A5100398024- Bone Metabolism and Diseases
- Bone health and treatments
- Autophagy in Disease and Therapy
- Signaling Pathways in Disease
- NF-κB Signaling Pathways
- Spinal Cord Injury Research
- Pharmacological Effects of Medicinal Plants
- Computational Drug Discovery Methods
- Endoplasmic Reticulum Stress and Disease
- Pharmacological Effects of Natural Compounds
- Cerebral Palsy and Movement Disorders
- Estrogen and related hormone effects
- Neuroinflammation and Neurodegeneration Mechanisms
- Hereditary Neurological Disorders
- Neurological Disease Mechanisms and Treatments
- Medicinal Plants and Neuroprotection
- Advanced Glycation End Products research
- Stress Responses and Cortisol
- Cancer-related molecular mechanisms research
- Trauma and Emergency Care Studies
- Macrophage Migration Inhibitory Factor
- Mitochondrial Function and Pathology
- Osteomyelitis and Bone Disorders Research
- Bone health and osteoporosis research
- Vitamin D Research Studies
State Key Laboratory of Food Science and Technology
2025
Nanchang University
2025
The Affiliated Hospital to Changchun University of Chinese Medicine
2020-2024
Jilin University
2015-2024
Yantai University
2024
Shanghai Ninth People's Hospital
2024
Shanghai Jiao Tong University
2024
National Clinical Research Center for Digestive Diseases
2024
Stomatology Hospital
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
Calycosin, an isoflavonoid phytoestrogen, isolated from Radix Astragali, was reported to possess anti-tumor, anti-inflammation, and osteogenic properties, but its impact on osteoclast differentiation remains unclear. In this study, we examined the effects of calycosin osteoclastogenesis induced by RANKL. The results showed that significantly inhibited RANKL-induced formation primary bone marrow macrophages (BMMs). Calycosin also dose-dependently suppressed resorption pits mature osteoclasts....
Ulcerative colitis (UC) is a chronic inflammatory bowel disease characterized by recurrent episodes and an inability to achieve complete cure. The spermidine derivative (di-p-coumaroyl-caffeoyl spermidine, SPDD), as key alkaloid, exhibits unique health benefits. However, it has not yet been reported whether SPDD can improve dextran sulfate sodium (DSS)-induced in mice. Herein, we investigated the effects mechanisms of on DSS-induced was successfully purified from rose bee pollen found have...
Osteoporosis is a metabolic bone disease characterized by insufficient osteoblastic function and/or excessive osteoclastic activity. One promising strategy for treating osteoporosis inhibiting osteoclast resorbing Previous studies have revealed that anemonin (ANE), isolated from various types of Chinese natural herbs, has anti-inflammatory and anti-oxidative properties. However, whether ANE regulates osteoclastogenesis unknown. This study aimed to investigate the potential effect on...
Astrocytes act as immune cells that can produce a series of chemokines to attract large numbers leucocytes the lesion site, where they contribute excessive inflammation following spinal cord injury (SCI). However, relevant regulatory mechanism involved in chemokine production by astrocytes has not been fully elucidated. In present study, we examined correlation between C-C motif ligand 5 (CCL5) and high mobility group box-1 protein (HMGB1) T8-T10 contusion model. Our results revealed...
A number of studies demonstrated that some tea extracts exert inhibitory effects on osteoclastogenesis induced by receptor activator nuclear factor κB ligand (RANKL). However, the effect purple tea, a famous in China, remains unclear. In this study, water-based extract (PTE) was found to suppress osteoclast formation, osteoclastic resorption pit area and F-actin ring formation within RANKL-stimulated bone marrow macrophages (BMMs). Furthermore, our results PTE could inhibit expression master...
We have previously reported that the lignin-like compounds, Tatarinan O (TO) and N (TN), extracted from roots of Acorus tatarinowii Schott, inhibit receptor activator nuclear factor-κB ligand (RANKL)-induced osteoclastogenesis. In present study, potential function α-asarone-derived lignins, T (TT) A (TA), to regulate RANKL-induced osteoclastogenesis was investigated, it found only early treatment with TT may RANKL-triggered formation osteoclasts resorption. The results revealed repressed...
Ischemic stroke (IS) is a leading cause of long-term disability and even mortality, threatening people's lives. Yinao Fujian (YNFJ) formula Traditional Chinese Medicine that has been widely used to treat patients with IS. However, the molecular mechanism YNFJ for treatment IS still elusive. Our study aimed explore potential protective effect underlying mechanisms on using network pharmacology approach coupled experimental validation.
Epimedium polysaccharide (EPS) is a bioactive compound derived from the traditional Chinese herb brevicornum. The objective of this study was to investigate protective effects EPS on ulcerative colitis (UC) and elucidate underlying mechanisms involved.
Objectives To explore the effect and probable mechanisms of JLD in treatment type 2 diabetes mellitus (T2DM) - associated cognitive impairment (TDACI).
Abstract Cerebral ischemic stroke is a high-risk disease and imposes heavy burdens on patients in china. Acupuncture has been used for thousands of years to treat motor dysfunction, cognitive disorder language barrier caused by cerebral stroke. Acupoint lines, vertex middle line anterior oblique temple, are always employed However, the mechanism two acupoint lines relieving needs further exploration. In present study, scalp acupuncture treatment alleviated brain damage, cell death induced...