A5084229113- RNA Interference and Gene Delivery
- Nanoparticle-Based Drug Delivery
- Advanced biosensing and bioanalysis techniques
- Nanoplatforms for cancer theranostics
- Dendrimers and Hyperbranched Polymers
- Inhalation and Respiratory Drug Delivery
- Cancer, Hypoxia, and Metabolism
- Insect Resistance and Genetics
- Advanced Drug Delivery Systems
- Cancer Research and Treatments
- Cell death mechanisms and regulation
- Cancer-related Molecular Pathways
- Drug Transport and Resistance Mechanisms
- DNA and Nucleic Acid Chemistry
- Drug Solubulity and Delivery Systems
- Metal complexes synthesis and properties
- Glycosylation and Glycoproteins Research
- Lipid Membrane Structure and Behavior
- Mitochondrial Function and Pathology
- Lung Cancer Research Studies
- Immunotherapy and Immune Responses
- Advanced Polymer Synthesis and Characterization
- Graphene and Nanomaterials Applications
- Cancer therapeutics and mechanisms
- Monoclonal and Polyclonal Antibodies Research
Rutgers, The State University of New Jersey
2015-2024
Rutgers Cancer Institute of New Jersey
2012-2024
Environmental and Occupational Health Sciences Institute
2005-2024
Oregon State University
2013-2014
Rutgers Sexual and Reproductive Health and Rights
2011-2013
Cancer Institute of Florida
2003-2013
Hebrew University of Jerusalem
2011
State of New Jersey
2009-2010
University of Pennsylvania
2006-2009
Pharmac
2008
Co-delivery of Doxorubicin and siRNAs by mesoporous silica nanoparticles into multidrug-resistance cancer cells with minimal premature release significantly enhances the efficacy chemotherapy conquering nonpump resistance possibly bypassing efflux pump (see image). Detailed facts importance to specialist readers are published as "Supporting Information". Such documents peer-reviewed, but not copy-edited or typeset. They made available submitted authors. Please note: The publisher is...
Aims: To develop a novel nanomedicine approach for the treatment of multidrug-resistant (MDR) cancer by combining an anticancer drug and suppressors cellular resistance within one multifunctional nanocarrier-based delivery system (NDS). Materials & methods: The NDS consisted cationic liposomes (carrier, 100–140 nm), doxorubicin (DOX, drug), siRNA targeted to MRP1 BCL2 mRNA (suppressors pump nonpump cellular-resistance, respectively). resulting approximately 500 nm complex has zeta potential...
Carrier-mediated delivery of drugs into the cytosol is often limited by either release from carrier or an internalizing endolysosome. Here, loading, delivery, and cytosolic uptake drug mixtures degradable polymersomes are shown to exploit both thick membrane these block copolymer vesicles their aqueous lumen as well pH-triggered within endolysosomes. Our initial in vivo studies demonstrate growth arrest shrinkage rapidly growing tumors after a single intravenous injection composed...
Shape effects of synthetic carriers are largely unexplored in vivo, although recent findings suggest that flexible filaments can persist the circulation even if microns length. Here, to better assess biodistribution, a near-infrared fluorophore (NIRF) was incorporated into such block copolymer "filomicelles", and both vivo ex imaging show majority these wormlike micelles remain for at least day after intravenous injection. NIRF further suggests filomicelles convect tumor some fragments...
A tumor targeted mesoporous silica nanoparticles (MSN)-based drug delivery system (DDS) was developed for inhalation treatment of lung cancer. The capable effectively delivering inside cancer cells anticancer drugs (doxorubicin and cisplatin) combined with two types siRNA to MRP1 BCL2 mRNA suppression pump nonpump cellular resistance in non-small cell carcinoma, respectively. Targeting MSN achieved by the conjugation LHRH peptide on surface via poly(ethylene glycol) spacer. delivered...
The central problem in cancer chemotherapy is the severe toxic side effects of anticancer drugs on healthy tissues. Invariably impose dose reduction, treatment delay, or discontinuance therapy. To limit adverse organs, we proposed a drug delivery system (DDS) with specific targeting ligands for cells. DDS minimizes uptake by normal cells and enhances influx retention This includes three main components: ( i ) an apoptosis-inducing agent (anticancer drug), ii moiety-penetration enhancer, iii...
The relative difference in polymeric architectures of dendrimer and linear bis(poly(ethylene glycol)) (PEG) polymer conjugation with paclitaxel has been described. Paclitaxel, a poorly soluble anticancer drug, was covalently conjugated PAMAM G4 hydroxyl-terminated bis(PEG) for the potential enhancement drug solubility cytotoxicity. Both conjugates were characterized by 1NMR, HPLC, MALDI/TOF. In addition, molecular conformations dendrimer, bis(PEG), paclitaxel, its studied modeling....
A novel internally quaternized and surface-acetylated poly(amidoamine) generation four dendrimer (QPAMAM-NHAc) was synthesized evaluated for intracellular delivery of siRNA. The proposed as a nanocarrier possesses the following advantages: (1) modified neutral surface low cytotoxicity enhanced cellular internalization; (2) existence cationic charges inside (not on outer surface) resulting in highly organized compact nanoparticles, which can potentially protect nucleic acids from degradation....
A novel cancer targeted, internally cationic and surface neutral polyamidoamine (PAMAM) dendrimer, was designed, synthesized, evaluated as a nanocarrier for the targeted intracellular delivery of siRNA. The dendrimer contained synthetic analog Luteinizing hormone-releasing hormone targeting moiety. proposed system possesses following advantages: (1) internal charges complexation with siRNA enhanced protection; (2) low cytotoxicity; (3) lesser degree quaternization offering free tertiary...