A5100332595- Immunotherapy and Immune Responses
- T-cell and B-cell Immunology
- Advanced Radiotherapy Techniques
- Immune Cell Function and Interaction
- Radiomics and Machine Learning in Medical Imaging
- Cancer Immunotherapy and Biomarkers
- Medical Imaging Techniques and Applications
- Chemokine receptors and signaling
- Endometrial and Cervical Cancer Treatments
- CAR-T cell therapy research
- Lung Cancer Diagnosis and Treatment
- Immune cells in cancer
- Prostate Cancer Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- Low-power high-performance VLSI design
- Adipokines, Inflammation, and Metabolic Diseases
- Nuclear Physics and Applications
- Renal cell carcinoma treatment
- Magnetic and transport properties of perovskites and related materials
- Nanoplatforms for cancer theranostics
- Analog and Mixed-Signal Circuit Design
- Ultrasound and Hyperthermia Applications
- Cervical Cancer and HPV Research
- Nanowire Synthesis and Applications
- Biological and pharmacological studies of plants
Second Hospital of Shandong University
2023-2025
Fudan University
2022-2024
Wuhu No 1 People's Hospital
2024
Anhui University of Science and Technology
2024
Shandong First Medical University
2023
Shanghai Sixth People's Hospital
2022-2023
Shanghai Jiao Tong University
2019-2023
First Affiliated Hospital of Zhengzhou University
2023
Chonnam National University
2023
Huadong Hospital
2022
Fast and accurate outlining of the organs at risk (OARs) high-risk clinical tumor volume (HRCTV) is especially important in high-dose-rate brachytherapy due to highly time-intensive online treatment planning process high dose gradient around HRCTV. This study aims apply a self-configured ensemble method for fast reproducible auto-segmentation OARs HRCTVs gynecological cancer.
Background. Creating a clinically acceptable plan in the time-sensitive clinic workflow of brachytherapy is challenging. Deep learning-based dose prediction techniques have been reported as promising solutions with high efficiency and accuracy. However, current studies mainly target EBRT which are inappropriate for brachytherapy, model designed specifically has not yet well-established.Purpose. To predict distribution using novel Squeeze Excitation Attention Net (SE_AN) model.Method. We...
The primary aim of this study was to evaluate the safety a novel dendritic cell (DC) vaccine pulsed with survivin and MUC1, silenced suppressor cytokine signaling 1 (SOCS1), immune stimulated flagellin for patients stage I IIIA non-small lung cancer (NSCLC) in phase open-label, uncontrolled, dose-escalation trial. Moreover, we potential efficacy modified DC as secondary aim.The were treated at × 106, 107and maximum dose 8 107 day 7, 14, 21 after characterization phenotype by flow cytometry....
Abstract Background Bladder cancer is a common and highly heterogeneous malignant tumor with relatively poor prognosis. Thus, personalized treatment strategies for bladder are essential improving patient outcomes. Materials methods We developed an efficient 3-dimensional in vitro organoid culture system organoids (BCOs), which maintains the homology original tumors heterogeneity between different individuals. In addition, we constructed chimeric antigen receptor (CAR)-T cells targeting B7H3...
Various challenges, including tumor heterogeneity and inadequate T cell infiltration, impede the progress of chimeric antigen receptor (CAR-T) therapy for glioblastoma (GBM). To address these obstacles, a multiple step strategy is designed. Initially, literature review bioinformatics analysis to screen set antigens that are heterogeneously expressed in GBM, which designated as target-bank, leveraged. Then, according multiplex immunohistochemistry results each patient's sample, personalized...
Abstract Previous studies have found that miR-335 is highly expressed in type II diabetes mellitus (T2DM) models and related to insulin secretion, but there are few on the regulatory effects of miR-335-3p resistance macrophage polarization T2DM patients. This study aims explore Blood glucose (insulin tolerance tests, tests) body weight model were measured; macrophages from adipose tissue isolated cultured, number was detected by F4/80 immunofluorescence assay; Real-time quantitative...
Although the knowledge-based dose-volume histogram (DVH) prediction has been largely researched and applied in External Beam Radiation Therapy, it is still less investigated domain of brachytherapy. The purpose this study to develop a reliable DVH method for high-dose-rate brachytherapy plans.A workflow combining kernel density estimation (KDE), k-nearest neighbor (kNN), principal component analysis (PCA) was proposed. PCA kNN were first employed together select similar patients based on...
Objective To study the polymorphisms of human leukocyte antigen (HLA)-A, B and DRB1 genes haplotypes at high-resolution level in Northern Chinese Han population. Methods 631 randomly selected individuals were genotyped by polymerase chain reaction-sequence based typing (PCR-SBT) method for their HLA-A, genes, then frequencies alleles estimated maximum-likehood estimation method. Results Thirty HLA-A observed five common with higher than 0.05 which included A * 1101, 2402, A* 0207, 0201 3303...
Dendritic cells (DCs) are a unique class of immune vital to the system, functioning as antigen-presenting that play key role in launching both cellular and humoral responses. They crucial preventing infectious diseases regulating tumor growth. DCs can be categorized based on various criteria such phenotype, function, tissue location, resulting several subgroups. Generally, divided into two primary groups: plasmacytoid (pDCs) conventional (cDCs), which further classified Type I classical...
Our previous study showed that the chemokine regulated upon activation normal T-cell expressed and secreted (RANTES) originating from mouse epididymis bound to midpiece of luminal spermatozoa. The present was undertaken investigate association between RANTES epididymal spermatozoa determine whether is mediated by receptors CCR1, CCR3 or CCR5. use reverse transcription polymerase chain reaction (RT-PCR), immunohistochemical staining immunofluorescent demonstrated apical narrow cells ducts...
Purpose:This study aims to develop a deep learning (DL)-based (Mask R-CNN) method predict the internal target volume (ITV) in cone beam computed tomography (CBCT) images for lung stereotactic body radiotherapy (SBRT) patients and evaluate prediction accuracy of model using 4DCT as ground truth. Methods Materials: This enrolled 78 phantom cases 156 patient who received SBRT treatment. We used novel DL identify delineate tumor ITV CBCT images. The results DL-based were compared quantitatively...
The solid-phase reaction experiment and principle were introduced. 1000# SiO 2 micromist CaO powder used polishing sapphire, with pressure 7.5kPa，polishing speed 60r/min 40r/min. process of was separated every 120 minutes. surface appearance roughness will be survey in each part. Non-surface-scratch achieved after 600min polishing. (Ra) decreased from 395nm to 7nm. Rmax 2.98μm 0.05μm. Rt 3.34μm Through the analysis experimental data XRD, kyanite phase map diffraction pattern fitting degree....