A5100612180- Analytical Chemistry and Chromatography
- Traditional Chinese Medicine Analysis
- Helicobacter pylori-related gastroenterology studies
- Phytochemistry and biological activity of medicinal plants
- Drug-Induced Hepatotoxicity and Protection
- Gastroesophageal reflux and treatments
- Ginseng Biological Effects and Applications
- Natural product bioactivities and synthesis
- Phagocytosis and Immune Regulation
- Extracellular vesicles in disease
- Analytical Methods in Pharmaceuticals
- Hops Chemistry and Applications
- Ocular Infections and Treatments
- Chromatography in Natural Products
- Botanical Research and Applications
- Silymarin and Mushroom Poisoning
- Catalytic C–H Functionalization Methods
- Lung Cancer Treatments and Mutations
- Heavy Metals in Plants
- Wound Healing and Treatments
- RNA Interference and Gene Delivery
- Adenosine and Purinergic Signaling
- Berberine and alkaloids research
- Phytochemistry and Biological Activities
- Biocrusts and Microbial Ecology
Northeast Agricultural University
2024-2025
Nanjing Agricultural University
2025
Northwest Institute of Eco-Environment and Resources
2022-2024
Chinese Academy of Sciences
2022-2024
University of South China
2024
Zhejiang University
2024
Hebei General Hospital
2018-2024
Heilongjiang Provincial Academy of Agricultural Sciences
2024
Southwest University
2023
The University of Tokyo
2018
A catalytic amount of an iron salt and bipyridine ligand in the presence organozinc base activates ortho C–H bond a carboxamide, following reaction with alkene such as ethylene gas (1 atm), styrene derivatives, vinylsilane or vinylboron derivatives via carbometalation gives putative alkylzinc intermediate. This intermediate can be further reacted electrophiles deuterium oxide allyl bromide. When monosubstituted alkenes are used substrate, linear alkyl product is selectively obtained. The...
Aloe vera is an important raw material for medicine and food, aloe‐emodin (AE) one of the main extracts . The aim this study was to investigate inhibitory effect AE on multidrug‐resistant Escherichia coli (MDR -E. ) anti‐inflammatory mechanism pathogenic bacterial infection. minimum concentration against MDR determined in vitro. potential therapeutic targets signaling pathways inflammation were predicted by network pharmacology, a mouse infection model constructed intraperitoneal injection...
A novel quantitative method using high-performance liquid chromatography coupled to electrospray ionization tandem mass spectrometry was developed for simultaneous determination of the important active constituents including shionone, luteolin, quercetin, kaempferol and ferulic acid in Aster tataricus from different habitats. The separation performed on a C18 column with acidified aqueous acetonitrile gradients. Quantification analytes achieved by use hybrid quadrupole spectrometer. Multiple...
Xuanmai Ganjie Granules (XMGJ), a widely used Chinese herbal formula in the clinic, is for treatment of sore throats and coughs. Despite chemical constituents having been clarifying by our previous studies, both metabolism pharmacokinetic studies XMGJ are unclear. This study aimed to explore disposition process vivo. A sensitive selective ultra-high performance liquid chromatography with quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF-MS) method was developed analyze absorbed...
Osimertinib, a new-generation inhibitor of the epidermal growth factor, has been used for clinical treatment advanced T790M mutation-positive tumors. In this research, an original analysis method was established quantification osimertinib by ultra-performance liquid chromatography with time flight mass spectrometry (UPLC-TOF-MS) in rat plasma. After protein precipitation acetonitrile and sorafinib (internal standard, IS), they were chromatographed through Waters XTerra MS C18 column. The...
The 5-year overall survival rate of acute myeloid leukemia (AML) is less than 30%. Improving clinical outcomes still a challenge for AML treatment. Simultaneous use chemotherapeutic drugs and targeting apoptosis pathways has become first-line treatment AML. Myeloid cell 1 (MCL-1) candidate target In this study, we demonstrated that inhibition the anti-apoptotic protein MCL-1 by AZD5991 synergistically increased agent cytarabine (Ara-C)-induced in lines primary patient samples. Apoptosis...
Abstract Background In Chinese healthcare settings, drug selection decisions are predominantly influenced by the Pharmacy & Therapeutics Committee (PTC). This study evaluates two recently introduced potassium-competitive acid blockers, vonoprazan (VPZ) and tegoprazan (TPZ), utilizing Evidence Value: Impact on DEcisionMaking (EVIDEM) framework. Methods The employed 10th edition of EVIDEM, which includes a core model with five domains 13 criteria. Two independent expert panels were...
Porcine reproductive and respiratory syndrome virus (PRRSV) is a major swine pathogen, which can survive host antiviral immunity with various mechanisms. PRRSV infection induces macroautophagy/autophagy, facilitating replication. MALT1, central immune regulator, was manipulated by to optimize viral at different stages of the cycle. In this study, key role MALT1 in autophagy regulation during characterized, enlightening flux favor spread persistent infection. PRRSV-induced confirmed...
Trauma is a common cause of cutaneous surgical disease with an increased risk secondary infection in cat clinics. Platelet-rich fibrin (PRF), platelet and leukocyte concentrate containing multiple cytokines growth factors, known to accelerate the healing wounds. However, how PRF affects wound trauma model has not been fully investigated. The study aimed examine impact on skin model. In this study, from cats was successfully produced for our investigation. models feline were effectively...
Abstract Recently the Salvia Miltiorrhiza–Moutan Cortex (SM‐MC) herb pair is considered as a promising Chinese medicinal mixture exhibiting range of pharmacological activities, including treating cardiovascular disease due to its unique composition. In this study, we conducted comparative pharmacokinetic analysis seven main bioactive components SM‐MC in different model rat. A straightforward ultra‐performance liquid chromatography–tandem mass spectrometry (UPLC‐MS/MS) strategy that could...
<title>Abstract</title> Background In Chinese healthcare settings, decisions regarding drug selection are predominantly guided by the Pharmacy & Therapeutics Committee (PTC). This study focuses on two recently introduced potassium-competitive acid blockers in China, vonoprazan (VPZ) and tegoprazan (TPZ). The objective was to assess these drugs using Evidence Value: Impact DEcisionMaking (EVIDEM) framework. Methods utilized 10th edition of EVIDEM, comprising a core model with five domains...
Sepsis-associated acute kidney injury (AKI) is a serious complication of systemic infection with high morbidity and mortality in patients. However, no effective drugs are available for AKI treatment. Dexmedetomidine (DEX) an alpha 2 adrenal receptor agonist antioxidant anti-apoptotic effects. This study aimed to investigate the therapeutic effects DEX on sepsis-associated elucidate role mitochondrial dynamics during this process.
Gravel mulching is a widely employed strategy for water conservation in arid agricultural regions, with potential implications soil carbon (C) sequestration and greenhouse gas emissions. However, respiration CO2-C emissions remain uncertain owing to less consideration of the influence precipitation patterns planting age. In this study, we investigated rate (Rsoil) cumulative emission (Ccum), both measured over period 72 h, along properties enzyme activities under different conditions based...