A5046983379- Metabolomics and Mass Spectrometry Studies
- Birth, Development, and Health
- Neuroscience of respiration and sleep
- Thermal Expansion and Ionic Conductivity
- Drug-Induced Adverse Reactions
- Fungal Infections and Studies
- Microbial Community Ecology and Physiology
- Ocular Infections and Treatments
- Antibiotics Pharmacokinetics and Efficacy
- Vitamin D Research Studies
- Eicosanoids and Hypertension Pharmacology
- Circular RNAs in diseases
- Inflammatory mediators and NSAID effects
- Drug Transport and Resistance Mechanisms
- Nitric Oxide and Endothelin Effects
- Monoclonal and Polyclonal Antibodies Research
- Cancer, Hypoxia, and Metabolism
- Computational Drug Discovery Methods
- Restraint-Related Deaths
- T-cell and B-cell Immunology
- Bacteriophages and microbial interactions
- Antifungal resistance and susceptibility
- Genomics and Phylogenetic Studies
- Per- and polyfluoroalkyl substances research
- Chemotherapy-induced cardiotoxicity and mitigation
Hebei General Hospital
2021-2023
China Pharmaceutical University
2014-2020
Nanjing University
2019
Nanjing General Hospital of Nanjing Military Command
2014-2019
Jinling Institute of Technology
2014
Perfluorooctane sulfonate (PFOS), a new type of persistent organic pollutant in the environment water, has drawn significant attention recent years due to its widespread prevalence and high toxicity. Neurotoxicity is regarded as one major toxic effects PFOS, while research studies on PFOS-induced depression underlying mechanisms remain scarce. In this study, behavioral tests revealed depressive-like behaviors PFOS-exposed male mice. Neuron damages including pyknosis staining deepening were...
Abstract Doxorubicin (DOX)‐induced cardiotoxicity impedes its clinical application, but the mechanisms have not been thoroughly elucidated. Based on circRNA and mRNA expression profiles, we illustrated RNA signature changes during DOX‐induced cardiotoxicity; mechanism exploration biomarkers screening were also conducted. Twelve mice randomly divided into two groups, induction group was treated with doxorubicin, control given an equal quantity of saline. After confirmation myocardial injury...
Individual variation in pharmacokinetics of faropenem is significant. We attempted to predict drug response using a pharmacometabonomic approach. Metabolic profiling was performed on predose plasma samples from 36 healthy volunteers by gas chromatography–mass spectrometry (GC/MS), with 204 endogenous metabolites detected. Plasma concentration measured after administration, high pressure liquid chromatography-tandem mass spectroscopy (LC/MS/MS), and the pharmacokinetic parameters were...
Doxorubicin (DOX) is an effective antineoplastic agent. However, the clinical application of DOX limited by DOX-induced cardiotoxicity. This study aimed to investigate role Mincle in cardiac injury and its potential mechanisms. The expression was detected cardiotoxicity induced mice, depleted macrophages were used confirm main source expression. Then, knockout or activation models constructed explore effects on injury, alterations Mincle/Syk/NF-κB signaling pathway macrophage polarization...