A5100714462- Pain Mechanisms and Treatments
- Neuropeptides and Animal Physiology
- Anesthesia and Pain Management
- Airway Management and Intubation Techniques
- Blood transfusion and management
- Cardiac, Anesthesia and Surgical Outcomes
- Ion channel regulation and function
- Neuroscience and Neuropharmacology Research
- Spinal Cord Injury Research
- Animal Genetics and Reproduction
- Musculoskeletal pain and rehabilitation
- Tracheal and airway disorders
- Nitric Oxide and Endothelin Effects
- Neuroendocrine regulation and behavior
- Receptor Mechanisms and Signaling
- Hereditary Neurological Disorders
- Milk Quality and Mastitis in Dairy Cows
- Bone Metabolism and Diseases
- Pharmacological Receptor Mechanisms and Effects
- Hemodynamic Monitoring and Therapy
- Bone and Joint Diseases
- Pain Management and Placebo Effect
- Digestive system and related health
- Hormonal and reproductive studies
- Bone health and treatments
Peking Union Medical College Hospital
2016-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
1995-2025
Henan Agricultural University
2024-2025
Beth Israel Deaconess Medical Center
2025
Harvard University
2025
Ocean University of China
2024
Beijing Anzhen Hospital
2022
Capital Medical University
2022
Beijing Institute of Water
2022
Ningxia University
2021
Abstract The outbreak of the new Coronavirus disease, COVID-19, has been involved in 77,262 cases China as well 27 other countries February 24, 2020. Because virus is novel to human beings, and there no vaccine yet available, every individual susceptible can become infected. Healthcare workers are at high risk, unfortunately, more than 3,000 healthcare have Anesthesiologists among who an even higher risk becoming infected because their close contact with patients potential exposure...
We examined a pain-related syndrome, which includes mechanical allodynia and autotomy, in rats after ischemic spinal cord injury photochemically induced by laser irradiation for 5–20 min. This procedure results an acute allodynia-like phenomenon lasts several days is possibly related to dysfunction of the GABAB system cord. In some animals this followed chronic symptom with onset varying between 1 week 1.5 months injury, expressed as clearly painful reaction light pressure applied skin area...
1. In the companion paper, we described a state of hypersensitivity that developed in dorsal horn wide dynamic range (WDR) neurons rats after transient spinal cord ischemia. Thus WDR exhibited lower threshold and increased responses to low-intensity mechanical stimuli. The response pattern these suprathreshold electrical stimulation was also changed. Notably, A-fiber input increased. No change thermal found before 2. normal rats, gamma-aminobutyric acid (GABA)B agonist baclofen (0.1 mg/kg...
<ns4:p>The individual and social burdens associated with chronic pain have been escalating globally. Accurate measurement facilitates early diagnosis, disease progression monitoring therapeutic efficacy evaluation, thus is a key for the management of pain. Although “golden standards” are self-reported scales in clinical practice, reliability these subjective methods could be easily affected by patients’ physiological psychological status, as well assessors’ predispositions. Therefore,...
Injury to the central or peripheral nervous system is often associated with persistent pain. After ischemic injury spinal cord, rats develop severe mechanical allodynia-like symptoms, expressed as a pain-like response innocuous stimuli. In its short-lasting phase allodynia can be relieved gamma-aminobutyric acid (GABA)-B receptor agonist baclofen, which also reverses hyperexcitability of dorsal horn interneurons Furthermore, there reduction in GABA immunoreactivity allodynic rats. Clinical...
The interaction between morphine and three antagonists of the N-methyl-D-aspartate (NMDA) receptor. MK-801 (non-competitive channel blocker), dextromethorphan (clinically available non-competitive antagonist) CGS19755 (competitive receptor antagonist), was examined in rats with hot plate test. NMDA were administered intraperitoneally none them caused antinociception at doses that did not produce motor deficits (0.1 mg kg-1 MK-801, 30 5 CGS19755). However, pretreatment these min prior to...
The spinal N-methyl-d-aspartate (NMDA) receptor, and particularly its NR2B subunit, plays a pivotal role in neuropathic pain. However, the of peripheral NMDA receptor pain is less well understood. We first treated cultured human keratinocytes, HaCaT cells with or NR2B-specific antagonist, ifenprodil evaluated level total phosphorylated at 24 h using Western blot. Next, chronic post-ischemia (CPIP) model, we administered subcutaneously into hind paws male rats. Nociceptive behaviors were...
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has spread worldwide. During the ongoing COVID-19 epidemic, most hospitals have postponed elective surgeries. However, some emergency surgeries, especially for trauma patients, are inevitable. For patients with suspected or confirmed COVID-19, a standard protocol addressing preoperative preparation, intraoperative management, and postoperative surveillance should be implemented to...
Background/Objectives: Patients undergoing neoadjuvant therapy have ample time to engage in exercise prehabilitation. This study aimed describe the current status, facilitators, and barriers of prehabilitation among this population. Methods: sequential explanatory mixed-methods evaluation was conducted at a general tertiary hospital Beijing. It included quantitative survey patients who received before cancer surgery qualitative semi-structured interviews with both physicians. Thematic...
Abstract Background Sore throat is a remarkable complication after thyroid surgery with endotracheal tube (ETT). Many studies revealed that laryngeal mask airway (LMA) might reduce the incidence and severity of postoperative sore throat. However, little known about use flexible reinforced LMA (FLMA) in surgery. The purpose this study was to explore potential benefits FLMA compared ETT on Methods In prospective, single-blinded, randomized, controlled trial, ninety-six patients aged 20–80...
Reportedly, the number of κ-casein (κ-CN) B alleles increases proportion κ-CN to total protein and content. This phenomenon is caused by single-nucleotide polymorphisms (SNPs) in promoter region CSN3, which encodes variant. Therefore, a series 5'-deleted plasmids were constructed define core CSN3. The activity was analyzed comparing luciferase among recombinant vectors with truncated promoters. No mutation occurred (5'-ctatcgtcagatctttcctttctgtcatcttcctattggtg-3') CSN3 40 cows. A 2092 bp...
Abstract Background Chronic pain of neuropathic nature after spinal cord injury ( SCI ) is common and its underlying mechanisms are poorly understood. Genes, as well sex, have been implicated, but not thoroughly investigated in experimental genetic models for complex traits. We previously found that inbred D ark‐ A gouti DA rats develop more severe pain‐like behaviour than a major histocompatibility complex‐congenic Piebald Virol Glaxo PVG )‐ RT 1 av1 strain model photochemically induced ....