A5081114493- Bacterial Genetics and Biotechnology
- Neural dynamics and brain function
- Antibiotic Resistance in Bacteria
- Speech and Audio Processing
- Hearing Loss and Rehabilitation
- Escherichia coli research studies
- Multisensory perception and integration
- Functional Brain Connectivity Studies
- African history and culture studies
- Nanowire Synthesis and Applications
- Advanced Memory and Neural Computing
- Advanced biosensing and bioanalysis techniques
- Neural and Behavioral Psychology Studies
- Global Healthcare and Medical Tourism
- Medicine and Dermatology Studies History
- Visual perception and processing mechanisms
- Advanced Adaptive Filtering Techniques
- Olfactory and Sensory Function Studies
- Quantum Dots Synthesis And Properties
- Clostridium difficile and Clostridium perfringens research
- Gut microbiota and health
Boston University
2013-2022
Center for Systems Biology
2020
Enteric Escherichia coli survives the highly acidic environment of stomach through multiple acid resistance (AR) mechanisms. The most effective system, AR2, decarboxylates externally-derived glutamate to remove cytoplasmic protons and excrete GABA. first described AR1, does not require an external amino acid. Its mechanism has been determined. regulation AR systems their coordination with broader cellular metabolism fully explored.We utilized a combination ChIP-Seq gene expression analysis...
At a cocktail party, we can broadly monitor the entire acoustic scene to detect important cues (e.g., our names being called, or fire alarm going off), selectively listen target sound source conversation partner). It has recently been observed that individual neurons in avian field L (analog mammalian auditory cortex) display broad spatial tuning single targets and selective embedded spatially distributed mixtures. Here, describe model inspired by these experimental observations apply it...
Attentional modulation of cortical networks is critical for the cognitive flexibility required to process complex scenes. Current theoretical frameworks attention are based almost exclusively on studies in visual cortex, where attentional effects typically modest and excitatory. In contrast, auditory cortex can be large suppressive. A framework explaining lacking, preventing a broader understanding mechanisms underlying attention. Here, we present network model primary (A1). key mechanism...
Cross-modal interactions of auditory and visual temporal modulation were examined in a game-like experimental framework. Participants observed an audiovisual stimulus (an animated, sound-emitting fish) whose sound intensity and/or size oscillated sinusoidally at either 6 or 7 Hz. made speeded judgments about the rate modality while doing their best to ignore information from other modality. Modulation task-irrelevant matched task-relevant (congruent conditions), was (incongruent had no...
Listening in an acoustically cluttered scene remains a difficult task for both machines and hearing-impaired listeners. Normal-hearing listeners accomplish this with relative ease by segregating the into its constituent sound sources, then selecting attending to target source. An assistive listening device that mimics biological mechanisms underlying behavior may provide effective solution those difficulty environments (e.g., cocktail party). Here, we present binaural segregation algorithm...
We used a specially designed computer game to examine behavioral consequences of audiovisual integration. Target stimuli (animated fish swimming across the screen) were modulated in size and/or emitted an amplitude-modulated sound. Modulations, visual or auditory, at 6 7 Hz (corresponding “slow” and “fast”). In one game, subjects instructed categorize successive as “fast” based on auditory modulations; another they categorized modulation rate. each ignore input from task-irrelevant modality....
Abstract Listening in an acoustically cluttered scene remains a difficult task for both machines and hearing-impaired listeners. Normal-hearing listeners accomplish this with relative ease by segregating the into its constituent sound sources, then selecting attending to target source. An assistive listening device that mimics biological mechanisms underlying behavior may provide effective solution those difficulty environments (e.g., cocktail party). Here, we present binaural segregation...
Listening in an acoustically cluttered scene is a difficult task for both machines and hearing-impaired listeners. Normal-hearing listeners can accomplish this with relative ease by grouping certain sounds together (i.e., segregating sound sources), then selecting acoustic target to attend to. An assistive listening device that mimics the biological mechanisms underlying behavior may provide effective solution those difficulty environments (e.g., cocktail-party). Here, we present binaural...
Abstract Attentional modulation of cortical networks is critical for the cognitive flexibility required to process complex scenes. Current theoretical frameworks attention are based almost exclusively on studies in visual cortex, where attentional effects typically modest and excitatory. In contrast, auditory cortex can be large suppressive. A framework explaining lacking, preventing a broader understanding mechanisms underlying attention. Here, we present network model primary (A1). key...