A5068158945- Ginseng Biological Effects and Applications
- Autophagy in Disease and Therapy
- Pharmacological Effects of Natural Compounds
- Genomics, phytochemicals, and oxidative stress
- Polysaccharides and Plant Cell Walls
- Skin Protection and Aging
- melanin and skin pigmentation
- Endoplasmic Reticulum Stress and Disease
- Natural product bioactivities and synthesis
- Food Quality and Safety Studies
- Cancer-related molecular mechanisms research
- Fungal Biology and Applications
- Traditional Chinese Medicine Analysis
- Metabolism, Diabetes, and Cancer
- Biochemical Analysis and Sensing Techniques
- Lichen and fungal ecology
- Cancer therapeutics and mechanisms
- Plant Stress Responses and Tolerance
- Bone Metabolism and Diseases
- Pancreatic function and diabetes
- Bryophyte Studies and Records
- Sirtuins and Resveratrol in Medicine
- Acute Myeloid Leukemia Research
- Hepatocellular Carcinoma Treatment and Prognosis
- Ferroptosis and cancer prognosis
Changchun University of Chinese Medicine
2018-2025
Second Affiliated Hospital of Guangzhou Medical University
2024
Guangdong Medical College
2024
Shandong First Medical University
2021-2024
The Affiliated Hospital to Changchun University of Chinese Medicine
2018-2024
Shandong Provincial QianFoShan Hospital
2021-2024
Ministry of Education of the People's Republic of China
2020-2024
Guangzhou Medical University
2024
Zhengzhou Central Hospital
2022-2023
Northwest University
2022-2023
F. Ginseng (Panax ginseng) is planted in the forest to enhance natural ginseng resources, which have an immense medicinal and economic value. The morphology of cultivated plants becomes similar that wild growing (W. Ginseng) over years. So far, there been no studies highlighting physiological or functional changes its counterparts. In present study, we used proteomic technologies (2DE iTRAQ) coupled mass spectrometry compare W. at various growth stages. Hierarchical cluster analysis based on...
Cancer and diabetes are significant diseases that pose a threat to human health. Their interconnection is complex, particularly when they coexist, often necessitating multiple therapeutic approaches attain remission. Sodium-glucose cotransporter protein two inhibitors (SGLT-2i) emerged as treatment for hyperglycemia, but subsequently exhibited noteworthy extra-glycemic properties, such being registered the of heart failure chronic kidney disease, especially with co-existing albuminuria,...
The present study aimed to compare the relative abundance of proteins and amino acid metabolites explore mechanisms underlying difference between wild cultivated ginseng (Panax Meyer) at level. Two-dimensional polyacrylamide gel electrophoresis isobaric tags for absolute quantitation were used identify differential ginseng. Total acids in compared using an automated analyzer. activities metabolism-related enzymes contents intermediate measured enzyme-linked immunosorbent assay...
Nutrition intervention has become a potential strategy to improve healthspan and prolong lifespan. Ginseng been used for thousands of years developed as functional food provide various protective effects humans. An extract total ginsenosides (TGS), mixture the main active from ginseng, wide biological activities health benefits age-related diseases, including antioxidation improvements in mitochondrial function. However, molecular mechanism TGS prolonging lifespan improving fitness how...
Ginsenosides (GS) have potential value as cosmetic additives for prevention of skin photoaging. However, their protective mechanisms against barrier damage and active monomeric constituents are unknown.GS monomer types relative proportions were identified. A UVB-irradiated BALB/c hairless mouse model was used to assess effects GS components on epidermal thickness transepidermal water loss (TEWL). Skin function, reflected by filaggrin (FLG), involucrin (IVL), claudin-1 (Cldn-1), aquaporin 3...
Aluminum (Al) is considered a pathological factor for various neurological and neurodegenerative diseases, such as Alzheimer's disease (AD) Parkinson's (PD). The neurotoxicity of aluminum can cause oxidative brain damage, trigger apoptosis, ultimately irreversible damage to neurons. DiDang Tang (DDT), classic formula within traditional Chinese medicine promoting blood circulation removing stasis collaterals, widely used the treatment stroke AD. In this study, models stress apoptosis were...
Context The decline in ovarian reserve is a major concern female reproductive health, often associated with oxidative stress and mitochondrial dysfunction. Although ginsenoside Rg1 known to modulate mitophagy, its effectiveness mitigating remains unclear.
China has the second largest birth cohort in world and highest number of deaths due to rotavirus infection. It is also only country with a licensed vaccine. Chinese policy makers now need credible estimates burden disease, decide about vaccine use. From August 2001 through July 2003, prospective hospital-based surveillance for diarrhea among children <5 years age was conducted 6 sentinel hospitals. Rotavirus isolates were characterized determine G P genotypes circulating during study. Of...
A series of reports revealed that autophagy and apoptosis exerted detrimental effects on the pathology cardiac ischemia/reperfusion (I/R) injury. Ginsenoside compound K (CK), a major intestinal metabolite underlying pharmacological actions orally administered ginseng, has protective effect against myocardial I/R However, molecular mechanisms by which CK protects injury remain unclear. In this study, we hypothesized cardioprotective are mediated inhibiting autophagy/apoptosis-related...
Pig brain polypeptides (PBP), active hydrolysate extracted from fresh porcine tissue, has been shown to have neuroprotective effects in both vitro and vivo studies. The present study aimed explore the molecular mechanisms underlying of PBP corticosterone (CORT)-induced rat adrenal pheochromocytoma PC12 cells.Cell viability lactate dehydrogenase (LDH) release were measured cells induced with 200 μM CORT presence or absence various concentrations for 48 h. Intracellular reactive oxygen species...
Muscle atrophy, a side effect from administration of the anti‑inflammatory medication dexamethasone (DEX), is preventable by concomitant major monomeric constituent <em>Panax ginseng</em> C.A. Meyer, 20(S)‑ginsenoside Rg3 (S‑Rg3). Putative S‑Rg3‑associated prevention DEX‑induced muscle atrophy may involve S‑Rg3 mitigation mitochondrial dysfunction. In present study, MTT assays revealed enhanced cell viability following treatment DEX‑injured C2C12 myotubes. Subsequent PCR and western blotting...