A5003323238- Bone Metabolism and Diseases
- Bone health and treatments
- NF-κB Signaling Pathways
- MicroRNA in disease regulation
- Thyroid Disorders and Treatments
- RNA modifications and cancer
- Diet and metabolism studies
- Cancer-related molecular mechanisms research
- Macrophage Migration Inhibitory Factor
- Liver Disease Diagnosis and Treatment
- Pregnancy and preeclampsia studies
- Adipokines, Inflammation, and Metabolic Diseases
- Endoplasmic Reticulum Stress and Disease
- Signaling Pathways in Disease
- Bone and Joint Diseases
- Immune cells in cancer
- Bone health and osteoporosis research
- Nanoparticles: synthesis and applications
- Inflammatory mediators and NSAID effects
- Thyroid Cancer Diagnosis and Treatment
- Pharmacological Effects of Medicinal Plants
- Alkaline Phosphatase Research Studies
- Liver physiology and pathology
- Infant Nutrition and Health
- Genetics, Aging, and Longevity in Model Organisms
Jiangxi University of Traditional Chinese Medicine
2025
Wuhu No 1 People's Hospital
2023-2024
Anhui University of Science and Technology
2024
Tongji University
2017-2022
University of Chinese Academy of Sciences
2020
Institute of Biophysics
2020
Chinese Academy of Sciences
2020
Jilin University
2015-2017
Beihua University
2017
Peking University
2011
Calycosin, an isoflavonoid phytoestrogen, isolated from Radix Astragali, was reported to possess anti-tumor, anti-inflammation, and osteogenic properties, but its impact on osteoclast differentiation remains unclear. In this study, we examined the effects of calycosin osteoclastogenesis induced by RANKL. The results showed that significantly inhibited RANKL-induced formation primary bone marrow macrophages (BMMs). Calycosin also dose-dependently suppressed resorption pits mature osteoclasts....
Polygonum multiflorum Thunb (PMT), as a traditional Chinese herbal medicine, has been widely used in the prevention and treatment of aging-related diseases, including Alzheimer's disease, Parkinson's hyperlipidemia, atherosclerosis inflammation. However, effect PMT on lifespan its molecular mechanisms are still unclear. Here we found that 60% ethanol refined fraction (PMT-E) at 50 μg mL-1, which contained two main bioactive compounds, 2,3,5,4'-tetrahydroxystilbene-2-O-β-D-glucoside (TSG)...
Aims: This study aims to explore the mutual mechanisms and distinct pathogenic factors between fasting blood glucose (FBG) abnormalities thyroid dysfunction (TD) in major depressive disorder (MDD) patients of different onset ages. Methods: One thousand seven hundred eighteen first-episode drug-naïve (FEDN) MDD were selected. Hamilton Depression Rating Scale (HAMD), Anxiety (HAMA), Positive Negative Syndrome (PANSS) positive subscale, Clinical Global Impression (CGI), FBG, thyroid-stimulating...
Osteoporosis is a metabolic bone disease characterized by insufficient osteoblastic function and/or excessive osteoclastic activity. One promising strategy for treating osteoporosis inhibiting osteoclast resorbing Previous studies have revealed that anemonin (ANE), isolated from various types of Chinese natural herbs, has anti-inflammatory and anti-oxidative properties. However, whether ANE regulates osteoclastogenesis unknown. This study aimed to investigate the potential effect on...
Abstract Previous studies have found that miR-335 is highly expressed in type II diabetes mellitus (T2DM) models and related to insulin secretion, but there are few on the regulatory effects of miR-335-3p resistance macrophage polarization T2DM patients. This study aims explore Blood glucose (insulin tolerance tests, tests) body weight model were measured; macrophages from adipose tissue isolated cultured, number was detected by F4/80 immunofluorescence assay; Real-time quantitative...
Sec-O-glucosylhamaudol (SOG), an active flavonoid compound derived from the root of Saposhnikovia divaricata (Turcz. ex Ledeb.) Schischk., exhibits analgesic, anti-inflammatory, and high 5-lipoxygenase (5-LO) inhibitory effects. However, its effect on osteoclastogenesis was unclear. We demonstrated that SOG markedly attenuated RANKL-induced osteoclast formation, F-actin ring mineral resorption by reducing induction key transcription factors NFATc1, c-Fos, their target genes such as TRAP,...
Preterm labor, one of the common pathological phenomena during pregnancy, necessitates prompt and accurate detection to safeguard health both pregnant women newborns. This study focused on placental alkaline phosphatase, a pregnancy-specific enzyme, its potential role in identifying preterm labor. aimed investigate relationship between maturity, nutritional status newborns, utility evaluating A total 85 with singleton pregnancy more than 15 weeks gestation admitted our hospital from March...
Abstract Background Osteoclast excessive activation was closely related to bone diseases such as osteoporosis and rheumatoid arthritis. Sec-O-glucosylhamaudol (SOG), an active flavonoid compound derived from the root of divaricate Saposhnikovia , reported exhibit analgesic, anti-inflammatory high 5-lipoxygenase (5-LO) inhibitory effects. However, its effect on osteoclastogenesis resorption remained unclear. Methods formation, pit area formation F-actin ring were examined by TRAP staining,...