A5102940547- Natural Compounds in Disease Treatment
- Retinal Diseases and Treatments
- Ocular Surface and Contact Lens
- Cell death mechanisms and regulation
- Cancer Mechanisms and Therapy
- Glaucoma and retinal disorders
- Traditional Chinese Medicine Analysis
- Ocular Infections and Treatments
- Neurological Complications and Syndromes
- Ocular Diseases and Behçet’s Syndrome
- Hip and Femur Fractures
- Corneal surgery and disorders
- Autophagy in Disease and Therapy
- Retinal Development and Disorders
- Hypothalamic control of reproductive hormones
- Ophthalmology and Visual Impairment Studies
- Salivary Gland Tumors Diagnosis and Treatment
- Neuroblastoma Research and Treatments
- Pancreatic and Hepatic Oncology Research
- Herpesvirus Infections and Treatments
- Ginseng Biological Effects and Applications
- Hip disorders and treatments
- Protein purification and stability
- Cerebrovascular and genetic disorders
- Global Maternal and Child Health
Guangzhou University of Chinese Medicine
2012-2021
Bristol-Myers Squibb (United States)
2013
Guangdong Provincial Hospital of Traditional Chinese Medicine
2009-2011
Rutgers, The State University of New Jersey
2005
The central problem in cancer chemotherapy is the severe toxic side effects of anticancer drugs on healthy tissues. Invariably impose dose reduction, treatment delay, or discontinuance therapy. To limit adverse organs, we proposed a drug delivery system (DDS) with specific targeting ligands for cells. DDS minimizes uptake by normal cells and enhances influx retention This includes three main components: ( i ) an apoptosis-inducing agent (anticancer drug), ii moiety-penetration enhancer, iii...
Pancreatic cancer is the seventh leading cause of cancer-related death worldwide, and despite advancements in disease management, 5 -year survival rate stands at only 12%. Triptolides have potent anti-tumor activity against different types cancers, including pancreatic cancer, however poor solubility toxicity limit their translation into clinical use. We synthesized a novel pro-drug triptolide, ( E )–19-[(1’-benzoyloxy-1’-phenyl)-methylidene]-Triptolide (CK21), which was formulated an...
Objective: To investigate the effect of Mingmu Xiaomeng tablets (MMXM) on expression phosphoinositide 3-kinase (PI3K)/Akt/mammalian target rapamycin (mTOR)-related proteins in a diabetic rat model. Methods: Thirty-two male Sprague Dawley rats were randomly divided into four groups: normal control (NC), model (DM) control, MMXM, and calcium dobesilate (CD) Rats injected with streptozotocin (STZ) used as an experimental diabetes After 14 weeks, autophagy PI3K/Akt/mTOR signaling pathway...
Abstract Recently the Salvia Miltiorrhiza–Moutan Cortex (SM‐MC) herb pair is considered as a promising Chinese medicinal mixture exhibiting range of pharmacological activities, including treating cardiovascular disease due to its unique composition. In this study, we conducted comparative pharmacokinetic analysis seven main bioactive components SM‐MC in different model rat. A straightforward ultra‐performance liquid chromatography–tandem mass spectrometry (UPLC‐MS/MS) strategy that could...
Background: Trachoma-induced upper eyelid cicatricial entropion (UCE) is a common and challenging disease.Surgeons have developed various surgical techniques to address UCE in the world.However, there are few reports about surgery for Chinese patients.Our study aims evaluate esthetic functional outcomes of correction trachoma-induced using levator weakening combined with tarsotomy an anterior lamella recession procedure China.Methods: A retrospective non-comparative was performed...
Objective To evaluate the effect of operation therapy polypus lower lacrimal punctum.Methods Of 21 patients(39 eyes)ofpolypus accepted punctum reconstruction.Results Followed-up 3 months to 2 years,37 eyes were cured and improved without any relapse.Conclusions Treatment by means reconstruction is a favorable method.The simple affirmative. Key words: Polypus punctum; Operation therapy; Lower
Abstract Background Pancreatic cancer is the seventh leading cause of cancer-related death worldwide, and despite advancements in disease management, 5-year survival rates stands at only 9%. Triptolides have potent anti-tumor activity against different types cancers, including pancreatic cancer, however poor solubility toxicity limit their translation into clinical use. Methods We synthesized a novel pro-drug triptolide, ( E )-19-[(1’-benzoyloxy-1’-phenyl)-methylidene]-Triptolide (CK21),...
Objective To explore the sequencial changes of tear IL-6 mRNA and IL-10 in patients penetrating keratoplasty (PKP) surgery, to understand inflammatory response before after PKP surgery wound healing mechanism. Methods Selected from July 2007 December with 20 healthy subjects as a control group. Tear was collected 1d 1w, 3w fluorescence quantitative PCR used detect tear. Results The CT value at pre-operation, 1w post-operation 18.471±2.698, 18.723±2.640 20.706±2.445, respectively, that...
The current paper reviews the recent studies on relationship between vascular endothelial growth factor (VEGF) and ocular neovascularization diseases to explain it molecular biology level,and evaluate effects of Bevacizumab (Avatin) for treating diseases. Key words: neovascularization; Bevacizumab (Avatin); side effect
Open calcaneal fractures are often accompanied by high energy trauma, because of the complex anatomy posterior foot, with characteristics incidence infection and other complications. Surrounding soft tissues damage increases in open fractures, improper handling can lead to wound infection, osteomyelitis, even amputation, potentially damaging. How seek balance between repair tissue fracture reduction internal fixation recovery foot bone structure save hindfoot function based , maximize...
To compare clinical efficacy of repositioning with precise-surgical-opening intramedullary nail insertion and traditional in treating unstable femoral intertrochanteric fractures closed-reposition difficulty.Clinical data 58 patients after difficulty (AO 31A2.2-3.3) were retrospective analyzed. Among them, 32 treated first open then reduction operation(modified reductuon group) including 9 males 23 females an average age (80.9±11.1) years old ranging from 46 to 99 old; 26 by...
Abstract The MYC family of proto-oncogenes is activated in a variety cancers, including multiple high-risk pediatric malignancies. c-MYC (MYC) ubiquitously expressed human tissues, while MYCN (MYCN) has tissue and developmentally restricted expression patterns. In both neuroblastoma medulloblastoma, enhanced activity either or drives disease. As transcription factors, proteins exert oncogenic functions through protein-protein interaction networks that alter gene expression, but also mediate...