A5047377288- Sirtuins and Resveratrol in Medicine
- Ginseng Biological Effects and Applications
- Bacterial Genetics and Biotechnology
- Antibiotic Resistance in Bacteria
- Escherichia coli research studies
- Identification and Quantification in Food
- SARS-CoV-2 and COVID-19 Research
- Autophagy in Disease and Therapy
- Advanced Cellulose Research Studies
- Genomics and Phylogenetic Studies
- CRISPR and Genetic Engineering
- Pharmacological Effects of Natural Compounds
- COVID-19 Clinical Research Studies
- Natural product bioactivities and synthesis
- Chromosomal and Genetic Variations
- Natural Fiber Reinforced Composites
- Genomics, phytochemicals, and oxidative stress
- Lignin and Wood Chemistry
- Inflammasome and immune disorders
- Medicinal Plants and Neuroprotection
- Histone Deacetylase Inhibitors Research
- Vitamin D Research Studies
- Bamboo properties and applications
- Skin Protection and Aging
- Medicinal Plants and Bioactive Compounds
Fudan University
2024
Changchun University of Chinese Medicine
2018-2024
Southwest Forestry University
2023-2024
Linyi University
2024
Ningbo University
2024
Henan University of Traditional Chinese Medicine
2022-2023
First Affiliated Hospital of Henan University of Traditional Chinese Medicine
2022-2023
Southern Medical University
2021-2022
University of Copenhagen
2022
University of North Carolina at Chapel Hill
2019-2021
The recent outbreak of human infections caused by SARS-CoV-2, the third zoonotic coronavirus has raised great public health concern globally. Rapid and accurate diagnosis this novel pathogen posts challenges not only clinically but also technologically. Metagenomic next-generation sequencing (mNGS) reverse-transcription PCR (RT-PCR) have been most commonly used molecular methodologies. However, each their own limitations. In study, we developed an isothermal, CRISPR-based diagnostic for...
Targeting SIRT1 signaling pathway could improve glucose aerobic metabolism and mitochondrial biosynthesis to resist cardiac neurological injuries. Ginsenoside Rc has been identified for targeting function, but how ginsenoside interacts with regulate energy in cardiomyocytes neurons under physiological or ischemia/reperfusion (I/R)-injured conditions not clearly investigated. Here, we confirm the interaction of on residue sites promoting its activity. significantly promotes biogenesis...
Enteric Escherichia coli survives the highly acidic environment of stomach through multiple acid resistance (AR) mechanisms. The most effective system, AR2, decarboxylates externally-derived glutamate to remove cytoplasmic protons and excrete GABA. first described AR1, does not require an external amino acid. Its mechanism has been determined. regulation AR systems their coordination with broader cellular metabolism fully explored.We utilized a combination ChIP-Seq gene expression analysis...
Oral decoction is widely applied in traditional Chinese medicines. The polysaccharides of promote the exposure small molecules and increase their bioavailability. This study mainly compared component activities total ginsenosides (TGS) ginseng extract (GE) on immunosuppressed mice induced by cyclophosphamide. Thirty-two were randomly divided into control, model, TGS, GE groups. orally administered for 28 days then injected with cyclophosphamide last four days. results analysis showed content...
Psoriasis is an immune-related skin disease notable for its chronic inflammation of the entire system. Alzheimer's (AD) more prevalent in psoriasis than general population. Immune-mediated pathophysiologic processes may link these two diseases, but mechanism still unclear. This article aimed to explore potential molecular mechanisms and AD.Gene expression profiling data AD were acquired Gene Expression Omnibus (GEO) database. Set Enrichment Analysis (GSEA) single-sample GSEA (ssGSEA) first...
Aerobic cellular respiration provides chemical energy, adenosine triphosphate (ATP), to maintain multiple functions. Sirtuin 1 (SIRT1) can deacetylate peroxisome proliferator-activated receptor gamma coactivator alpha (PGC-1α) promote mitochondrial biosynthesis. Targeting energy metabolism is a potential strategy for the prevention and treatment of various diseases, such as cardiac neurological disorders. Ginsenosides, one major bioactive constituents Panax ginseng, have been extensively...
Abstract Background The collagen hydrolysates as a cosmetic material have already been wide application. At present, few studies concern with transdermal behavior of in vitro. Objective Deer sinew contains rich content 82.12%. Thus, this article mainly the effect deer (DSCH) on mouse skin, ex vitro, and to explore skincare protection percutaneous proteins. Methods Collagen were extracted by 0.2% HCl two‐step enzymatic method pepsin‐trypsin. 17 amino acids DSCH was detected precolumn...
Aging is a complex, degenerative process associated with various metabolic abnormalities. Ginsenosides (GS) the main active components of Panax ginseng, which has anti-aging effects and improves metabolism. However, effect mechanism GS in middle-aged mice not been elucidated. In this study, after 3-month treatment significantly improved grip strength, fatigue resistance, cognitive indices, cardiac function 15-month-old mice. Meanwhile, reduced fat content obviously inhibited histone H2AX...
During an immune response, macrophages undergo systematic metabolic rewiring tailored to support their functions. Branched-chain amino acid (BCAA) metabolism has been reported modulate macrophage function; however, its role in alternative activation remain unclear. We aimed investigate the of BCAA activation.
As one of most important traditional Chinese medicine resources, the oviduct female Rana chensinensis (Chinese brown frog) was widely used in treatment asthenia after sickness or delivery, deficiency vigor, palpitation, and insomnia. Unlike other vertebrates, significantly expands during prehibernation, contrast to breeding period. To explain this phenomenon at molecular level, protein expression profiles period prehibernation were observed using isobaric tags for relative absolute...
Deer antler, as the only mammalian regenerative appendage, provides an optimal model to study medicine. Antler harvested from red deer or sika were mainly objects used disclose mechanism underlying antler regeneration over past decades. A previous proteomic technology reveal signaling pathways of stem cell derived deer. Moreover, transcriptome tip provide us with essential genes, which regulated development and regeneration. However, comparison between has not been well studied. In our...
Vertical transmission of group B Streptococcus (GBS) is among the leading causes neonatal illness and death. Colonization with GBS usually screened weeks before delivery during pregnancy, on basis which preventive measures, such as antibiotic prophylaxis, were taken. However, accuracy an antenatal screening strategy has been questionable because intermittent nature carriage. We developed a simple-to-use, rapid, CRISPR-based assay for detection. conducted studies in prospective cohort 412...
Resveratrol (RSV) is a polyphenol antioxidant that has been shown to have neuroprotective effects. We sought molecular mechanisms emphasize the anti-inflammatory activity of RSV in traumatic brain injury (TBI) mice associated with endoplasmic reticulum stress (ERS). After establishing three experimental groups (sham, TBI, and TBI+RSV), we explored results after TBI on ERS caspase-12 apoptotic pathways. The expression levels C/EBP homologous protein (CHOP), glucose regulated 78kD (GRP78),...
The antler regeneration has been well studied for the past two decades and adopted in regenerative medicine model studying on developmental biology. Despite our growing knowledge of functional molecules regulating regeneration, we still do not know whether from different deer species possess exact same mechanism or not. Our previous comparative study between sika red suggests that metabolic pathways them are profoundly based protein level. Therefore, metabolomic technology is used to...
The use of animal medicine has a long history in China, it the characteristics high curative effect,strong activity, wide application and great potential. However,the circulation current market mixed counterfeit variety complex. Molecular identification technology DNA barcoding is an emerging molecular biotechnology recent years, powerful supplement to traditional methods. This method can well identify species at level accuracy, medicines quickly monitor effectively. article summarizes...