown on the sensing area of conventional QCM by metalorganic chemical vapor deposition (MOCVD). Scanning electron microscopy (SEM) shows that dense and uniformly aligned along normal to substrate surface. By using superhydrophilic nano-ZnO surface, more than...