A5015082334- Brucella: diagnosis, epidemiology, treatment
- Bone Metabolism and Diseases
- Galectins and Cancer Biology
- Immune Response and Inflammation
- Influenza Virus Research Studies
- interferon and immune responses
- Toxin Mechanisms and Immunotoxins
- Bone health and treatments
- NF-κB Signaling Pathways
- Ubiquitin and proteasome pathways
- Immune cells in cancer
- Bacteriophages and microbial interactions
- Calpain Protease Function and Regulation
- Bone and Joint Diseases
- Protein Tyrosine Phosphatases
- Monoclonal and Polyclonal Antibodies Research
- Cytokine Signaling Pathways and Interactions
- Burkholderia infections and melioidosis
- Animal Diversity and Health Studies
- Antibiotic Use and Resistance
- Plant-based Medicinal Research
- Escherichia coli research studies
- Signaling Pathways in Disease
- RNA and protein synthesis mechanisms
- Mass Spectrometry Techniques and Applications
Jilin University
2015-2024
Jilin Medical University
2021
Union Hospital
2020
Second Affiliated Hospital of Jilin University
2016-2018
Xinxiang Medical University
2016
Hubei University of Science and Technology
2016
Central South University
2016
Shandong University
2016
University of Oklahoma Health Sciences Center
2008-2013
Fuling Center Hospital of Chongqing
2011
The inositol phosphatase SHIP1 binds to a receptor-adaptor complex on osteoclasts prevent recruitment of PI3K and inhibit receptor signaling.
GTP cyclohydrolase 1 (GCH1) deficiency is critical for endothelial nitric oxide synthase uncoupling in dysfunction. MicroRNAs (miRs) are a class of regulatory RNAs that negatively regulate gene expression. We investigated whether statins prevent dysfunction via miR-dependent GCH1 upregulation.Endothelial function was assessed by measuring acetylcholine-induced vasorelaxation the organ chamber. MiR-133a expression quantitative reverse transcription polymerase chain reaction and fluorescence...
Abstract Berberine, as an alkaloid found in many Chinese herbs, improves vascular functions patients with cardiovascular diseases. We determined the effects of berberine hypertension and ageing, elucidated underlying mechanisms. In isolated aortas, dose‐dependently elicited aortic relaxation. cultured cells, induced relaxation smooth muscle cells ( VSMC s). Overexpression transient receptor potential vanilloid 4 TRPV 4) channel by genetic approaches abolished berberine‐induced reduction...
Calycosin, an isoflavonoid phytoestrogen, isolated from Radix Astragali, was reported to possess anti-tumor, anti-inflammation, and osteogenic properties, but its impact on osteoclast differentiation remains unclear. In this study, we examined the effects of calycosin osteoclastogenesis induced by RANKL. The results showed that significantly inhibited RANKL-induced formation primary bone marrow macrophages (BMMs). Calycosin also dose-dependently suppressed resorption pits mature osteoclasts....
The association of two immune adaptor proteins dampens inflammatory responses to a bacterial product.
Avian influenza A viruses are serious veterinary pathogens that normally circulate among avian populations, causing substantial economic impacts. Some strains of viruses, such as H5N1, H9N2, and recently reported H7N9, have been occasionally found to adapt humans from other species. In order replicate efficiently in the new host, interact with a variety host factors. present study, H7N9 nucleoprotein was transfected into human HEK293T cells, followed by immunoprecipitated analyzed proteomics...
// Fu Wang 1 , Hui Ma Wen-Jing Liang Jing-Jing Yang Xue-Qing Mei-Rong Shan Yuan Chen Min Jia 2 Ya-Ling Yin 3 Xue-Ying Sun 4 Jia-Ning Zhang 5 Qi-Sheng Peng 6 Yu-Guo Li-Ying Liu Li Tao Guo and Shuang-Xi The Key Laboratory of Cardiovascular Remodeling Function Research, Qilu Hospital, Shandong University School Medicine, Jinan, China Department Rehabilitation Jinan Municipal Hospital Traditional Chinese Pharmacology, College Pharmacy, Xinxiang Medical University, Xinxiang, Pharmaceutical...
Aspirin has been used for the secondary prevention and treatment of cardiovascular disease several decades. We investigated roles transcriptional factor activator protein 2α (AP-2α) in beneficial effects aspirin growth vulnerability atherosclerotic plaque.In mice deficient apolipoprotein E (Apoe-/-), (20, 50 mg/kg/day) suppressed progression atherosclerosis aortic roots increased plaque stability carotid plaques induced by collar-placement. In vivo lentivirus-mediated RNA interference AP-2α...
Innate immune activation via Toll-like receptors (TLRs), although critical for host defense against infection, must be regulated to prevent sustained cell that can lead death. Cells repeatedly stimulated with lipopolysaccharide (LPS) develop endotoxin tolerance making the cells hypo-responsive additional TLR stimulation. We show here DOK3 is a negative regulator of signaling by limiting LPS-induced ERK and cytokine responses in macrophages. LPS induces ubiquitin-mediated degradation leading...
Brucella may establish chronic infection by regulating the expression of miRNAs. However, role miRNAs in modulating intracellular growth remains unclear.In this study, we show that Brucella. abortus leads to downregulation miR-125b-5p macrophages. We targets A20, an inhibitor NF-kB activation. Additionally, decreases A20 B. abortus-infected macrophages and activation increased production TNFα. Furthermore, survival is attenuated presence miR-125b-5p.These results uncover a for regulation via...
Pathological angiogenesis is a major cause of vision loss in ischemic and inflammatory retinal diseases. Recent evidence implicates macrophage metalloelastase (MMP-12), macrophage-derived elastinolytic protease inflammation, tissue remodeling angiogenesis. However, little known about the role MMP-12 pathophysiology. The present study aims to explore enzyme's contributions oxygen-induced retinopathy (OIR) using knockout (KO) mice. We find that expression was upregulated OIR, accompanied by...
ABSTRACT Osteoclastogenesis is essential for bone remodeling and normal skeletal maintenance. Receptor activator of NF-κB ligand (RANKL) promotes osteoclast differentiation function but requires costimulation immunoreceptor tyrosine-based activation motif (ITAM)-coupled immunoreceptors. Triggering receptor expressed on myeloid cells-2 (TREM2) coupled to ITAM-adaptor protein DNAX 12kDA (DAP12) provides intracellular calcium signaling during osteoclastogenesis. Previously, we found that...
Osteoporosis is a metabolic bone disease characterized by insufficient osteoblastic function and/or excessive osteoclastic activity. One promising strategy for treating osteoporosis inhibiting osteoclast resorbing Previous studies have revealed that anemonin (ANE), isolated from various types of Chinese natural herbs, has anti-inflammatory and anti-oxidative properties. However, whether ANE regulates osteoclastogenesis unknown. This study aimed to investigate the potential effect on...
The mammalian Sirt1 deacetylase is generally thought to be a nuclear protein, but some pilot studies have suggested that may also involved in orchestrating nucleolar functions. Here, we show stress response ubiquitous cellular reaction can induced by different types of conditions, and an endogenous suppressor response. Using stable isotope labeling amino acids cell culture approach, identified physical interaction between the protein nucleophosmin, this protein-protein appears necessary for...
AMP-activated protein kinase (AMPK) is a serine/threonine that well conserved during evolution. AMPK activation inhibits production of reactive oxygen species (ROS) in cells via suppression NADPH oxidase. However, the role process Brucella infection remains unknown. Our data demonstrate B. abortus induces HeLa time-dependent manner. The known kinases LKB1, CAMKKβ, and TAK1 are not required for by infection. Instead, this dependent on RNase activity inositol-requiring enzyme 1 (IRE1)....